Observational Study of Genetic Factors and Outcomes in Alcoholic Liver Disease Including Severe and Non-Severe Alcoholic Hepatitis

What this Trial Is About

Researchers are investigating alcoholic hepatitis, a serious liver condition with a high short-term risk of death, especially in severe cases. This observational study aims to determine how common alcoholic hepatitis is among patients admitted with jaundice and to understand outcomes based on disease severity. The study also plans to assess survival rates, liver dysfunction markers, and to create a biobank with genetic samples to explore inflammatory and regenerative profiles. Additionally, it will evaluate non-invasive diagnostic methods for this condition. Participants will be grouped into those with alcoholic liver disease without hepatitis, those with severe alcoholic hepatitis Maddrey score 32 or higher, and those with non-severe alcoholic hepatitis Maddrey score below 32. The study involves collecting biological samples such as blood, serum, and plasma at different times, including baseline and various follow-up points up to 12 months, to analyze genetic and biochemical profiles and liver function changes. During the study, participants will undergo liver biopsy at baseline to confirm diagnosis. Follow-up assessments of liver function, including serum bilirubin, creatinine, and MELD score, will be conducted at 7 days, 30 days, 3 months, 6 months, and 12 months. Survival will be monitored for up to one year. The study will also measure diagnostic accuracy and collect data to better understand disease profiles and outcomes over time.

Study of Genetic Determinants in Alcoholic Hepatitis and Establishment of a Multicenter Prospective Cohort of Patients With Alcoholic Liver Disease