Actively Recruiting
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)
Led by Fondazione IRCCS Policlinico San Matteo di Pavia · Updated on 2026-04-16
760
Participants Needed
4
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The investigators plan to establish a dedicated network of Italian Hematologic Departments interconnected with the Amyloidosis Research and Treatment Center in Pavia to: 1. Implement a biomarker-based screening strategy to promote early diagnosis of AL amyloidosis among at-risk patients, including patients with monoclonal gammopathy of undetermined significance, MGUS, and altered free light chain ratio (aFLCR), and patients with smoldering multiple myeloma (SMM) 2. Expedite and facilitate patients' referral and their enrollment in ongoing pre-clinical/clinical studies, also to reflect a broader spectrum of the real-world population of patients with AL amyloidosis in Italy; 3. Investigate the clinical utility of novel diagnostic technologies, including light chain sequencing and N-glycosylation analysis
CONDITIONS
Official Title
Promoting Diagnosis and Management of AL in Italy (ProDigALIty)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of MGUS with altered free light chain ratio or smoldering multiple myeloma
- Treatment-na�efve patients
- Age 18 years or older
- Ability to understand and willingness to sign informed consent
- Planned follow-up at participating center
- Diagnosis of systemic AL amyloidosis
You will not qualify if you...
- Diagnosis of symptomatic monoclonal gammopathies
- Previous treatment for monoclonal gammopathies
- Non-AL amyloidosis
- Previous treatment for AL amyloidosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Azienda Ospedaliera Policlinico Consorziale
Bari, Italy
Actively Recruiting
2
Azienda Ospedaliero Universitaria Policlinico G.Rodolico - San Marco
Catania, Italy
Actively Recruiting
3
Fondazione Irccs Policlinico San Matteo
Pavia, Italy
Actively Recruiting
4
EMATOLOGIA - Città della Scienza e Salute - Torino
Torino, Italy
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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