Actively Recruiting
stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database
Led by Istituto Clinico Humanitas · Updated on 2026-02-11
300
Participants Needed
28
Research Sites
96 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Oligometastatic breast cancer is a condition in which breast cancer has spread to a small number of other parts of the body. Patients with this type of disease may live longer than those with more widespread metastases. In addition to standard treatments that act on the whole body, such as chemotherapy or hormonal therapy, these patients might also benefit from local treatments that directly target the cancer spots. One of these local treatments is stereotactic body radiotherapy (SBRT), a non-invasive radiation treatment that delivers high doses of radiation in a few sessions. In the past, most of the evidence about the benefit of local treatments came from surgery. More recently, there has been growing interest in SBRT because it does not require surgery. However, the results of studies so far have not been consistent.The goal of this multicenter retrospective study is to better understand whether SBRT can improve disease control and survival in patients with breast cancer that has spread to a limited number of sites outside the brain.
CONDITIONS
Official Title
stereOtactic Body RadIothErapy for exTracranial oligomeTastAtic Breast Cancer: Multi Institutional Retrospective Database
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- Histological diagnosis of breast cancer
- Oligometastatic or oligoprogressive metastatic breast cancer
- Received SBRT with a minimum dose of 50Gy EQD2 in a maximum of 12 fractions as per Oligocare definition
- Ability to provide written informed consent
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
Aorn San Pio
Benevento, Benevento, Italy, 82100
Not Yet Recruiting
2
Humanitas Gavazzeni
Bergamo, Bergamo, Italy, 24125
Actively Recruiting
3
Ospedale Perrino
Brindisi, BR, Italy, 72100
Not Yet Recruiting
4
Spedali Civili
Brescia, BS, Italy, 25123
Actively Recruiting
5
Responsible Research Hospital
Campobasso, CB, Italy, 86100
Actively Recruiting
6
Azienda Ospedaliera Universitaria Careggi
Florence, Firenze, Italy, 50134
Not Yet Recruiting
7
Irccs Ospedale Policlinico San Martino
Genova, Genova, Italy, 16132
Not Yet Recruiting
8
A.O.U. "G. Martino" - Università degli Studi di Messina
Messina, Messina, Italy, 98124
Not Yet Recruiting
9
Fondazione I.R.C.C.S Istituto Nazionale Tumori di Milano
Milan, MILANO, Italy, 20133
Actively Recruiting
10
IEO
Milan, Milano, Italy, 20141
Not Yet Recruiting
11
IRCCS Humanitas Research Humanitas
Rozzano, MILANO, Italy, 20089
Actively Recruiting
12
IRCCS Ospedale San Raffaele
Milan, Milan, Italy, 20132
Not Yet Recruiting
13
INT IRCCS Fondazione G. Pascale
Naples, Napoli, Italy, 80131
Actively Recruiting
14
Ospedale Maggiore della Carita
Novara, NOVARA, Italy, 28100
Actively Recruiting
15
Civico Palermo
Palermo, Palermo, Italy, 90127
Not Yet Recruiting
16
Istituto Oncologico Veneto
Padova, PD, Italy, 35128
Not Yet Recruiting
17
Azienda Ospedaliera Universitaria Pisana
Pisa, PI, Italy, 56124
Not Yet Recruiting
18
IRCCS Centro di Riferimento Oncologico di Aviano
Aviano, Pordenone, Italy, 33081
Not Yet Recruiting
19
Uo Radioterapia Aor San Carlo
Potenza, PZ, Italy, 85100
Not Yet Recruiting
20
Irccs Crob
Rionero in Vulture, PZ, Italy, 85028
Actively Recruiting
21
UOC Radioterapia Ospedale San Filippo Neri
Roma, RM, Italy, 00135
Not Yet Recruiting
22
Azienda Ospedaliera San Giovanni Addolorata
Roma, RM, Italy, 00184
Not Yet Recruiting
23
Fondazione Policlinico Universitario, Campus-Biomedico
Roma, Roma, Italy, 00128
Actively Recruiting
24
Fondazione PTV Policlinico Tor Vergata
Roma, Roma, Italy, 00133
Not Yet Recruiting
25
Azienda Ospedaliera Sant'Andrea
Roma, Roma, Italy, 00189
Not Yet Recruiting
26
S.C. Radioterapia Oncologica ASL Taranto
Taranto, Taranto, Italy, 74100
Not Yet Recruiting
27
Radioterapia Oncologica - Ospedale Sanata Chiara
Trento, TRENTO, Italy, 38122
Not Yet Recruiting
28
S.C. Radioterapia Oncologica - Azienda Ospedaliera Santa Maria Terni
Terni, TR, Italy, 05100
Not Yet Recruiting
Research Team
R
Ruggero Spoto, MD, Radiation oncologist
CONTACT
L
Laura Bonavita, Master Degree
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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