What is this study trying to find out about spastic paraplegia?

This study aims to understand the clinical features and natural progression of spastic paraplegia and related disorders. Researchers will assess genetic and epigenetic factors to improve clinical management. The lead sponsor is Wan-Jin Chen. Participants will help advance knowledge about this condition over time.

Who may be eligible for this spastic paraplegia clinical trial?

Adults diagnosed with spastic paraplegia or unrelated healthy controls of any gender may be eligible. Participants must be willing to take part and not have serious conditions interfering with adherence. Please review eligibility criteria for more details.

Is there any cost to participate in this spastic paraplegia clinical trial?

Study-related care, including all trial visits and assessments, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly for travel and related costs.

Actively Recruiting

All Genders

Healthy Volunteers

ID04006418

A Prospective Cohort Study to Understand Hereditary Spastic Paraplegia and Related Disorders

Led by Wan-Jin Chen · Updated on 2022-01-19

500

Participants Needed

Research Sites

521 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are conducting a prospective multicenter natural history study to understand the clinical spectrum and progression of Hereditary Spastic Paraplegias HSP and related disorders. This study aims to evaluate the clinical, genetic, and epigenetic characteristics of patients with spastic paraplegia to improve clinical management. The focus is on gathering comprehensive data to better characterize this condition over time. This observational study does not involve specific drug treatments but follows patients and healthy controls to monitor their condition. Participants include those clinically diagnosed with spastic paraplegia and unrelated healthy individuals. The study collects detailed information to assess disease features and progression. Participants will undergo evaluations using tools like the Spastic Paraplegia Rating Scale SPRS every six months to track their condition. The study will monitor clinical signs and gather genetic and epigenetic data. Participation involves regular assessments to capture the natural course of the disease, aiding researchers in understanding and managing spastic paraplegia better.

CONDITIONS

Brief Title

A Registered Cohort Study on Spastic Paraplegia

Who Can Participate

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Patients with the clinical diagnosis of spastic paraplegia
Clinical diagnosis of patients with spastic paraplegia
Unrelated healthy controls

You will not qualify if you...

Decline to participate
Serious neurological, psychological, or medical conditions that interfere with participation or adherence to the research protocol

Research Team

Yi Lin, MD,PhD

Wan-Jin Chen, MD,PhD

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