Spinal cord cross sign: a potential marker for hereditary spastic paraplegia type 5.
Fan Zhang, Jianping Hu, Zebin Xiao...
https://pubmed.ncbi.nlm.nih.gov/39853345Actively Recruiting
All Genders
Healthy Volunteers
ID04006418
A Registered Cohort Study on Spastic Paraplegia
Led by Wan-Jin Chen · Updated on 2022-01-19
500
Participants Needed
1
Research Sites
521 weeks
Total Duration
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AI-Summary
What this Trial Is About
Researchers are conducting a prospective multicenter natural history study to understand the clinical spectrum and progression of Hereditary Spastic Paraplegias (HSP) and related disorders. This study aims to evaluate the clinical, genetic, and epigenetic characteristics of patients with spastic paraplegia to improve clinical management. The focus is on gathering comprehensive data to better characterize this condition over time. This observational study does not involve specific drug treatments but follows patients and healthy controls to monitor their condition. Participants include those clinically diagnosed with spastic paraplegia and unrelated healthy individuals. The study collects detailed information to assess disease features and progression. Participants will undergo evaluations using tools like the Spastic Paraplegia Rating Scale (SPRS) every six months to track their condition. The study will monitor clinical signs and gather genetic and epigenetic data. Participation involves regular assessments to capture the natural course of the disease, aiding researchers in understanding and managing spastic paraplegia better.
CONDITIONS
Brief Title
A Registered Cohort Study on Spastic Paraplegia
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Patients with the clinical diagnosis of spastic paraplegia
- Clinical diagnosis of patients with spastic paraplegia
- Unrelated healthy controls
You will not qualify if you...
- Decline to participate
- Serious neurological, psychological, or medical conditions that interfere with participation or adherence to the research protocol
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Monitoring
Duration - 6 months
Participants with spastic paraplegia and healthy controls are observed and assessed over time to monitor their condition.
Assessments at baseline and 6 months
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital Fujian Medical University
Fuzhou, China
Actively Recruiting
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Research Team
Y
Yi Lin, MD,PhD
W
Wan-Jin Chen, MD,PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Relationship between brain white matter damage and grey matter atrophy in hereditary spastic paraplegia types 4 and 5.
Yuqing Tu, Ying Liu, Shuping Fan...
https://pubmed.ncbi.nlm.nih.gov/38651515Chinese patients with hereditary spastic paraplegias (HSPs): a protocol for a hospital-based cohort study.
Yu-Sen Qiu, Yi-Heng Zeng, Ru-Ying Yuan...
https://pubmed.ncbi.nlm.nih.gov/35017251Potential markers for sample size estimations in hereditary spastic paraplegia type 5.
Qianqian Lin, Ying Liu, Zhixian Ye...
https://pubmed.ncbi.nlm.nih.gov/34538260