Actively Recruiting
Structural-functional Connectome With High-density Electroencephalography in Drug-resistant Epilepsies and Rare Neurodevelopmental Syndromes With Epilepsy
Led by IRCCS Eugenio Medea · Updated on 2024-04-09
120
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the brain's functional and structural organization in people with drug-resistant epilepsy and rare neurodevelopmental syndromes like Angelman syndrome and Dup15q syndrome. By analyzing signals from high-density electroencephalography (HD-EEG) and structural MRI, this study aims to understand how brain networks reorganize before and after drug or surgical treatments. The goal is to find markers that reflect clinical changes and help monitor cognitive and behavioral development over time. Participants undergo noninvasive assessments including resting state HD-EEG with 128 channels and neuropsychological evaluations. These tests are used to analyze brain connectivity and its relationship to cognitive and behavioral function. The study looks at changes in brain network organization over two years, especially focusing on those who achieve seizure freedom or significant seizure reduction after treatment. During the study, participants will have repeated EEG and MRI data collected, alongside neuropsychological tests. Researchers will measure differences in brain network coherence, stability of brain activity frequency bands, and the link between neural excitation and memory performance over two years. This longitudinal approach aims to provide a dynamic view of clinical evolution in these conditions, helping to identify syndrome-specific brain function markers and improve patient care.
CONDITIONS
Brief Title
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of focal or generalized epilepsy, Angelman syndrome, or Dup15q syndrome confirmed by a specialist
- At least one brain MRI scan including 3D T1 sequences
- At least one 128-channel high-density EEG recording
- Age between 6 and 75 years at the time of evaluation
- Ability to participate in a neuropsychological evaluation
You will not qualify if you...
- Epilepsy caused by vascular issues or non-low-grade tumors
- Age outside the range of 6 to 75 years
- Incomplete neuroradiological exam (missing T1 3D sequences)
- Absence of 128-channel high-density EEG recording
- Inability to participate in a neuropsychological evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 years
Participants undergo noninvasive assessments including high-density EEG recordings and neuropsychological evaluations to characterize brain functional and structural connectivity.
Repeated visits over 2 years depending on clinical follow-up schedule
Duration - Up to 2 years
Participants are monitored longitudinally to observe changes in brain network organization and cognitive/behavioral functioning following treatment or over time.
Periodic visits for assessments during the 2-year observation period
Trial Site Locations
Total: 1 location
1
IRCCS E.Medea
Conegliano, Treviso, Italy, 31015
Actively Recruiting
Research Team
G
Gian Marco Duma, PhD
D
Darling Boachie
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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