Systemic lupus erythematosus.
George C Tsokos
https://pubmed.ncbi.nlm.nih.gov/22129255Actively Recruiting
Age: 1Month - 18Years
All Genders
ID06491602
A Study of Clinical Characteristics, Risk Factors, and Outcome of Lupus Nephritis Among Children With Systemic Lupus Erythematosus at Sohag University Hospital
Led by Sohag University · Updated on 2024-07-09
30
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Systemic lupus erythematosus is an autoimmune condition that causes inflammation and can affect multiple organs, often following a chronic course with unpredictable flare-ups. Kidney involvement, known as lupus nephritis, is a common and serious complication in children with this disease. This research aims to study the clinical features, risk factors, and outcomes related to lupus nephritis in children treated at Sohag University Hospital. The study is observational and involves analyzing the kidney tissue through a renal biopsy to determine the extent of kidney damage. Researchers will use this information to assess disease severity and progression. There is no intervention treatment being tested; instead, the study collects diagnostic data to better understand the condition. Participants will be children diagnosed with systemic lupus erythematosus who undergo clinical evaluations and renal biopsy analysis. The main outcomes measured include remission of lupus nephritis and progression to chronic kidney disease over one year. The study will follow participants to monitor these outcomes and gather information on clinical characteristics and risk factors.
CONDITIONS
Brief Title
A Study of Clinical Characteristics ,Risk Factors and Outcome of Lupus Nephritis Among Children With Systemic Lupus Erthromatousus in Sohag Univeristy Hospital
Who Can Participate
Age: 1Month - 18Years
All Genders
Eligibility Criteria
You may qualify if you...
- Children who meet diagnostic criteria for systemic lupus erythematosus
You will not qualify if you...
- Children with other rheumatological disorders
- Neonates
- Children with other kidney disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - 1 day
Participants undergo renal biopsy to analyze kidney tissue and determine the grade of renal affection.
1 visit (in-person)
Long-term Monitoring
Duration - 1 year
Participants are observed over time to assess remission of lupus nephritis and progression to chronic kidney disease.
Periodic visits during 1 year
Trial Site Locations
Total: 1 location
1
Sohag university Hospital
Sohag, Egypt, Sohag
Actively Recruiting
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Research Team
R
randa A ali, resident
D
dr monser M Mohammed, assistant professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population.
Linda T Hiraki, Candace H Feldman, Jun Liu...
https://pubmed.ncbi.nlm.nih.gov/22847366Long-term renal survival of paediatric patients with lupus nephritis.
Selcan Demir, Bora Gülhan, Seza Özen...
https://pubmed.ncbi.nlm.nih.gov/33826705Clinical and laboratory characteristics and long-term outcome of pediatric systemic lupus erythematosus: a longitudinal study.
Linda T Hiraki, Susanne M Benseler, Pascal N Tyrrell...
https://pubmed.ncbi.nlm.nih.gov/18346514