Actively Recruiting
The Principle of Stimulus Equivalence Learning and Its Neuropsychological Correlates in Adults With Acquired Brain Injury (ABI)
Led by Klimmendaal Revalidatiespecialisten · Updated on 2026-05-22
40
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
Sponsors
K
Klimmendaal Revalidatiespecialisten
Lead Sponsor
D
Donders Centre for Cognitive Neuroimaging
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating Stimulus Equivalence Learning (SEL), a type of implicit learning where different stimuli become linked in memory without direct teaching, in adults with Acquired Brain Injury (ABI), which includes conditions like stroke and traumatic brain injury. The study aims to understand how ABI might affect the ability to acquire SEL, a concept rarely used in cognitive rehabilitation after such injuries. This research is observational and led by Klimmendaal Revalidatiespecialisten. The study involves comparing adults with ABI to healthy controls. Participants will be assessed using various cognitive and memory tests on the first day, including the Modified Rutgers Equivalence Learning Task (mRAET), Location Learning Test, digit span tasks from the Wechsler Adult Intelligence Scale, and other neuropsychological assessments. There are no investigational treatments or interventions; instead, the focus is on measuring cognitive functions related to SEL. Participants will undergo a series of memory, attention, and learning tests during a single study visit. Researchers will collect data from these assessments to evaluate the participants' cognitive abilities and their relation to stimulus equivalence learning. The study concludes after this evaluation, with no long-term treatment or follow-up involved. The total participation time is limited to the testing day.
CONDITIONS
Brief Title
Stimulus Equivalence Learning in Acquired Brain Injury.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Diagnosed with acquired brain injury (ABI) more than 3 months ago, including stroke, traumatic brain injury, brain tumor, encephalitis, or out-of-hospital cardiac arrest (OHCA)
- Able to understand and communicate in Dutch
- Sufficient cognitive ability to complete study tests
You will not qualify if you...
- Presence of neurodegenerative disorders
- Severe psychiatric disorders, including suicidality
- Severe cognitive impairments, aphasia, or visual/hearing problems that prevent test completion
- For healthy controls: any medical condition causing cognitive impairment beyond normal aging, including stroke, TBI, brain tumor, or other brain injury
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants complete a series of cognitive and neuropsychological tests to assess stimulus equivalence learning and related functions.
1 visit (in-person)
Duration - Up to study completion in July 2026
Participants may be observed over time to understand the neuropsychological correlates of acquired brain injury.
Additional assessments may occur depending on cohort assignment
Trial Site Locations
Total: 1 location
1
Klimmendaal Revalidatiespecialisten
Arnhem, Gelderland, Netherlands, 6813 GG
Actively Recruiting
Research Team
E
Edo Grevers, MSc.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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