Actively Recruiting
Role of Senescent Cells in Uterine Fibroid Pathogenesis
Led by Johns Hopkins University · Updated on 2025-12-11
150
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
J
Johns Hopkins University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying uterine fibroids, which are common tumors made up of excessive fibrous tissue in the uterus. This research focuses on the role of senescent cells, a small group of aged cells in fibroids, and how they interact with immune cells to promote tissue fibrosis. The goal is to understand these cell communication networks to help develop new treatments for uterine fibroids. Women aged 18 to 55 with fibroids who are scheduled for elective hysterectomy or myomectomy are included in the study. Tissue samples from fibroids and surrounding uterine muscle will be collected and analyzed using advanced computational methods. The study plans to create a detailed atlas quantifying different types of senescent cells over five years. Participants will provide fibroid and myometrium tissue samples during surgical procedures. Researchers will measure the amount and types of senescent cells, validate factors secreted by these cells, and assess how certain drugs affect cell growth and tissue buildup in fibroids. The study lasts up to five years, during which tissue samples and laboratory analyses will be conducted to deepen the understanding of fibroid biology and senescent cell involvement.
CONDITIONS
Brief Title
Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 55 years
- Women with suspected uterine fibroids
- Women who are or have been sexually active or have had a previous vaginal exam with a speculum
- Ability to understand, read, and speak English or Spanish and consent to procedures and use of health information
You will not qualify if you...
- Unwillingness to sign the consent form or complete questionnaires
- Current pregnancy
- Cancer of the uterus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to time of elective surgery
Participants undergo evaluation related to their uterine fibroids and planned elective surgery.
1 to 2 visits depending on surgical scheduling
Duration - Day of surgery and immediate recovery period
Participants undergo elective hysterectomy or myomectomy with collection of fibroid and myometrium tissue samples for analysis.
1 surgical visit and immediate post-operative assessment
Duration - Up to 5 years
Participants are observed for development of senescent cell markers and fibrosis progression through tissue analyses.
Follow-up visits as per routine clinical care; no additional trial visits required
Trial Site Locations
Total: 1 location
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
J
James Segars, MD
B
Bhuchitra Singh, MD, MPH, MBA
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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