Actively Recruiting
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
Led by Novo Nordisk A/S · Updated on 2026-03-11
200
Participants Needed
92
Research Sites
133 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure. Participants will either get CDR132L or placebo (a medicine which has no effect on the body), which treatment the participants get is decided by chance. The study will last for about 60 weeks.
CONDITIONS
Official Title
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 40 and 84 years at the time of consent
- Diagnosed symptomatic heart failure for at least 180 days with weekly oral diuretic use
- New York Heart Association class II-III at screening
- Clinically stable and on unchanged optimized heart failure therapy for at least 45 days before randomization
- Left ventricular ejection fraction less than 50% by echocardiography
- Left ventricular hypertrophy or dilatation confirmed by echocardiography using specified measurements
- Body mass index between 18.5 and 40 kg/m² and body weight less than or equal to 140 kg
- N-terminal pro B-type natriuretic peptide (NT-proBNP) level at least 300 pg/mL, or at least 600 pg/mL if atrial fibrillation/flutter is present
You will not qualify if you...
- Estimated glomerular filtration rate less than 30 mL/min/1.73 m² at screening
- Acute kidney failure or injury within 90 days before randomization
- Myocardial infarction, unstable angina, or heart failure hospitalization within 30 days before screening
- Use of intravenous heart failure medications within 45 days before randomization
- Planned heart procedures such as coronary revascularization or device implantation at randomization
- Stroke or transient ischemic attack within 12 months before randomization
- Conditions affecting the blood-brain barrier like multiple sclerosis
- Severe liver disease or high liver enzyme levels above 2.5 times normal
- Known or suspected genetic causes of increased heart muscle mass
- Suspected or diagnosed cardiac amyloidosis or sarcoidosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 92 locations
1
Concord Repatriation General Hospital - Cardiology Department
Concord, New South Wales, Australia, 2139
Actively Recruiting
2
The Prince Charles Hospital
Brisbane, Queensland, Australia, 4032
Not Yet Recruiting
3
Royal Adelaide Hospital - Cardiology Department
Adelaide, South Australia, Australia, 5000
Actively Recruiting
4
Flinders Medical Centre
Bedford Park, South Australia, Australia, 5042
Actively Recruiting
5
Royal Hobart Hospital
Hobart, Tasmania, Australia, 7000
Actively Recruiting
6
Victorian Heart Hospital
Clayton, Victoria, Australia, 3168
Actively Recruiting
7
Fiona Stanley Hospital - Cardiology
Murdoch, Western Australia, Australia, 6150
Actively Recruiting
8
Fakultní nemocnice u sv. Anny v Brně
Brno, Czechia, 602 00
Completed
9
Nemocnice České Budějovice a.s.
České Budějovice, Czechia, 370 01
Actively Recruiting
10
Fakultní Nemocnice Ostrava
Ostrava-Poruba, Czechia, 708 52
Actively Recruiting
11
Vseobecna fakultni nemocnice v Praze
Prague, Czechia, 128 08
Actively Recruiting
12
Pratia Prague, s.r.o
Prague, Czechia, 130 00
Not Yet Recruiting
13
IKEM
Prague, Czechia, 140 21
Actively Recruiting
14
Sana Kliniken Berlin-Brandenburg GmbH - Lichtenberg
Berlin, Germany, 10365
Completed
15
Charité - Campus Benjamin Franklin - Klinik für Kardiologie
Berlin, Germany, 12203
Not Yet Recruiting
16
Charité - Campus Virchow-Klinikum - Kardiologie, Angiologie und Intensivmedizin (CRU)
Berlin, Germany, 13353
Actively Recruiting
17
Uniklinik TU Dresden - Herzzentrum Dresden GmbH
Dresden, Germany, 01307
Actively Recruiting
18
Universitaetsklinikum Essen - Klinik für Kardiologie und Angiologie
Essen, Germany, 45147
Not Yet Recruiting
19
Universitätsklinikum Frankfurt aM - Kardiologie
Frankfurt am Main, Germany, 60596
Actively Recruiting
20
