Actively Recruiting
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Led by IRCCS Eugenio Medea · Updated on 2024-04-09
120
Participants Needed
1
Research Sites
158 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Recent studies have shown that the aperiodic part of the signal (neuronal avalanches) of electroencephalography (EEG) contains important information about the dynamics of neuronal networks. Indeed, this has helped to identify functionally altered areas in patients with temporal epilepsy by simply using the resting EEG signal. Furthermore, it has been seen that the propagation of neuronal avalanches (VNs) correlates with the morphological organization of the cerebral cortex. Therefore, NAs represent a measure with direct utility for studying functional reorganization pre and post drug/surgical treatment. In addition, the aperiodic portion of the signal may represent a noninvasive measure of the excitation/inhibition relationship, which is known of being altered both in epilepsy and in some rare neurodevelopmental syndromes (example: Angelman and Dup15q)
CONDITIONS
Official Title
Structural-functional Connectome in Drug-resistant Epilepsies and Neurodevelopmental Syndromes With Epilepsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of focal or generalized epilepsy, Angelman syndrome, or Dup15q syndrome confirmed by a specialist
- At least one brain MRI scan including 3D T1 sequences
- At least one 128-channel high-density EEG recording
- Age between 6 and 75 years at the time of evaluation
- Ability to participate in a neuropsychological evaluation
You will not qualify if you...
- Epilepsy caused by vascular issues or non-low-grade tumors
- Age outside the range of 6 to 75 years
- Incomplete neuroradiological exams lacking 3D T1 sequences
- No 128-channel high-density EEG recording available
- Inability to participate in a neuropsychological evaluation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS E.Medea
Conegliano, Treviso, Italy, 31015
Actively Recruiting
Research Team
G
Gian Marco Duma, PhD
CONTACT
D
Darling Boachie
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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