Actively Recruiting
A Study of AK138D1 in Advanced Malignant Tumors
Led by Akeso · Updated on 2025-12-15
200
Participants Needed
1
Research Sites
135 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase I clinical trial testing the safety and effectiveness of AK138D1in patients with advanced cancer. The study will enroll up to 200 patients with various types of advanced solid tumors who haven't responded to standard treatments. Patients will receive AK138D1 to determine the safest dose and evaluate if the drug can help treat their cancer.
CONDITIONS
Official Title
A Study of AK138D1 in Advanced Malignant Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed written informed consent form voluntarily
- Age between 18 and 75 years, male or female
- ECOG performance status score of 0 or 1
- Life expectancy of at least 3 months
- At least 1 measurable lesion suitable for repeated measurement
- Adequate organ function
You will not qualify if you...
- Prior HER3-targeted therapies, including antibodies, ADCs, or CAR-T
- Participation in another interventional clinical study concurrently
- Active central nervous system (CNS) metastases
- Live or attenuated vaccines administered within 4 weeks before first dose or planned during study
- Untreated active hepatitis B or C
- Known active pulmonary tuberculosis
- Known active syphilis infection
- Allergy to any study drug components or severe hypersensitivity to other monoclonal antibodies
- Other ineligibility reasons as determined by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China
Actively Recruiting
Research Team
W
Wenting Li, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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