Observing Brain Blood Flow Using Transcranial Doppler Ultrasound Before and After Polyetheretherketone Cranioplasty in Adults

What this Trial Is About

Researchers are investigating the use of polyetheretherketone PEEK material in cranioplasty surgery to assess cerebral blood flow using transcranial doppler ultrasound. This prospective observational study focuses on patients with cranial defects treated with PEEK cranioplasty. It aims to evaluate brain tissue and ventricular morphology through ultrasound imaging performed before and after surgery to better understand cerebral hemodynamic changes. Participants undergo transcranial doppler ultrasound examinations preoperatively and again 10 days postoperatively. The study collects data on bilateral hemodynamic parameters from arteries including the middle cerebral artery MCA, terminal internal carotid artery TICA, anterior communicating artery ACA, and posterior cerebral artery PCA. Parameters such as peak systolic velocity Vs, end-diastolic velocity Vd, mean velocity Vm, pulsatility index PI, and resistive index RI are recorded from the temporal window. During the study, participants will have ultrasound assessments to monitor cerebral blood flow changes related to the cranioplasty. The primary outcome measure is the transcranial doppler ultrasound parameters before and after the surgery, tracked over a 6-month period. This observational approach helps understand the effects of PEEK cranioplasty on brain hemodynamics without altering standard patient care.

A Prospective Observational Study of Transcranial Doppler Ultrasound in the Assessment of Cerebral Blood Flow After Polyetheretherketone Cranioplasty