What is this study trying to find out about Alzheimer's Disease?

This study is aiming to find individuals who might be eligible for further Alzheimer's Disease research studies by measuring specific blood biomarkers and cognitive function. It helps identify potential participants for more extensive clinical trials. Participants will be evaluated for key indicators that relate to Alzheimer's disease progression.

Who may be eligible for this Alzheimer's Disease clinical trial?

Adults aged 50 to 90 years who are willing and able to participate in an interventional study may be eligible. Participants should not have significant daily living impairments from cognitive issues or other neurological diseases besides Alzheimer's. Please review eligibility criteria for more details.

Is there any cost to participate in this Alzheimer's Disease clinical trial?

Study-related care, including all tests and study visits, is provided at no cost. However, personal travel expenses to and from study sites may vary and are not guaranteed to be covered.

Actively Recruiting

Phase 3

Age: 50Years - 90Years

All Genders

ID07177352

Screening Study to Identify Candidates for Roche Alzheimers Disease Trials Based on Blood Biomarkers and Cognitive Testing

Led by Hoffmann-La Roche · Updated on 2026-07-24

80000

Participants Needed

211

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to identify individuals who may be eligible for interventional studies related to Alzheimers Disease by assessing specific biomarkers and cognitive performance. It is a Phase 3 screening study sponsored by Hoffmann-La Roche designed to evaluate potential participants using blood tests and cognitive assessments. The study focuses on adults aged 50 to 90 years to find candidates for further Alzheimers disease research. Participants will not receive any treatment but will undergo blood draws to measure the concentration of the biomarker pTau217. They will also complete the International Shopping List Test ISLT to assess cognitive function. This screening process helps determine eligibility for linked interventional Alzheimers disease studies by combining biomarker and cognitive data. During the study, participants will provide blood samples and perform cognitive tests at the initial visit. Researchers will measure the pTau217 levels in blood and record cognitive scores from the ISLT. The study involves no experimental treatment, focusing solely on assessment. Participation lasts until the primary completion date, with data collected on Day 1 to evaluate potential eligibility for further trials.

CONDITIONS

Brief Title

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

Who Can Participate

Age: 50Years - 90Years

All Genders

Eligibility Criteria

You may qualify if you...

Ability and willingness to participate in an interventional clinical study, including meeting key eligibility criteria of linked interventional Roche AD studies (e.g., specific age ranges)
Ability and willingness to receive information about potential eligibility in an associated interventional Roche AD study

You will not qualify if you...

Dependency in basic activities of daily living (bADLs) due to cognitive impairment
Visual or auditory impairment that would prevent them from performing the cognitive assessments (eyeglasses and hearing aids are permitted)
Any self-reported evidence or known diagnosis of a neurological or neurodegenerative condition that may lead to cognitive impairment other than AD
History of severe, clinically significant central nervous system trauma
Any serious medical condition that precludes a participant's safe participation and completion of a clinical study
For participants with a clinical diagnosis of MCI or mild AD: Previous AD diagnosis based on biomarker confirmation with an approved or validated rule in method (e.g., amyloid PET or cerebrospinal fluid, blood biomarker) is exclusionary

Research Team

Reference Study ID Number: WP45722 https://forpatients.roche.com/ No attachments to email below.

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

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Screening Study to Identify Candidates for Roche Alzheimers Disease Trials Based on Blood Biomarkers and Cognitive Testing

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Research Team

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria