A Phase I Safety and Immunogenicity Trial of Orally Administered Live Attenuated Recombinant Salmonella Typhi CVD 908 Delta-asd (pW57-asd+) Expressing HIV-1 LAI gp120 (VVG 203) and Parenterally Administered HIV-1 MN rgp120 in Alum in HIV-1-Uninfected Volunteers

Inclusion Criteria

You may be eligible for this study if you:

• Are 18-50 years old.
• Are HIV-negative.
• Are healthy and have a normal history and physical exam.
• Agree to practice abstinence or use of effective birth control for 1 month before and during the study.

Exclusion Criteria

You will not be eligible for this study if you:

• Have a history of immune deficiency, chronic illness, or autoimmune disease.
• Have received immunosuppressive medications, blood products, trial drugs, immunoglobulins, or an HIV or typhoid vaccine.
• Have a history of severe allergic reactions.
• Have had prior suicidal attempts or have a psychiatric condition or job commitments which would prevent you from completing the study.
• Have a history of cancer (unless the cancer has been successfully cured), gallbladder disease, typhoid fever, migraines or other severe headaches, cardiac valve defects, or congenital heart disease.
• Have active syphilis or tuberculosis.
• Are allergic to certain medications.
• Are pregnant or breast-feeding.
• Have household contact with infants or persons who are pregnant, immunodeficient, or HIV-positive.
• Are unavailable for 12 months of follow-up.
• Have hepatitis B.
• Have a history of injection drug use within 12 months of enrollment or have higher or intermediate risk sexual behavior.

History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety