Actively Recruiting

Phase 2
Age: 18Years - 79Years
All Genders
NCT06991257

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Led by Pfizer · Updated on 2026-05-12

620

Participants Needed

139

Research Sites

129 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

CONDITIONS

Official Title

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Who Can Participate

Age: 18Years - 79Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Aged 18 years to less than 80 years
  • Clinically confirmed diagnosis of heart failure for at least 3 months
  • New York Heart Association Class II-IV symptoms
  • Left ventricular ejection fraction greater than 40%
  • Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score less than 85
  • Six-minute walking distance greater than 75 meters
Not Eligible

You will not qualify if you...

  • Type 1 diabetes mellitus or liver cirrhosis
  • Any condition affecting absorption of the study medicine
  • Major surgery planned during the study that affects walking ability
  • History of heart transplantation or current listing for a heart transplant
  • Current planned use of intravenous vasodilators or inotropes
  • Prior intolerance or known hypersensitivity to an SGLT2 inhibitor or contraindication to its use

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 139 locations

1

National Heart Institute

Beverly Hills, California, United States, 90211

Actively Recruiting

2

Orange County Research Center

Lake Forest, California, United States, 92630

Actively Recruiting

3

Comprehensive Cardiovascular Care

Santa Maria, California, United States, 93454

Actively Recruiting

4

FOMAT Medical Research

Santa Maria, California, United States, 93454

Actively Recruiting

5

FWD Clinical Research

Boca Raton, Florida, United States, 33486

Active, Not Recruiting

6

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States, 32216

Actively Recruiting

7

Infinite Clinical Research

Miami, Florida, United States, 33133

Actively Recruiting

8

Flourish Research Acquisition, LLC dba Flourish Research - North Miami

Miami, Florida, United States, 33138

Actively Recruiting

9

Amavita Research Services

North Miami Beach, Florida, United States, 33169

Actively Recruiting

10

Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, United States, 32789

Actively Recruiting

11

NMH Clinical Research Unit

Chicago, Illinois, United States, 60611

Actively Recruiting

12

Northwestern Memorial HealthCare - Arkes Pavilion

Chicago, Illinois, United States, 60611

Actively Recruiting

13

Northwestern Memorial HealthCare - Feinberg Pavilion

Chicago, Illinois, United States, 60611

Actively Recruiting

14

Northwestern Memorial HealthCare - Galter Pavilion

Chicago, Illinois, United States, 60611

Actively Recruiting

15

Northwestern Memorial Hospital Investigational Drug Service (IDS)

Chicago, Illinois, United States, 60611

Actively Recruiting

16

Northwestern University

Evanston, Illinois, United States, 60208

Actively Recruiting

17

Chicago Medical Research

Hazel Crest, Illinois, United States, 60429

Actively Recruiting

18

NexGen Research

Fort Wayne, Indiana, United States, 46804

Actively Recruiting

19

Reid Physician Associates

Richmond, Indiana, United States, 47374

Actively Recruiting

20

Ascension Saint Agnes Heart Care

Baltimore, Maryland, United States, 21229

Actively Recruiting

21

Chesapeake Cardiac Care

Bowie, Maryland, United States, 20715

Not Yet Recruiting

22

Flourish Research - Bowie

Bowie, Maryland, United States, 20715

Not Yet Recruiting

23

Velocity Clinical Research, Lincoln, Pioneer Heart Institute

Lincoln, Nebraska, United States, 68510

Actively Recruiting

24

NexGen Research

Lima, Ohio, United States, 45801

Actively Recruiting

25

Headlands Horizons, LLC dba Headlands Research-Brownsville

Brownsville, Texas, United States, 78526

Actively Recruiting

26

Valley Regional Medical Center

Brownsville, Texas, United States, 78526

Actively Recruiting

27

North Dallas Research Associates

McKinney, Texas, United States, 75069

Actively Recruiting

28

Northwest Houston Heart Center

Tomball, Texas, United States, 77375

Actively Recruiting

29

L2IP - Instituto de Pesquisas Clínicas

Brasília, Federal District, Brazil, 70.200-730

Actively Recruiting

30

L2IP - Instituto de Pesquisas Clínicas

Brasília, Federal District, Brazil, 70200730

Actively Recruiting

31

Cardresearch - Cardiologia Assistencial e Pesquisa

Belo Horizonte, Minas Gerais, Brazil, 30150-274

Not Yet Recruiting

32

Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, Brazil, 90430-001

Not Yet Recruiting

33

CoraCentro Pesquisa Clinica

Porto Alegre, Rio Grande do Sul, Brazil, 90840-440

Actively Recruiting

34

Instituto de Pesquisa clinica de Campinas

Campinas, São Paulo, Brazil, 13060-080

Actively Recruiting

35

Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping

Ribeirão Preto, São Paulo, Brazil, 14026-900

Actively Recruiting

36

Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, São Paulo, Brazil, 15090000

