Actively Recruiting
Study of CAR-T Therapy in Older Patients
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-07
154
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life. This is a quality of life study and participating in the study does not involve receiving any treatment, other than the standard treatment for participants' disease.
CONDITIONS
Official Title
Study of CAR-T Therapy in Older Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older
- Diagnosed with relapsed or refractory lymphoid malignancy or plasma cell disorder and receiving commercial CAR T-cell therapy
- Able to speak and understand English (only for certain study groups)
- MoCA score less than 26 out of 30 during geriatric assessment before CAR T treatment (only for certain study groups)
You will not qualify if you...
- Any prior commercial or investigational CAR T therapy
- Current diagnosis of major psychiatric disorders including major depression, bipolar disorder, or schizophrenia (only for certain study groups)
- History of neurological disorders, neurodegenerative diseases, or traumatic brain injury with extended loss of consciousness (only for certain study groups)
- Current or past substance abuse (only for certain study groups)
- History of central nervous system disease (only for certain study groups)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
Research Team
R
Richard Lin, MD, PhD
CONTACT
S
Sergio Giralt, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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