Study of Laser Speckle Contrast Imaging to Monitor Blood Flow Before, During, and After Lower Leg Revascularization in Adults with Peripheral Vascular Disease

What this Trial Is About

Researchers are evaluating the use of Laser Speckle Contrast Imaging LSCI to monitor blood flow in the lower legs before, during, and after revascularization surgery in adults with peripheral artery disease. This condition involves blocked arteries in the legs, causing symptoms from pain while walking to ulcers. The study aims to see if LSCI is a feasible, non-invasive method for assessing tissue blood flow compared to current techniques, which can be invasive and less practical for outpatient use. Participants will undergo LSCI measurements during the perioperative period and after surgery. The study will compare LSCI results with foot temperature and the standard near-infrared fluorescence imaging using indocyanine green dye. The researchers will also explore new ways to analyze LSCI data, such as measuring blood flow pulsatility, to better understand perfusion changes related to surgery. During the study, participants will have quick LSCI scans lasting 5 to 10 seconds at different times around their revascularization procedure. These scans are safe and use low-intensity laser light that does not harm the skin. The study will track LSCI measurements alongside routine clinical assessments and foot temperature readings. The main goal is to measure how well LSCI can quantify blood flow changes in the legs, with follow-up lasting up to two years to correlate findings with clinical outcomes.

SPECTATOR: Perfusion Monitoring Before, During and After Lower Extremity Revascularization With Laser Speckle Contrast Imaging