Actively Recruiting
RESting-state Functional MRI in Patients With Optic Neuritis for ANticipation of reCovEry
Led by Fondation Ophtalmologique Adolphe de Rothschild · Updated on 2026-01-05
200
Participants Needed
1
Research Sites
336 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
When patients arrive in the waiting room of the MRI department, patients will be given the briefing note explaining the purpose of the study and how it is going. During the consultation, the radiologist will check the inclusion and non-inclusion criteria, and will take the time to answer all of the patient's questions about the study. If the patient agrees to participate in the research, the investigating doctor will obtain his consent. The MRI examination will be performed on a 3T multi-parametric MRI. Compared to the standard protocol, patients will benefit from an additional sequence of f-mRI, called resting state, and performed before injection of gadolinium contrast agent. A consultation with an ophthalmologist will also be carried out the same day, at the Adolphe de Rothschild Foundation. During this visit, an OCT examination (optical coherence tomography), a visual field as well as the measurement of visual acuity will be carried out, in accordance with the treatment usually practiced at the Adolphe de Rothschild Foundation. The subjects of the control group who agreed to participate will benefit from an MRI examination which will include, in addition to the sequences planned for these patients according to their indications, the two non-injected sequences which will be performed on patients with suspected NO. The possible existence of visual problems in the subjects of the control group will also be asked to them by interrogation. No eye exams or follow-up visits are planned, and control group participation will end after the MRI scan. Patients with NO will be seen in consultation by an ophthalmologist during a follow-up visit approximately 6 months after diagnosis. During this consultation, an OCT, a visual field and the measurement of visual acuity will be performed. This visit and the examinations carried out correspond to the usual care of patients suffering from NO and followed at the Adolphe de Rothschild Foundation Hospital.
CONDITIONS
Official Title
RESting-state Functional MRI in Patients With Optic Neuritis for ANticipation of reCovEry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years of age
- Clinical suspicion of optic neuritis
- Undergoing MRI for exploration of optic neuritis
- Affiliate or beneficiary of a social security scheme
- Provided informed information and given express consent to participate
You will not qualify if you...
- Contraindication to MRI, including pregnancy or breastfeeding
- History of amblyopia
- Any pre-existing eye disease causing vision loss (e.g., retinitis pigmentosa, age-related macular degeneration)
- Under legal protection measures
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fondation A De Rothschild
Paris, PARIS, France, 75019
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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