Universitätsklinikum Halle - Innere Medizin III
Halle, Germany, 06120
Actively Recruiting
21
Medizinische Hochschule Hannover - Kardiologie und Angiologie
Hanover, Germany, 30625
Actively Recruiting
22
UniklinikHeidelberg - Innere Med. III - Kardiologie, Angiologie, Pneumologie
Heidelberg, Germany, 69120
Actively Recruiting
23
Uniklinik Schleswig-Holstein - Med. Klinik III Kardiologie und Internist. Intensivmedizin
Kiel, Germany, 24105
Actively Recruiting
24
Rhythm Heart Institute
Vadodara, Gujarat, India, 390022
Actively Recruiting
25
Lisie Hospital
Kochi, Kerala, India, 682018
Actively Recruiting
26
Seth GS Medical College & KEM Hospital
Mumbai, Maharashtra, India, 400012
Actively Recruiting
27
Arneja Heart & Multispeciality Hospital
Nagpur, Maharashtra, India, 440010
Actively Recruiting
28
Arneja Heart & Multispeciality Hospital
Nagpur, Maharashtra, India, 440010
Not Yet Recruiting
29
G B Pant Institute of Postgraduate Medical Education and Research
New Delhi, National Capital Territory of Delhi, India, 110002
Actively Recruiting
30
VMMC & Safdarjung Hospital
New Dehli, New Delhi, India, 110029
Actively Recruiting
31
Dayanand Medical College & Hospital
Ludhiana, Punjab, India, 141001
Actively Recruiting
32
Shri Mahant Indiresh Hospital
Dehradun, Uttarakhand, India, 248001
Actively Recruiting
33
Sir Ganga Ram Hospital-Cardiology
New Delhi, India, 110060
Actively Recruiting
34
Sir Ganga Ram Hospital-Cardiology
New Delhi, India, 110060
Not Yet Recruiting
35
NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine
Bunkyo-ku, Tokyo, Japan, 113-8603
Actively Recruiting
36
JA Shizuoka Kohseiren Enshu Hospital_ Cardiology
Hamamatsu-shi, Shizuoka, Japan, 430-0929
Not Yet Recruiting
37
Hyogo Prefectural HarimaHimeji General Medical Center_Cardiology
Himeji-shi, Hyogo, Japan, 670-8560
Actively Recruiting
38
National Hospital Organization Mito Medical Center_Cardiovascular medicine
Ibaraki, Japan, 311-3193
Actively Recruiting
39
Yokohama City University Medical Center_Cardiovascular Center
Kanagawa, Japan, 232-0024
Actively Recruiting
40
Yokohama City University Medical Center_Cardiovascular Center
Kanagawa, Japan, 232-0024
Not Yet Recruiting
41
Kagawa University Hospital_Cardiology
Kita-gun, Kagawa, Japan, 761-0793
Completed
42
Kobe City Medical Center General Hospital_Cardiology
Kobe-shi, Hyogo, Japan, 650-0047
Actively Recruiting
43
The University of Osaka Hospital_Cardiovascular medicine
Osaka, Japan, 565-0871
Actively Recruiting
44
Medical Research Institute KITANO HOSPITAL_Cardiovascular Medicine
Osaka-shi, Osaka, Japan, 530-8480
Actively Recruiting
45
Osaka Metropolitan University Hospital_Cardiovascular Medicine
Osaka-Shi, Osaka, Japan, 545-8586
Actively Recruiting
46
Sapporo Medical University Hospital_Cardiovascular, Kidney, Metabolism Endocrinology
Sapporo-shi, Hokkaido, Japan, 060-8543
Actively Recruiting
47
National Hospital Organization Yokohama Medical Center_Cardiology
Yokohama-shi, Kanagawa, Japan, 245-8575
Actively Recruiting
48
AmsterdamUMC AMC
Amsterdam, Netherlands, 1105 AZ
Actively Recruiting
49
Zuyderland ziekenhuis - Cardiologie
Heerlen, Netherlands, 6419 PC
Actively Recruiting
50
Radboudumc
Nijmegen, Netherlands, 6525 GA
Actively Recruiting
51
Erasmus MC
Rotterdam, Netherlands, 3015 GD
Actively Recruiting
52
VieCuri - Cardiologie
Venlo, Netherlands, 5912 BL
Actively Recruiting
53
4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
Wroclaw, Lower Silesian Voivodeship, Poland, 50-981
Actively Recruiting
54
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
Lublin, Lublin Voivodeship, Poland, 20-049
Not Yet Recruiting
55
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Podlaskie Voivodeship, Poland, 15-276
Not Yet Recruiting
56
Wojewodzki Szpital Specjalistyczny W Bialej Podlaskiej
Biała Podlaska, Poland, 21-500
Not Yet Recruiting
57
American Heart of Poland S.A.
