Actively Recruiting

Age: 18Years - 99Years
All Genders
ID07253974

Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study TARGET: Health Virtual Twins for the Personalised Management of Stroke Related to Atrial Fibrillation

Led by Parc de Salut Mar · Updated on 2025-12-15

213

Participants Needed

1

Research Sites

55 weeks

Total Duration

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AI-Summary

What this Trial Is About

This research aims to understand how the intensity of rehabilitation programs affects recovery in adult patients who have had an ischemic stroke and require inpatient rehabilitation. It focuses on whether patients with atrial fibrillation-related stroke (AFRS) have different rehabilitation needs and outcomes compared to those without AFRS. The study is observational and does not interfere with patients' usual care, aiming to improve knowledge about recovery following different standard rehabilitation programs. Participants will receive rehabilitation therapy after discharge from the stroke unit at one of two centers. One center provides a high-intensity program with 3 to 5 therapy sessions daily, including physiotherapy, occupational therapy, and speech-language therapy. The other offers a moderate-intensity program with about one session daily. Patients are assigned to these programs based on factors like age, prior functional level, stroke severity, and cognitive status. Participants will be assessed at multiple points: at the start of inpatient rehabilitation, at discharge, and at 1, 3, and 6 months after the stroke. Assessments include the Barthel Index to measure functional independence, as well as various tests for mobility, balance, cognition, mood, and swallowing. The study collects detailed data on recovery progression while patients continue their usual care. The total follow-up period extends to six months post-stroke.

CONDITIONS

Brief Title

Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study

Who Can Participate

Age: 18Years - 99Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older
  • First-ever intracerebral ischemic stroke
Not Eligible

You will not qualify if you...

  • Intracranial hemorrhage or symptomatic hemorrhagic transformation
  • New infarcts after the initial stroke
  • Other neurological or psychiatric conditions

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Monitoring

Duration - Up to 6 months after the acute stroke event

Participants who have experienced a stroke are observed after discharge from the Stroke Unit to document recovery trajectories and rehabilitation needs based on stroke type and severity.

Baseline assessment at admission to rehabilitation and follow-up visits at 1 month, 3 months, and 6 months

Rehabilitation

Duration - Varies depending on individual rehabilitation needs during inpatient stay

Participants undergo inpatient rehabilitation programs of either high or moderate intensity based on individual clinical factors, including physiotherapy, occupational therapy, speech therapy, and other therapies to support functional recovery.

Daily therapy sessions (1 to 5 sessions per day depending on rehabilitation program intensity)

Trial Site Locations

Total: 1 location

1

Rehabilitation Research Group, IMIM

Barcelona, Spain, 08006

Actively Recruiting

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Research Team

A

Anna Guillen-Sola, MD, PhD

E

Ester Marco Navarro, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

TARGET: A Major European Project Aiming to Advance the Personalised Management of Atrial Fibrillation-Related Stroke via the Development of Health Virtual Twins Technology and Artificial Intelligence.

Sandra Ortega-Martorell, Ivan Olier, Mattias Ohlsson...

https://pubmed.ncbi.nlm.nih.gov/39401519

Poststroke rehabilitation: outcomes and reimbursement of inpatient rehabilitation facilities and subacute rehabilitation programs.

Anne Deutsch, Carl V Granger, Allen W Heinemann...

https://pubmed.ncbi.nlm.nih.gov/16627797

Comprehensive overview of nursing and interdisciplinary rehabilitation care of the stroke patient: a scientific statement from the American Heart Association.

Elaine L Miller, Laura Murray, Lorie Richards...

https://pubmed.ncbi.nlm.nih.gov/20813995