Not Yet Recruiting

37

UNESP - Faculdade de Medicina da Universidade Estadual Paulista

Botucatu, SÃO PAUL, Brazil, 18618-970

Actively Recruiting

38

CEPIC - Centro Paulista de Investigação Clínica

São Paulo, Brazil, 04266-010

Not Yet Recruiting

39

Incor - Instituto do Coracao

São Paulo, Brazil, 05403-000

Actively Recruiting

40

Diagnostic Consultative Center - 1 Lom EOOD

Lom, Montana, Bulgaria, 3600

Actively Recruiting

41

Diagnostic Consultative Center "Ascendent"

Sofia, Sofia (stolitsa), Bulgaria, 1202

Actively Recruiting

42

Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD

Sofia, Sofia (stolitsa), Bulgaria, 1233

Actively Recruiting

43

Diagnostic Consultative Center Aleksandrovska

Sofia, Sofia (stolitsa), Bulgaria, 1431

Actively Recruiting

44

University Multiprofile Hospital for Active Treatment Sveta Ekaterina EAD

Sofia, Sofia (stolitsa), Bulgaria, 1431

Actively Recruiting

45

"Multiprofile Hospital for Active Treatment Puls" AD

Blagoevgrad, Bulgaria, 2700

Actively Recruiting

46

Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD

Gabrovo, Bulgaria, 5300

Actively Recruiting

47

Medical Center Hera - Kyustendil EOOD

Kyustendil, Bulgaria, 2500

Actively Recruiting

48

MHAT - Heart and Brain

Pleven, Bulgaria, 5804

Active, Not Recruiting

49

University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD

Plovdiv, Bulgaria, 4002

Actively Recruiting

50

MHAT Hadzhi Dimitar

Sliven, Bulgaria, 8800

Actively Recruiting

51

Аcibadem City Clinic University MHAT EOOD - Third Clinical Base

Sofia, Bulgaria, 1415

Actively Recruiting

52

Medical Center Hera EOOD

Sofia, Bulgaria, 1510

Actively Recruiting

53

Richmond Clinical Trials

Richmond, British Columbia, Canada, V6V 2L1

Actively Recruiting

54

QEII Health Sciences Centre - Victoria General Site

Halifax, Nova Scotia, Canada, B3H 3A7

Actively Recruiting

55

Health Sciences North Research Institute

Greater Sudbury, Ontario, Canada, P3E 5J1

Actively Recruiting

56

ACV Clinic

Greater Sudbury, Ontario, Canada, P3E 5M4

Actively Recruiting

57

CardioQuest Research Centre

Sarnia, Ontario, Canada, N7T 4P5

Actively Recruiting

58

Corcare

Toronto, Ontario, Canada, M1B 5N1

Not Yet Recruiting

59

Community Care Building

Winchester, Ontario, Canada, K0C 2K0

Actively Recruiting

60

Winchester District Memorial Hospital

Winchester, Ontario, Canada, K0C 2K0

Actively Recruiting

61

CIUSSS- saguenay-Lac-Saint-Jean

Chicoutimi, Quebec, Canada, G7H 5H6

Actively Recruiting

62

CHU de Quebec - Université Laval - Hotel Dieu de Quebec

Québec, Quebec, Canada, G1R 2J6

Actively Recruiting

63

Clinique de Médecins Spécialistes

Shebrooke, Quebec, Canada, J1E 0N8

Actively Recruiting

64

Diex Recherche Sherbrooke Est

Sherbrooke, Quebec, Canada, J1E 0N8

Actively Recruiting

65

Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur.

