Actively Recruiting
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Led by Bristol-Myers Squibb · Updated on 2026-05-11
530
Participants Needed
184
Research Sites
340 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The Purpose of the Study is to Compare the Efficacy and Safety of BMS-986489 (Anti-fucosyl-GM1+ Nivolumab Fixed Dose Combination) in Combination with Carboplatin plus Etoposide to that of Atezolizumab with Carboplatin plus Etoposide as First-Line Therapy in Participants with Extensive-Stage Small Cell Lung Cancer.
CONDITIONS
Official Title
A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of extensive-stage small cell lung cancer
- Healthy enough to perform normal activities with little or no help based on ECOG performance scale
- At least one measurable tumor outside the brain and nervous system detectable by imaging such as CT scan or MRI
You will not qualify if you...
- Prior treatment for extensive-stage small cell lung cancer
- Presence of symptomatic brain metastases
- Certain lung diseases, heart diseases, infections, autoimmune diseases, or other cancers
- Peripheral sensory neuropathy
- Other protocol-defined exclusion criteria
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 184 locations
1
Southern Cancer Center, PC
Daphne, Alabama, United States, 36526
Actively Recruiting
2
Local Institution - 0283
Hot Springs, Arkansas, United States, 71913
Completed
3
Florida Cancer Specialists - South
Fort Myers, Florida, United States, 33901
Actively Recruiting
4
Mid Florida Hematology and Oncology Center
Orange City, Florida, United States, 32763
Actively Recruiting
5
Florida Cancer Specialists - North
St. Petersburg, Florida, United States, 33705
Actively Recruiting
6
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital
Marietta, Georgia, United States, 30060
Actively Recruiting
7
Illinois Cancer Care
Peoria, Illinois, United States, 61615
Actively Recruiting
8
Local Institution - 0037
Minneapolis, Minnesota, United States, 55407
Withdrawn
9
University of New Mexico Comprehensive Cancer Center
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
10
Duke Cancer Institute
Durham, North Carolina, United States, 27710
Actively Recruiting
11
Sanford Medical Center
Bismarck, North Dakota, United States, 58501
Actively Recruiting
12
Local Institution - 0010
Fargo, North Dakota, United States, 58102
Not Yet Recruiting
13
Oncology Hematology Care
Cincinnati, Ohio, United States, 45242
Actively Recruiting
14
Sanford Cancer Center
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
15
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
16
Texas Oncology - Central/South Texas
Austin, Texas, United States, 78705
Actively Recruiting
17
Texas Oncology - Northeast Texas
Tyler, Texas, United States, 75702
Actively Recruiting
18
Oncology & Hematology Associates of Southwest Virginia, Inc.
Roanoke, Virginia, United States, 24014
Actively Recruiting
19
Swedish Cancer Institute - Edmonds
Edmonds, Washington, United States, 98026
Actively Recruiting
20
Swedish Medical Center
Seattle, Washington, United States, 98104
Actively Recruiting
21
Local Institution - 0079
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
Completed
22
Local Institution - 0077
ABB, Buenos Aires F.D., Argentina, C1199ABB
Active, Not Recruiting
23
Local Institution - 0100
Buenos Aires, Buenos Aires F.D., Argentina, C1417DTB
Withdrawn
24
Local Institution - 0080
CABA, Buenos Aires F.D., Argentina, C1430EGF
Active, Not Recruiting
25
Local Institution - 0094
Río Cuarto, Córdoba Province, Argentina, X5800AEV
Active, Not Recruiting
26
