A Multi-Centered Phase 1 Trial to Evaluate the Memory Responses to a Single Boosting Vaccination With ALVAC-HIV vCP205 in Volunteers Who Have Previously Received Poxvirus-Based Vaccines

Inclusion Criteria

You may be eligible for this study if you:

• Are 18-60 years old.
• Are willing to use adequate birth control for 1 month before study entry and during the study.
• Have a CD4 count of at least 400 cells/mm3.
• Have a normal medical history and physical examination.
• Are available for 3 months of follow-up.
• Have participated in AVEG Protocol 014C or 022A and received all the scheduled vaccinations 24 or more months before this study, or have never participated in HIV-vaccine studies.
• Are HIV-negative within 8 weeks of study entry.
• Are negative for hepatitis B surface antigen.

Exclusion Criteria

You will not be eligible for this study if you:

• Are pregnant or breast-feeding.
• Have a history of an immune system problem, any long-term illness, or any autoimmune disease.
• Have a history of using medications which affect your immune system.
• Have a history of cancer, except if it has been removed with surgery and cure is most likely.
• Have a medical or mental condition which interferes with the study.
• Have a job or work which interferes with the study.
• Have ever attempted suicide, thought of attempting suicide, or have a severe mental condition.
• Have received vaccines within 60 days of study entry.
• Have used experimental drugs within 30 days prior to study entry.
• Have received any blood products, such as immunoglobulin, in the last 6 months.
• Have active syphilis.
• Have active tuberculosis.
• Have any history of severe allergic reactions, including reactions to vaccines.
• Have an allergy to egg products or neomycin.

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety