Actively Recruiting
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Led by Arizona State University · Updated on 2026-05-05
216
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
A
Arizona State University
Lead Sponsor
B
Banner Alzheimer's Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.
CONDITIONS
Official Title
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of mild cognitive impairment or probable/possible mild Alzheimer's disease dementia according to 2011 Alzheimer's association-NIA criteria
- Community-dwelling, such as living at home or in assisted living
- Age 65 years and older
- Medical clearance from primary care provider or cardiovascular specialist
- Have a qualified study partner
- Agree to blood draws
- Verified safe for MRI scanning
- Study partner aged 18 or older
- Study partner has contact with participant at least twice per week for 6 months or more
- Study partner knows participant's memory status and daily living abilities
- Study partner consents to participant's involvement
You will not qualify if you...
- Resting heart rate less than or equal to 50 or greater than or equal to 100 beats per minute after 5 minutes of quiet resting
- American College of Sports Medicine contraindications to exercise
- New or unevaluated symptoms or diseases not yet assessed by a healthcare provider
- Abnormal cardiac condition found during VO2peak testing
- Currently enrolled in another intervention aiming to improve cognition
- Moderate to strenuous exercise 150 minutes or more per week in the past 6 months
- Taking two or more anti-depression medications or having poorly managed or unstable depression
- Poorly managed or unstable anxiety
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Arizona State University
Phoenix, Arizona, United States, 85004
Actively Recruiting
Research Team
K
Kristi Spieleder, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
4
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