GenesisCare - Campbelltown
Campbelltown, New South Wales, Australia, 2560
Actively Recruiting
27
Nepean Hospital
Penrith, New South Wales, Australia, 2750
Actively Recruiting
28
Gallipoli Medical Research Ltd
Brisbane, Queensland, Australia, 4120
Actively Recruiting
29
Grampians Health
Ballarat Central, Victoria, Australia, 3350
Actively Recruiting
30
St. John of God Murdoch Hospital
Murdoch, Western Australia, Australia, 6150
Actively Recruiting
31
Medizinische Universität Graz
Graz, Styria, Austria, 8036
Actively Recruiting
32
Klinikum Wels-Grieskirchen GmbH
Wels, Upper Austria, Austria, 4600
Actively Recruiting
33
Kepler Universitätsklinikum
Linz, Austria, 4021
Actively Recruiting
34
Landeskrankenhaus Rankweil
Rankweil, Austria, 6830
Actively Recruiting
35
Cliniques universitaires Saint-Luc
Brussels, Bruxelles-Capitale, Région de, Belgium, 1200
Actively Recruiting
36
UZ Gent
Ghent, Oost-Vlaanderen, Belgium, 9000
Actively Recruiting
37
VITAZ
Sint-Niklaas, Oost-Vlaanderen, Belgium, B-9100
Actively Recruiting
38
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
Liège, Belgium, 4000
Actively Recruiting
39
Hospital São Carlos
Fortaleza, Ceará, Brazil, 60135-237
Actively Recruiting
40
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Actively Recruiting
41
Hospital São Lucas da PUCRS
Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
Actively Recruiting
42
Instituto de Oncologia Saint Gallen
Santa Cruz do Sul, Rio Grande do Sul, Brazil, 96830-180
Actively Recruiting
43
Clínica de Neoplasias Litoral
Itajaí, Santa Catarina, Brazil, 88301-220
Actively Recruiting
44
Fundação Pio XII - Hospital de Câncer de Barretos
Barretos, São Paulo, Brazil, 14784400
Actively Recruiting
45
A. C. Camargo Cancer Center
São Paulo, São Paulo, Brazil, 01509-010
Actively Recruiting
46
Local Institution - 0289
Edmonton, Alberta, Canada, T6G 1Z2
Active, Not Recruiting
47
Local Institution - 0290
Chicoutimi, Quebec, Canada, G7H 5H6
Active, Not Recruiting
48
Local Institution - 0288
Québec, Quebec, Canada, G1V 4G5
Active, Not Recruiting
49
Local Institution - 0287
Rimouski, Quebec, Canada, G5L 5T1
Active, Not Recruiting
50
Local Institution - 0086
Santiago, Santiago Metropolitan, Chile, 0
Active, Not Recruiting
51
Local Institution - 0085
Santiago, Santiago Metropolitan, Chile, 7500921
Active, Not Recruiting
52
Local Institution - 0083
Santiago, Santiago Metropolitan, Chile, 8330032
Active, Not Recruiting
53
Local Institution - 0084
Santiago, Santiago Metropolitan, Chile, 8420383
Active, Not Recruiting
54
Local Institution - 0082
Viña del Mar, Valparaiso, Chile, 2520598
Active, Not Recruiting
55
Beijing Cancer hospital
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
56
Beijing Chest Hospital,Capital Medical University
Beijing, Beijing Municipality, China, 101149
Actively Recruiting
57
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality, China, 400030
Actively Recruiting
58
Fujian Cancer Hospital
Fuzhou, Fujian, China, 350014
Actively Recruiting
59
The First Affiliated hospital of Xiamen University
Xiamen, Fujian, China, 361003
Actively Recruiting
60
Cancer Hospital of Shantou University Medical College
Shantou, Guangdong, China, 515000
Actively Recruiting
61
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang, China, 150081
Actively Recruiting
62
Hubei Cancer Hospital
Wuhan, Hubei, China, 430079
Actively Recruiting
63
Wuhan Tongji Hospital
Wuhan, Hubei, China, 430100
Actively Recruiting
64
Hunan Cancer Hospital
Changsha, Hunan, China, 410013
Actively Recruiting
65
The First Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China, 330006