Terrebonne, Quebec, Canada, J6V 2H2

Actively Recruiting

66

Diex Recherche Trois-Rivieres

Trois-Rivières, Quebec, Canada, G9A 4P3

Actively Recruiting

67

Peking University First Hospital

Beijing, Beijing Municipality, China, 100034

Actively Recruiting

68

Lanzhou university second hospital

Lanzhou, Gansu, China, 730030

Not Yet Recruiting

69

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China, 510080

Actively Recruiting

70

Hainan General Hospital

Haikou, Hainan, China, 570311

Actively Recruiting

71

The Second Xiangya Hospital of Central South University

Changsha, Hunan, China, 410011

Actively Recruiting

72

Shaanxi provincial people's hospital

Xi'an, Shaanxi, China, 710068

Not Yet Recruiting

73

Jinan Central Hospital

Jinan, Shandong, China, 250013

Actively Recruiting

74

Shanghai Tongji Hospital

Shanghai, Shanghai Municipality, China, 200065

Actively Recruiting

75

Tianjin People' s Hospital

Tianjin, Tianjin Municipality, China, 300121

Actively Recruiting

76

The First Affiliated Hospital of University of South China

Hengyang, China

Actively Recruiting

77

Sdružené Zdravotnické Zařízení Krnov

Krnov, Moravian-Silesian Region, Czechia, 794 01

Actively Recruiting

78

Kardiologicka ambulance Brno s.r.o.

Brno-Královo Pole, Czechia, 612 00

Actively Recruiting

79

EFERTUS healthcare s.r.o.

Brno-Židenice, Czechia, 615 00

Actively Recruiting

80

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia, 500 05

Actively Recruiting

81

EDUMED s.r.o.

Jaroměř, Czechia, 551 01

Actively Recruiting

82

VASOMED Clinic s.r.o.

Ostrava, Czechia, 710 00

Actively Recruiting

83

AGEL Stredomoravska nemocnicni, a.s., Nemocnice AGEL Prerov

Přerov, Czechia, 751 52

Actively Recruiting

84

Hôpital Arnaud de Villeneuve - CHU Montpellier

Montpellier, Hérault, France, 34090

Not Yet Recruiting

85

Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

Saint-Herblain, Loire-atlantique, France, 44800

Actively Recruiting

86

Centre Hospitalier intercommunal de Toulon La Seyne sur Mer

Toulon, Provence-Alpes-Côte d'Azur Region, France, 83100

Actively Recruiting

87

Chu Grenoble Alpes

Grenoble, France, 38700

Actively Recruiting

88

Da Vinci Magánklinika

Pécs, Baranya, Hungary, 7635

Actively Recruiting

89

CMed Rehabilitacios es Diagnosztikai Kozpont

Székesfehérvár, Fejér, Hungary, 8000

Actively Recruiting

90

BKS Research Kft

Hatvan, Heves County, Hungary, 3000

Actively Recruiting

91

Ezüstfény Klinika Kft

Budapest, Hungary, 1106

Actively Recruiting

92

Semmelweis Egyetem

Budapest, Hungary, 1122

Actively Recruiting

93

Eszak-Pesti Centrumkorhaz-Honvedkorhaz

Budapest, Hungary, 1134

Actively Recruiting

94

Jahn Ferenc Dél-pesti Hospital

Budapest, Hungary, 1204

Actively Recruiting

95

New Medical Center Kft.