Bielsko-Biala, Poland, 43-316
Not Yet Recruiting
58
Krakowski Szpital Specjalistyczny im. Jana Pawla II
Krakow, Poland, 31-202
Actively Recruiting
59
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o.
Krakow, Poland, 31-826
Actively Recruiting
60
Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie
Lublin, Poland, 20-090
Actively Recruiting
61
Wojewodzki Szpital Im. Sw.Ojca Pio W Przemyslu
Przemyśl, Poland, 37-700
Actively Recruiting
62
Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
Warsaw, Poland, 04-628
Not Yet Recruiting
63
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
Wroclaw, Poland, 50-556
Actively Recruiting
64
Chungbuk National University Hospital
Cheongju-si, South Korea, 28644
Actively Recruiting
65
Keimyung University Dongsan Hospital
Daegu, South Korea, 42601
Actively Recruiting
66
Wonju Severance Christian Hospital
Gangwon-do, South Korea, 26426
Actively Recruiting
67
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea, 13620
Completed
68
Korea University Anam Hospital
Seoul, South Korea, 02841
Actively Recruiting
69
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
70
Korea University Guro Hospital
Seoul, South Korea, 08308
Actively Recruiting
71
Korea University Guro Hospital
Seoul, South Korea, 08308
Not Yet Recruiting
72
Hospital Universitario San Cecilio
Granada, Andalusia, Spain, 18016
Actively Recruiting
73
Hospital Univ. de Gerona Doctor Josep Trueta
Girona, Catalonia, Spain, 17007
Actively Recruiting
74
Hospital Univ. Virgen de la Arrixaca
El Palmar, Murcia, Spain, 30120
Actively Recruiting
75
Hospital del Mar
Barcelona, Spain, 08003
Actively Recruiting
76
Hospital de Dénia_Cardiología
Denia, Spain, 03700
Completed
77
Hospital Virgen de la Arrixaca
El Palmar, Spain, 30120
Not Yet Recruiting
78
Hospital Univ. de Gran Canaria Doctor Negrín
Las Palmas de Gran Canaria, Spain, 35010
Not Yet Recruiting
79
Hospital Ramón y Cajal_Cardiología
Madrid, Spain, 28034
Not Yet Recruiting
80
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
81
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Spain, 28222
Not Yet Recruiting
82
H. Clinico Univ. Virgen de la Victoria
Málaga, Spain, 29010
Completed
83
Hospital Universitario Virgen del Rocío
Seville, Spain, 41013
Not Yet Recruiting
84
Hospital Clinico Universitario de Valencia
Valencia, Spain, 46010
Actively Recruiting
85
Trialmed - Midlands
Birmingham, United Kingdom, B15 2SQ
Actively Recruiting
86
Wycombe General Hospital
High Wycombe, United Kingdom, HP11 2TT
Actively Recruiting
87
St Bartholomew's Hospital - Cardiac Research Office
London, United Kingdom, EC1A 7BE
Not Yet Recruiting
88
St Bartholomew's Hospital - Cardiology
London, United Kingdom, EC1A 7BE
Not Yet Recruiting
89
Kings College Hospital
London, United Kingdom, SE5 9RS
Actively Recruiting
90
The Royal Brompton Hospital - Respiratory CRF
London, United Kingdom, SW3 6HP
Not Yet Recruiting
91
The James Cook University Hospital - Cardiology
Middlesbrough, United Kingdom, TS4 3BW
Actively Recruiting
92
Southampton General Hospital
Southampton, United Kingdom, SO16 6YD
Actively Recruiting
Research Team
N
Novo Nordisk
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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