Actively Recruiting
66
Jilin Province Tumor Hospital
Changchun, Jilin, China, 132000
Actively Recruiting
67
Local Institution - 0235
Shenyang, Liaoning, China, 110042
Not Yet Recruiting
68
Xi'an International Medical Center Hospital
Xi'an, Shaanxi, China, 710126
Actively Recruiting
69
Shandong Cancer Hospital
Jinan, Shandong, China, 250117
Actively Recruiting
70
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
71
Zhongshan Hospital,Fudan University
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
72
Shanghai East Hospital
Shanghai, Shanghai Municipality, China, 200120
Actively Recruiting
73
Sichuan Cancer hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
74
Tianjin Medical University Cancer Institute & Hospital
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
75
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310016
Actively Recruiting
76
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
77
Taizhou Hospital of Zhejiang Province
Linhai, Zhejiang, China, 317000
Actively Recruiting
78
Local Institution - 0114
Brno, Brno-město, Czechia, 656 53
Active, Not Recruiting
79
Local Institution - 0117
Ostrava, Ostrava Město, Czechia, 703 00
Active, Not Recruiting
80
Local Institution - 0113
Prague, Praha 4, Czechia, 14059
Active, Not Recruiting
81
Local Institution - 0116
Olomouc, Czechia, 779 00
Active, Not Recruiting
82
Hôpital Arnaud de Villeneuve - CHU Montpellier
Montpellier, Hérault, France, 34090
Actively Recruiting
83
Chu Grenoble Alpes
La Tronche, Isère, France, 38700
Actively Recruiting
84
CHU Lille - Institut Coeur Poumon
Lille, Nord, France, 59037
Actively Recruiting
85
L Hopital Nord Ouest
Gleizé, Rhône, France, 69400
Actively Recruiting
86
Centre Hospitalier Lyon Sud
Pierre-Bénite, Rhône, France, 69310
Actively Recruiting
87
Centre Hospitalier Intercommunal de Créteil
Créteil, Val-de-Marne, France, 94010
Actively Recruiting
88
Gustave Roussy
Villejuif, Val-de-Marne, France, 94800
Actively Recruiting
89
Assistance Publique Hôpitaux de Marseille - Hôpital Nord
Marseille, France, 13915
Actively Recruiting
90
Institut Curie
Paris, France, 75248
Actively Recruiting
91
Centre Hospitalier de Cornouaille Quimper - Concarneau
Quimper, France, 29000
Actively Recruiting
92
Krankenhaus Nordwest GmbH
Frankfurt am Main, Hesse, Germany, 60488
Actively Recruiting
93
Pius Hospital Oldenburg
Oldenburg, Lower Saxony, Germany, 26121
Actively Recruiting
94
Klinikum Köln-Merheim
Cologne, North Rhine-Westphalia, Germany, 51109
Actively Recruiting
95
Krankenhaus Martha-Maria Halle-Dölau
Halle, Saxony-Anhalt, Germany, 06120
Actively Recruiting
96
Zentralklinik Bad Berka
Bad Berka, Thuringia, Germany, 99437
Actively Recruiting
97
Asklepios Klinik Gauting GmbH
Gauting, Germany, 82131
Actively Recruiting
98
LungenClinic Grosshansdorf
Großhansdorf, Germany, 22927
Actively Recruiting
99
Thoraxklinik-Heidelberg gGmbH
Heidelberg, Germany, 69126
Actively Recruiting
100
Robert Bosch Krankenhaus GmbH
Stuttgart, Germany, 70736
Actively Recruiting
101
Local Institution - 0063
Athens, Attikí, Greece, 115 26
Active, Not Recruiting
102
Local Institution - 0064
Athens, Attikí, Greece, 115 27
Active, Not Recruiting
103
Local Institution - 0062
Thessaloniki, Kentrikí Makedonía, Greece, 540 07
Active, Not Recruiting
104
Local Institution - 0058
Thessaloniki, Thessaloníki, Greece, 570 01
Active, Not Recruiting
105
Local Institution - 0059
Larissa, Thessalía, Greece, 41110
Active, Not Recruiting
106
Local Institution - 0274
Bengaluru, Karnataka, India, 560017
Active, Not Recruiting
107
Local Institution - 0278
