Actively Recruiting
Prostate Metabolism, Cancer Risk and Gut Microbiota
Led by Turku University Hospital · Updated on 2023-11-03
300
Participants Needed
2
Research Sites
139 weeks
Total Duration
On this page
Sponsors
T
Turku University Hospital
Lead Sponsor
U
University of Turku
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the relationship between gut microbiota—the community of microbes in the gastrointestinal tract—and prostate cancer, which is the most common cancer among men in Finland and many western countries. This study aims to confirm earlier findings that suggest differences in gut microbiota may influence prostate cancer risk and to explore metabolic features in the gut, blood, and prostate tissue in men with varied gut bacteria profiles. Participants are grouped into multiple cohorts based on their prostate condition: those with suspicion of prostate cancer undergoing diagnostic tests including MRI and biopsies; men with clinically significant prostate cancer planned for radical prostatectomy; men with benign prostate hyperplasia scheduled for transurethral resection of the prostate (TURP); and men with bladder cancer planned for cystoprostatectomy. Alongside routine clinical procedures, blood, urine, and tissue samples will be collected for study analyses. During the study, participants undergo prostate MRI scans, laboratory visits for blood and urine collection, prostate biopsies if indicated, and surgical procedures when applicable. Researchers will analyze gut microbiota signatures immediately before biopsies and study metabolic markers as secondary measures. The study involves follow-up assessments and tissue sample analyses to better understand connections between gut microbiota and prostate disease. Participation requires compliance with study procedures over the duration of the study.
CONDITIONS
Brief Title
Prostate Metabolism, Cancer Risk and Gut Microbiota
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed and dated informed consent form.
- Ability and willingness to comply with all study procedures and be available for the study duration.
You will not qualify if you...
- Inability to comply with study procedures or unwillingness to participate in the study.
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 4 weeks
Participants undergo prostate cancer diagnostics including MRI scans, laboratory tests, and prostate biopsies as part of routine outpatient care.
1 MRI and laboratory visit and 1 biopsy visit
Duration - Based on clinical treatment schedule
Participants diagnosed with prostate conditions may undergo surgery such as radical prostatectomy, TURP, or cystoprostatectomy, with collection of blood, urine, and tissue samples during the procedures.
1 surgical visit (in-person)
Duration - Ongoing after diagnostic and treatment procedures
Participants are observed over time to study gut microbiota and metabolic characteristics in relation to prostate health.
Additional follow-up visits depending on cohort assignment
Trial Site Locations
Total: 2 locations
1
University of Turku
Turku, Finland, 20100
Actively Recruiting
2
Turku University Hospital
Turku, Finland
Actively Recruiting
Research Team
P
Peter J. Bostrom, MD, PhD
T
Tarja Lamminen, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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