Actively Recruiting

Age: 18Years +
All Genders
NCT07397585

stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database

Led by Istituto Clinico Humanitas · Updated on 2026-02-11

300

Participants Needed

28

Research Sites

96 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases. In addition to standard treatments that act on the whole body, such as chemotherapy or hormonal therapy, these patients might also benefit from local treatments that directly target the cancer spots. One of these local treatments is stereotactic body radiotherapy (SBRT), a non-invasive radiation treatment that delivers high doses of radiation in a few sessions. In the past, most of the evidence about the benefit of local treatments came from surgery. More recently, there has been growing interest in SBRT because it does not require surgery. However, the results of studies so far have not been consistent.The goal of this multicenter retrospective study is to better understand whether SBRT can improve disease control and survival in patients with breast cancer that has spread to a limited number of sites outside the brain.

CONDITIONS

Official Title

stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients 18 years or older
  • Histological diagnosis of breast cancer
  • Oligometastatic or oligoprogressive metastatic breast cancer
  • Received SBRT with a minimum dose of 50Gy EQD2 in a maximum of 12 fractions as per Oligocare definition
  • Ability to provide written informed consent
Not Eligible

You will not qualify if you...

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 28 locations

1

Aorn San Pio

Benevento, Benevento, Italy, 82100

Not Yet Recruiting

2

Humanitas Gavazzeni

Bergamo, Bergamo, Italy, 24125

Actively Recruiting

3

Ospedale Perrino

Brindisi, BR, Italy, 72100

Not Yet Recruiting

4

Spedali Civili

Brescia, BS, Italy, 25123

Actively Recruiting

5

Responsible Research Hospital

Campobasso, CB, Italy, 86100

Actively Recruiting

6

Azienda Ospedaliera Universitaria Careggi

Florence, Firenze, Italy, 50134

Not Yet Recruiting

7

Irccs Ospedale Policlinico San Martino

Genova, Genova, Italy, 16132

Not Yet Recruiting

8

A.O.U. "G. Martino" - Università degli Studi di Messina

Messina, Messina, Italy, 98124

Not Yet Recruiting

9

Fondazione I.R.C.C.S Istituto Nazionale Tumori di Milano

Milan, MILANO, Italy, 20133

Actively Recruiting

10

IEO

Milan, Milano, Italy, 20141

Not Yet Recruiting

11

IRCCS Humanitas Research Humanitas

Rozzano, MILANO, Italy, 20089

Actively Recruiting

12

IRCCS Ospedale San Raffaele

Milan, Milan, Italy, 20132

Not Yet Recruiting

13

INT IRCCS Fondazione G. Pascale

Naples, Napoli, Italy, 80131

Actively Recruiting

14

Ospedale Maggiore della Carita

Novara, NOVARA, Italy, 28100

Actively Recruiting

15

Civico Palermo

Palermo, Palermo, Italy, 90127

Not Yet Recruiting

16

Istituto Oncologico Veneto

Padova, PD, Italy, 35128

Not Yet Recruiting

17

Azienda Ospedaliera Universitaria Pisana

Pisa, PI, Italy, 56124

Not Yet Recruiting

18

IRCCS Centro di Riferimento Oncologico di Aviano

Aviano, Pordenone, Italy, 33081

Not Yet Recruiting

19

Uo Radioterapia Aor San Carlo

Potenza, PZ, Italy, 85100

Not Yet Recruiting

20

Irccs Crob

Rionero in Vulture, PZ, Italy, 85028

Actively Recruiting

21

UOC Radioterapia Ospedale San Filippo Neri

Roma, RM, Italy, 00135

Not Yet Recruiting

22

Azienda Ospedaliera San Giovanni Addolorata

Roma, RM, Italy, 00184

Not Yet Recruiting

23

Fondazione Policlinico Universitario, Campus-Biomedico

Roma, Roma, Italy, 00128

Actively Recruiting

24

Fondazione PTV Policlinico Tor Vergata

Roma, Roma, Italy, 00133

Not Yet Recruiting

25

Azienda Ospedaliera Sant'Andrea

Roma, Roma, Italy, 00189

Not Yet Recruiting

26

S.C. Radioterapia Oncologica ASL Taranto

Taranto, Taranto, Italy, 74100

Not Yet Recruiting

27

Radioterapia Oncologica - Ospedale Sanata Chiara

Trento, TRENTO, Italy, 38122

Not Yet Recruiting

28

S.C. Radioterapia Oncologica - Azienda Ospedaliera Santa Maria Terni

Terni, TR, Italy, 05100

Not Yet Recruiting

Loading map...

Research Team

R

Ruggero Spoto, MD, Radiation oncologist

CONTACT

L

Laura Bonavita, Master Degree

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here