Study of Senescent Cells in Uterine Fibroids in Women Aged 18 to 55 Undergoing Elective Surgery

What this Trial Is About

Researchers are studying uterine fibroids, which are common tumors made up of excessive fibrous tissue in the uterus. This research focuses on the role of senescent cells, a small group of aged cells in fibroids, and how they interact with immune cells to promote tissue fibrosis. The goal is to understand these cell communication networks to help develop new treatments for uterine fibroids. Women aged 18 to 55 with fibroids who are scheduled for elective hysterectomy or myomectomy are included in the study. Tissue samples from fibroids and surrounding uterine muscle will be collected and analyzed using advanced computational methods. The study plans to create a detailed atlas quantifying different types of senescent cells over five years. Participants will provide fibroid and myometrium tissue samples during surgical procedures. Researchers will measure the amount and types of senescent cells, validate factors secreted by these cells, and assess how certain drugs affect cell growth and tissue buildup in fibroids. The study lasts up to five years, during which tissue samples and laboratory analyses will be conducted to deepen the understanding of fibroid biology and senescent cell involvement.

Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)