New Delhi, National Capital Territory of Delhi, India, 110029
Withdrawn
108
Local Institution - 0271
Madurai, Tamil Nadu, India, 625107
Active, Not Recruiting
109
Mahamana Pandit Madan Mohan Malviya Cancer Centre
Varanasi, Uttar Pradesh, India, 221005
Actively Recruiting
110
Netaji Subhas Chandra Bose Cancer Hospital
Kolkata, West Bengal, India, 700094
Actively Recruiting
111
Local Institution - 0072
Naples, Campania, Italy, 80131
Active, Not Recruiting
112
Local Institution - 0068
Milan, Lombardy, Italy, 20133
Active, Not Recruiting
113
Local Institution - 0069
Rome, Roma, Italy, 00144
Active, Not Recruiting
114
Local Institution - 0110
Perugia, Umbria, Italy, 06132
Active, Not Recruiting
115
Local Institution - 0070
Peschiera del Garda, Verona, Italy, 37019
Active, Not Recruiting
116
Local Institution - 0074
Bologna, Italy, 40138
Active, Not Recruiting
117
Local Institution - 0067
Milan, Italy, 20141
Active, Not Recruiting
118
National Hospital Organization Shikoku Cancer Center
Matsuyama, Ehime, Japan, 791-0280
Actively Recruiting
119
Kurume University Hospital
Kurume, Fukuoka, Japan, 830-0011
Actively Recruiting
120
Hokkaido University Hospital
Sapporo, Hokkaido, Japan, 0608648
Actively Recruiting
121
Kobe City Medical Center General Hospital
Kobe, Hyōgo, Japan, 650-0047
Actively Recruiting
122
Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan, 920-8641
Actively Recruiting
123
Local Institution - 0316
Yokohama, Kanagawa, Japan, 236-0051
Completed
124
Sendai Kousei Hospital
Sendai, Miyagi, Japan, 9810914
Actively Recruiting
125
Local Institution - 0324
Kashihara, Nara, Japan, 634-8522
Completed
126
Kurashiki Central Hospital
Kurashiki, Okayama-ken, Japan, 710-8602
Actively Recruiting
127
Kansai Medical University Hospital
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
128
Kindai University Hospital
Ōsaka-sayama, Osaka, Japan, 589-8511
Actively Recruiting
129
Osaka Medical and Pharmaceutical University Hospital
Takatsuki, Osaka, Japan, 569-8686
Actively Recruiting
130
Saitama Medical University International Medical Center
Hidaka, Saitama, Japan, 350-1298
Actively Recruiting
131
Saitama Prefectural Cancer Center
Ina-machi, Saitama, Japan, 362-0806
Actively Recruiting
132
Hamamatsu University Hospital
Hamamatsu, Shizuoka, Japan, 431-3192
Actively Recruiting
133
Nippon Medical School Hospital
Bunkyo-ku, Tokyo, Japan, 1138603
Actively Recruiting
134
The Cancer Institute Hospital of JFCR
Koto, Tokyo, Japan, 135-8550
Actively Recruiting
135
Fukushima Medical University
Fukushima, Japan, 960-1295
Actively Recruiting
136
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia, 50586
Actively Recruiting
137
University Malaya Medical Centre
Kuala Lumpur, Kuala Lumpur, Malaysia, 50603
Actively Recruiting
138
Sarawak General Hospital
Kuching, Sarawak, Malaysia, 93586
Actively Recruiting
139
Centro Inmuno-Oncología Occidente
Guadalajara, Jalisco, Mexico, 44630
Actively Recruiting
140
Local Institution - 0147
Monterrey, Nuevo León, Mexico, 66460
Not Yet Recruiting
141
Local Institution - 0145
Puebla City, Mexico, 72424
Active, Not Recruiting
142
Amsterdam UMC, locatie VUmc
Amsterdam, North Holland, Netherlands, 1081 HV
Actively Recruiting
143
Ziekenhuis Rijnstate
Arnhem, Netherlands, 6815 AD
Actively Recruiting
144
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ
Actively Recruiting
145
Przychodnia Lekarska KOMED
Konin, Greater Poland Voivodeship, Poland, 62-500
Actively Recruiting
146
Centrum Medyczne Pratia Poznań
Poznan, Greater Poland Voivodeship, Poland, 60-192
Actively Recruiting
147
Szpital Specjalistyczny w Prabutach Spolka z o.o.
