Actively Recruiting
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
Led by Peter C. Gerszten, MD · Updated on 2026-03-05
15
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.
CONDITIONS
Official Title
Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ages between 21 and 75 years
- Control subjects undergoing elective posterior cervical spinal surgery with decompressive laminectomy and electrophysiological monitoring as standard care
- Stroke subjects with single ischemic or hemorrhagic stroke more than 6 months ago causing hemiparesis, undergoing cervical epidural lead implant or elective posterior cervical spinal surgery with electrophysiological monitoring
You will not qualify if you...
- Known neurological diseases other than stroke affecting cervical sensory afferents, such as amyotrophic lateral sclerosis, spinal muscular atrophy, spinal cord injury, autoimmune neuropathy, or sensory nerve disorders
- Not eligible for surgery, including pregnancy and other clinical conditions
- Use of anti-spasticity or anti-epileptic medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
Research Team
P
Peter C Gerszten, MD
CONTACT
E
Elvira Pirondini, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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