Actively Recruiting
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Led by Genentech, Inc. · Updated on 2026-05-04
224
Participants Needed
82
Research Sites
161 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
CONDITIONS
Official Title
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of ulcerative colitis established at least 3 months prior
- Moderately to severely active ulcerative colitis assessed by mMS
- Inadequate response, loss of response, or intolerance to conventional or advanced therapies for ulcerative colitis
You will not qualify if you...
- Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for ulcerative colitis
- Diagnosis of Crohn's disease or indeterminate colitis
- Treatment with an advanced therapy targeting tumor necrosis factor-like cytokine 1A (TL1a)
- Inadequate response, loss of response, or intolerance to treatment with an advanced therapy targeting IL-12 and/or IL-23
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 82 locations
1
Gastro Care Institute
Lancaster, California, United States, 93534
Actively Recruiting
2
Medical Associates Research Group, Inc.
San Diego, California, United States, 92123
Actively Recruiting
3
Peak Gastroenterology Associates
Colorado Springs, Colorado, United States, 80907
Actively Recruiting
4
Clinical Research of Osceola, LLC
Kissimmee, Florida, United States, 34741
Actively Recruiting
5
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
6
Intercity Gastroenterology
Fresh Meadows, New York, United States, 11366
Actively Recruiting
7
Monroe Biomedical Research
Monroe, North Carolina, United States, 28112
Actively Recruiting
8
Mater Misericordiae Ltd
South Brisbane, Queensland, Australia, 4101
Actively Recruiting
9
Chronos Pesquisa Clinica
Brasília, Federal District, Brazil, 72145-450
Actively Recruiting
10
Hospital Felicio Rocho
Belo Horizonte, Minas Gerais, Brazil, 30110-934
Actively Recruiting
11
Associao Paranaense de Cultura APC
Curitiba, Paraná, Brazil, 80230-130
Actively Recruiting
12
Centro Digestivo de Curitiba
Curitiba, Paraná, Brazil, 80430-160
Actively Recruiting
13
Hospital de Clnicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
Actively Recruiting
14
Hospital Ernesto Dornelles
Porto Alegre, Rio Grande do Sul, Brazil, 90160-093
Actively Recruiting
15
Newdata Clinical Trials
Aracaju, Sergipe, Brazil, 49075-000
Actively Recruiting
16
Pesquisare Saude
Santo André, São Paulo, Brazil, 09080-110
Actively Recruiting
17
CPQuali Pesquisa Clinica Ltda
So Paulo, São Paulo, Brazil, 01228-000
Actively Recruiting
18
London Digestive Disease Institute
London, Ontario, Canada, N6K 1M6
Actively Recruiting
19
Hopital Maisonneuve-Rosemont d/b/a CIUSSS de l'Est-de-l'le-de-Montral
Montreal, Quebec, Canada, H1T 2M4
Actively Recruiting
20
Clinique IMD
Montreal, Quebec, Canada, H3H 1E8
Actively Recruiting
21
Zhongshan Hospital Xiamen University
Xiamen, Fujian, China, 361004
Actively Recruiting
22
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450014
Actively Recruiting
23
Binzhou Medical university hospital
Binzhou, Shandong, China, 256603
Actively Recruiting
24
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Actively Recruiting
25
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang, China, 315010
Actively Recruiting
26
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Hangzhou, China, 310018
Actively Recruiting
27
PreventaMed, s.r.o.
Olomouc, Czechia, 779 00
Actively Recruiting
28
Nemocnice Slany
Slaný, Czechia, 27401
Actively Recruiting
29
Groupe Hospitalier Ambroise Pare - Institut des MICI
Neuilly, Hauts De Seine, France, 92200
Actively Recruiting
30
CHU Saint Etienne - Hpital Nord
Saint-Étienne-de-Montluc, Pays de la Loire Region, France, 42055
Actively Recruiting
31
CHU Clermont Ferrand - Hôpital d'Estaing
Clermont-Ferrand, Puy De Dome, France, 63000
Actively Recruiting
32
Centre hospitalier Lyon Sud
Pierre-Bénite, Rhone, France, 69495
Actively Recruiting
33
Universitaetsklinikum Frankfurt Goethe-Universitaet
Frankfurt am Main, Hesse, Germany, 60590
Actively Recruiting
34
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rome, Emilia-Romagna, Italy, 00168
Actively Recruiting
35
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Lombardy, Italy, 25124
Actively Recruiting
36
ASST Rhodense, Rho Memorial Hospital
