Actively Recruiting
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
Led by Arcus Biosciences, Inc. · Updated on 2026-05-14
720
Participants Needed
97
Research Sites
272 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to evaluate the progression-free survival (PFS) of casdatifan versus placebo when each is given in combination with cabozantinib in adult patients with confirmed advanced or metastatic clear cell Renal Cell Carcinoma who have experienced progression on or after prior anti-PD-1 or anti-PD-L1 immunotherapy.
CONDITIONS
Official Title
Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Unresectable and measurable locally advanced or metastatic renal cell carcinoma with a primary clear cell component.
- Karnofsky Performance Status (KPS) score of 80% or higher.
- At least one target lesion measurable by CT or MRI per RECIST 1.1, not in a prior radiation field.
- Adequate organ and marrow function within 1 week before randomization.
- Women of childbearing potential must have a negative serum pregnancy test.
You will not qualify if you...
- Prior treatment with a HIF-2 alpha inhibitor or cabozantinib.
- Another active malignancy within the past year except for locally curable cancers that appear cured.
- Ongoing significant toxicities from prior anticancer treatments or Grade 3 or higher toxicities regardless of cause.
- Uncontrolled or poorly controlled hypertension (blood pressure over 150/90 mmHg) despite treatment.
- History of leptomeningeal disease or spinal cord compression.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 97 locations
1
Research Site
Gilbert, Arizona, United States, 85234
Actively Recruiting
2
Research Site
Goodyear, Arizona, United States, 85338
Actively Recruiting
3
Research Site
Phoenix, Arizona, United States, 85054
Actively Recruiting
4
Research Site
Duarte, California, United States, 91010
Actively Recruiting
5
Research Site
La Jolla, California, United States, 92103
Actively Recruiting
6
Research Site
Los Angeles, California, United States, 90095
Actively Recruiting
7
Research Site
Sacramento, California, United States, 95817
Actively Recruiting
8
Research Site
San Diego, California, United States, 92103
Actively Recruiting
9
Research Site
New Haven, Connecticut, United States, 06519
Actively Recruiting
10
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
11
Research Site
Miami, Florida, United States, 33136
Actively Recruiting
12
Research Site
Orlando, Florida, United States, 32804
Actively Recruiting
13
Research Site
Atlanta, Georgia, United States, 30318
Actively Recruiting
14
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
15
Research Site
Newnan, Georgia, United States, 30265
Actively Recruiting
16
Research Site
Zion, Illinois, United States, 60099
Actively Recruiting
17
Research Site
Indianapolis, Indiana, United States, 46202
Actively Recruiting
18
Research Site
Louisville, Kentucky, United States, 40207
Actively Recruiting
19
Research Site
Jefferson, Louisiana, United States, 70121
Actively Recruiting
20
Research Site
Baltimore, Maryland, United States, 21287
Actively Recruiting
21
Research Site
Boston, Massachusetts, United States, 02114
Actively Recruiting
22
Research Site
Boston, Massachusetts, United States, 02215
Actively Recruiting
23
Research Site
Rochester, Minnesota, United States, 55905
Actively Recruiting
24
Research Site
St Louis, Missouri, United States, 63110
Actively Recruiting
25
Research Site
Omaha, Nebraska, United States, 68198
Actively Recruiting
26
Research Site
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
27
Research Site
Buffalo, New York, United States, 14263
Actively Recruiting
28
Research Site
Rochester, New York, United States, 14642
Actively Recruiting
29
Research Site
Chapel Hill, North Carolina, United States, 27514
Actively Recruiting
30
Research Site
Cleveland, Ohio, United States, 44106
Actively Recruiting
31
Research Site
Portland, Oregon, United States, 97212
Actively Recruiting
32