Prabuty, Pomeranian Voivodeship, Poland, 82-550
Actively Recruiting
148
Local Institution - 0195
Bydgoszcz, Poland, 85796
Active, Not Recruiting
149
Local Institution - 0189
Lodz, Łódź Voivodeship, Poland, 93-338
Active, Not Recruiting
150
SC Memorial Healthcare International SRL
Bucharest, Bucharest, Romania, 013812
Actively Recruiting
151
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
Bucharest, Bucharest, Romania, 022328
Actively Recruiting
152
SC Radiotherapy Center Cluj SRL
Florești, Cluj, Romania, 407280
Actively Recruiting
153
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Dolj, Romania, 200542
Actively Recruiting
154
Institutul Oncologic Cluj
Cluj-Napoca, Romania, 400015
Actively Recruiting
155
S.C. Centrul de Oncologie Euroclinic S.R.L.
Iași, Romania, 700106
Actively Recruiting
156
Institutul Regional de Oncologie
Iași, Romania, 700483
Actively Recruiting
157
Chungbuk National University Hospital
Cheongju-si, Chungcheongbuk-do [Chungbuk], South Korea, 28644
Actively Recruiting
158
Seoul National University Bundang Hospital
Seongnam, Kyǒnggi-do, South Korea, 13620
Actively Recruiting
159
Ajou University Hospital
Suwon, Kyǒnggi-do, South Korea, 16499
Actively Recruiting
160
Severance Hospital, Yonsei University Health System
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 03722
Actively Recruiting
161
Asan Medical Center
Seoul, Seoul-teukbyeolsi [Seoul], South Korea, 05505
Actively Recruiting
162
Keimyung University Dongsan Hospital
Daegu, Taegu-Kwangyǒkshi, South Korea, 42601
Actively Recruiting
163
CHUS - Hospital Clinico Universitario
Santiago de Compostela, A Coruña [La Coruña], Spain, 15706
Actively Recruiting
164
Hospital Clínic de Barcelona
Barcelona, Catalunya [Cataluña], Spain, 08036
Actively Recruiting
165
Hospital de la Santa Creu i Sant Pau
Barcelona, Catalunya [Cataluña], Spain, 08041
Actively Recruiting
166
Hospital Universitario de Jaen
Jaén, Jaén, Spain, 23007
Actively Recruiting
167
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Comunidad de, Spain, 28034
Actively Recruiting
168
Hospital Universitario 12 de Octubre
Madrid, Madrid, Comunidad de, Spain, 28041
Actively Recruiting
169
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, Madrid, Comunidad de, Spain, 28222
Actively Recruiting
170
Hospital General Universitario de Valencia
Valencia, Valenciana, Comunitat, Spain, 46014
Actively Recruiting
171
Hospital Universitario Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
172
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
173
Kantonsspital Graubünden
Chur, Switzerland, 7000
Actively Recruiting
174
Kantonsspital Winterthur
Winterthur, Switzerland, 8401
Actively Recruiting
175
UniversitätsSpital Zürich
Zurich, Switzerland, 8091
Actively Recruiting
176
T.C. Saglik Bakanligi - Izmir Il Saglik Mudurlugu Cigli Bolge Egitim Hastanesi
Çiğli, İzmir, Turkey (Türkiye), 35620
Actively Recruiting
177
Adana City Hospital
Adana, Turkey (Türkiye), 01370
Actively Recruiting
178
Gulhane Egitim Arastirma Hastanesi
Ankara, Turkey (Türkiye), 06010
Actively Recruiting
179
Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Araştırma Hastanesi
Ankara, Turkey (Türkiye), 06280
Actively Recruiting
180
Istanbul Medeniyet University
Istanbul, Turkey (Türkiye), 34732
Actively Recruiting
181
James Cook University Hospital
Central Middlesbrough, Middlesbrough, United Kingdom, TS4 3BW
Actively Recruiting
182
Aberdeen Royal Infirmary
Aberdeen, United Kingdom, AB9 2ZB
Actively Recruiting
183
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
184
The Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom, CH63 4JY
Actively Recruiting
Research Team
B
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
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First line of the email MUST contain NCT # and Site #.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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