Rho, Lombardy, Italy, 20017
Actively Recruiting
37
Istituto Clinico Humanitas
Rozzano, Lombardy, Italy, 20089
Actively Recruiting
38
I.R.C.C.S Policlinico San Donato
San Donato Milanese (MI), Lombardy, Italy, 20097
Actively Recruiting
39
Ospedale Mauriziano Umberto I
Turin, Piedmont, Italy, 10128
Actively Recruiting
40
Kokikai Tsujinaka Hospital Kashiwanoha
Kashiwa-shi, Chiba, Japan, 277-0871
Actively Recruiting
41
Fukuoka University Hospital
Fukuoka, Fukuoka, Japan, 814-0180
Actively Recruiting
42
NHO Fukuyama Medical Center
Fukuyama-shi, Hiroshima, Japan, 720-8520
Actively Recruiting
43
NHO Kanazawa Medical Center
Kanazawa, Ishikawa-ken, Japan, 920-8650
Actively Recruiting
44
Takamatsu Red Cross Hospital
Takamatsu, Kagawa-ken, Japan, 760-0017
Actively Recruiting
45
NHO Osaka National Hospital
Osaka, Osaka, Japan, 540-0006
Actively Recruiting
46
Saga University Hospital
Saga, Saga-ken, Japan, 849-8501
Actively Recruiting
47
Shinseikai Sai Gastroenterology, Proctology
Fujidera-shi, Japan, 583-0027
Actively Recruiting
48
Kojunkai Daido Clinic
Nagoya, Japan, 457-8511
Actively Recruiting
49
Centro Medico Clinico Quirurgico Especializado en Investigacion
Tlajomulco de Zúñiga, Jalisco, Mexico, 45645
Actively Recruiting
50
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan
Mérida, Yucatán, Mexico, 97130
Actively Recruiting
51
Centrum Medyczne "Medis"
Bydgoszcz, Poland, 85-229
Actively Recruiting
52
Clinsante S.C. Osrodek Badan Klinicznych
Bydgoszcz, Poland, 85-794
Actively Recruiting
53
Centrum Medyczne Lukamed Joanna Luka
Chojnice, Poland, 89-600
Actively Recruiting
54
Vita Longa Sp. z o.o.
Katowice, Poland, 40-748
Actively Recruiting
55
MZ Badania Slowik Zymla Sp.j.
Knurów, Poland, 44-190
Actively Recruiting
56
Allmedica Badania Kliniczne sp. z o.o. sp.k.
Nowy Targ, Poland, 34-400
Actively Recruiting
57
SOLUMED Centrum Medyczne
Poznan, Poland, 60-529
Actively Recruiting
58
NSZOZ Termedica Centrum Badan Klinicznych
Poznan, Poland, 60-681
Actively Recruiting
59
Clinical Research Center Spka z ograniczon odpowiedzialnoci Medic-R Sp.k.
Poznan, Poland, 61-731
Actively Recruiting
60
Velocity Skierniewice Sp. z o.o
Skierniewice, Poland, 96-100
Actively Recruiting
61
Twoja Przychodnia-Szczecinskie Centrum Medyczne
Szczecin, Poland, 71-434
Actively Recruiting
62
Centrum Zdrowia MDM
Warsaw, Poland, 00-189
Actively Recruiting
63
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych Administracji
Warsaw, Poland, 02-507
Actively Recruiting
64
Provita Poliklinika sp. z o.o
Warsaw, Poland, 02-647
Actively Recruiting
65
Medon Clinical Research sp. z o.o
Warsaw, Poland, 02-679
Actively Recruiting
66
Medical Network Spka z o. o., WIP Warsaw IBD Point Profesor Kierkus
Warsaw, Poland, 04-501
Actively Recruiting
67
Przychodnia VISTAMED
Wroc?aw, Poland, 53-149
Actively Recruiting
68
ETG Zamosc
Zamość, Poland, 22-400
Actively Recruiting
69
Yonsei University Wonju Severance Christian Hospital
Wŏnju, Gangwon-do, South Korea, 26426
Actively Recruiting
70
Inje university Haeundae Paik Hospital
Busan, South Korea, 48108
Actively Recruiting
71
The Catholic University of Korea Daejeon ST. Mary?s Hospital
Daejeon, South Korea, 34943
Actively Recruiting
72
Chosun University Hospital
Gwangju, South Korea, 61453
Actively Recruiting
73
Kangbuk Samsung Hospital
Seoul, South Korea, 03181
Actively Recruiting
74
The Catholic University of Korea Eunpyeong St. Mary's Hospital
Seoul, South Korea, 03312
Actively Recruiting
75
Asan Medical Center.
Seoul, South Korea, 05505
Actively Recruiting
76
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
77
Chung-Ang University Hospital
Seoul, South Korea, 06973
Actively Recruiting
78
Guy's Hospital
London, Greater London, United Kingdom, SE1 9RT
Actively Recruiting
79
King's College Hospital
London, Greater London, United Kingdom, SE5 9RS
Actively Recruiting
80
Royal Liverpool University Hospital
Liverpool, Merseyside, United Kingdom, L7 8YE
Actively Recruiting
81
John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom, OX3 9DU
Actively Recruiting
82
Addenbrook'es Hospital
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
Research Team
R
Reference Study ID Number: GA45977 https://forpatients.roche.com/
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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