Sopron, Hungary, H-9400

Actively Recruiting

96

Kasugai Municipal Hospital

Kasugai, Aichi-ken, Japan, 486-8510

Actively Recruiting

97

Nagoya Tokushukai General Hospital

Kasugai, Aichi-ken, Japan, 487-0016

Actively Recruiting

98

Seikeikai New Tokyo Heart Clinic

Matsudo, Chiba, Japan, 271-0077

Actively Recruiting

99

Toho University Sakura Medical Center

Sakura, Chiba, Japan, 285-8741

Actively Recruiting

100

Teine Keijinkai Hospital

Sapporo, Hokkaido, Japan, 006-8555

Actively Recruiting

101

Koga General Hospital

Koga, Ibaraki, Japan, 306-0041

Actively Recruiting

102

Sagamihara Kyodo Hospital

Sagamihara, Kanagawa, Japan, 252-5188

Actively Recruiting

103

Yokohama Municipal Citizen's Hospital

Yokohama, Kanagawa, Japan, 221-0855

Actively Recruiting

104

National Hospital Organization Yokohama Medical Center

Yokohama, Kanagawa, Japan, 245-8575

Actively Recruiting

105

National Hospital Organization Mie Chuo Medical Center

Tsu, Mie-ken, Japan, 514-1101

Actively Recruiting

106

National Hospital Organization Sendai Medical Center

Sendai, Miyagi, Japan, 983-8520

Actively Recruiting

107

Kishiwada Tokushukai Hospital

Kishiwada, Osaka, Japan, 596-0042

Actively Recruiting

108

National Hospital Organization Saitama Hospital

Wako, Saitama, Japan, 351-0102

Actively Recruiting

109

Tokyo Metropolitan Toshima Hospital

Itabashi-ku, Tokyo, Japan, 173-0015

Actively Recruiting

110

Showa General Hospital

Kodaira-shi, Tokyo, Japan, 187-8510

Actively Recruiting

111

National Hospital Organization Tokyo Medical Center

Meguro-Ku, Tokyo, Japan, 152-8902

Actively Recruiting

112

NewHeart Watanabe Institute

Suginami, Tokyo, Japan, 168-0065

Actively Recruiting

113

Sekino Hospital

Toshimaku, Tokyo, Japan, 171-0014

Actively Recruiting

114

National Hospital Organization Iwakuni Clinical Center

Iwakuni, Yamaguchi, Japan, 740-8510

Actively Recruiting

115

Nagasaki Harbor Medical Center

Nagasaki, Japan, 850-8555

Actively Recruiting

116

Uniwersytecki Szpital Kliniczny w Poznaniu

Poznan, Greater Poland Voivodeship, Poland, 61-848

Actively Recruiting

117

NZOZ Centrum Medyczne KERmed

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-231

Actively Recruiting

118

Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu

Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100

Actively Recruiting

119

SP ZOZ w Puławach

Puławy, Lublin Voivodeship, Poland, 24-100

Actively Recruiting

120

NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus

Sopot, Pomeranian Voivodeship, Poland, 81-717

Actively Recruiting

121

Kardio Brynow

Katowice, Silesian Voivodeship, Poland, 40-555

Actively Recruiting

122

Research and Cardiovascular Corp.

Ponce, Puerto Rico, 00717

Not Yet Recruiting

123

CHUS - Hospital Clinico Universitario

Santiago de Compostela, A Coruña [LA Coruña], Spain, 15706

Not Yet Recruiting

124

Parc de Salut Mar - Hospital del Mar

Barcelona, Barcelona [barcelona], Spain, 08003

Actively Recruiting

125

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [barcelona], Spain, 08035

Actively Recruiting

126

Hospital de la Santa Creu i Sant Pau

Barcelona, Catalunya [cataluña], Spain, 08041

Actively Recruiting

127

Hospital Universitari de Bellvitge

L'Hospitalet de Llobregat, Catalunya [cataluña], Spain, 08907

Not Yet Recruiting

128

Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, Spain, 28220

Actively Recruiting

129

Hospital Universitario Ramón y Cajal

Madrid, Madrid, Comunidad de, Spain, 28034

Actively Recruiting

130

Hospital Universitario La Paz

Madrid, Madrid, Comunidad de, Spain, 28046

Actively Recruiting

131

Hospital Clinico de Valencia

Valencia, Valenciana, Comunitat, Spain, 46010

Actively Recruiting

132

Hospital General Universitario de Valencia

Valencia, Spain, 46014

Not Yet Recruiting

133

Hospital Universitari i Politecnic La Fe

Valencia, Spain, 46026

Actively Recruiting

134

Ninewells Hospital and Medical School

Dundee, Dundee CITY, United Kingdom, DD1 9SY

Actively Recruiting

135

St. George's Hospital

London, England, United Kingdom, SW17 0QT

Actively Recruiting

136

Norfolk and Norwich University Hospitals NHS Foundation Trust

Norwich, Norfolk, United Kingdom, NR4 7UY

Actively Recruiting

137

St Richard's Hospital

Chichester, WEST Sussex, United Kingdom, PO19 6SE

Actively Recruiting

138

South Eastern Health and Social Care Trust

Belfast, United Kingdom, BT16 1RH

Actively Recruiting

139

Wycombe General Hospital

High Wycombe, United Kingdom, HP11 2TT

Actively Recruiting

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Research Team

P

Pfizer CT.gov Call Center

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

4

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A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF) | DecenTrialz