Research Site
Monroeville, Pennsylvania, United States, 15146
Actively Recruiting
33
Research Site
Charleston, South Carolina, United States, 29425
Actively Recruiting
34
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
35
Research Site
Nashville, Tennessee, United States, 37232
Actively Recruiting
36
Research Site
Dallas, Texas, United States, 75390
Actively Recruiting
37
Research Site
Lubbock, Texas, United States, 79430
Actively Recruiting
38
Research Site
Salt Lake City, Utah, United States, 84112
Actively Recruiting
39
Research Site
Charlottesville, Virginia, United States, 22903
Actively Recruiting
40
Research Site
Seattle, Washington, United States, 98109
Actively Recruiting
41
Research Site
Chermside, Australia
Actively Recruiting
42
Research Site
Hobart, Australia
Actively Recruiting
43
Research Site
Kurralta Park, Australia
Actively Recruiting
44
Research Site
Subiaco, Australia
Actively Recruiting
45
Research Site
Montreal, Canada
Actively Recruiting
46
Research Site
Toronto, Canada
Actively Recruiting
47
Research Site
Prague, Czechia
Actively Recruiting
48
Research Site
Angers, France
Actively Recruiting
49
Research Site
Brest, France
Actively Recruiting
50
Research Site
Montpellier, France
Actively Recruiting
51
Research Site
Paris, France
Actively Recruiting
52
Research Site
Poitiers, France
Actively Recruiting
53
Research Site
Rennes, France
Actively Recruiting
54
Research Site
Strasbourg, France
Actively Recruiting
55
Research Site
Villejuif, France
Actively Recruiting
56
Research Site
Berlin, Germany
Actively Recruiting
57
Research Site
Dresden, Germany
Actively Recruiting
58
Research Site
Frankfurt, Germany
Actively Recruiting
59
Research Site
Halle, Germany
Actively Recruiting
60
Research Site
Rostock, Germany
Actively Recruiting
61
Research Site
Terni, Italy
Actively Recruiting
62
Research Site
Nijmegen, Netherlands
Actively Recruiting
63
Research Site
Rotterdam, Netherlands
Actively Recruiting
64
Research Site
Zwolle, Netherlands
Actively Recruiting
65
Research Site
Auckland, New Zealand
Actively Recruiting
66
Research Site
Christchurch, New Zealand
Actively Recruiting
67
Research Site
Krakow, Poland
Actively Recruiting
68
Research Site
Otwock, Poland
Actively Recruiting
69
Research Site
Poznan, Poland
Actively Recruiting
70
Research Site
Rzeszów, Poland
Actively Recruiting
71
Research Site
Skorzewo, Poland
Actively Recruiting
72
Research Site
Tomaszów Mazowiecki, Poland
Actively Recruiting
73
Research Site
Craiova, Romania
Actively Recruiting
74
Research Site
Suceava, Romania
Actively Recruiting
75
Research Site
Timișoara, Romania
Actively Recruiting
76
Research Site
Busan, South Korea
Actively Recruiting
77
Research Site
Daejeon, South Korea
Actively Recruiting
78
Research Site
Goyang, South Korea
Actively Recruiting
79
Research Site
Seongnam, South Korea
Actively Recruiting
80
Research Site
Seoul, South Korea
Actively Recruiting
81
Research Site
Suwon, South Korea
Actively Recruiting
82
Research Site
Barcelona, Spain
Actively Recruiting
83
Research Site
Córdoba, Spain
Actively Recruiting
84
Research Site
Madrid, Spain
Actively Recruiting
85
Research Site
Santander, Spain
Actively Recruiting
86
Research Site
Seville, Spain
Actively Recruiting
87
Research Site
Vigo, Spain
Actively Recruiting
88
Research Site
Cambridge, United Kingdom
Actively Recruiting
89
Research Site
Exeter, United Kingdom
Actively Recruiting
90
Research Site
Glasgow, United Kingdom
Actively Recruiting
91
Research Site
Leeds, United Kingdom
Actively Recruiting
92
Research Site
London, United Kingdom
Actively Recruiting
93
Research Site
Manchester, United Kingdom
Actively Recruiting
94
Research Site
Preston, United Kingdom
Actively Recruiting
95
Research Site
Southampton, United Kingdom
Actively Recruiting
96
Research Site
Sutton, United Kingdom
Actively Recruiting
97
Research Site
Truro, United Kingdom
Actively Recruiting
Research Team
M
Medical Director
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here