Nutrition and Exercise to Optimize Muscle and Adiposity in Adults With Philadelphia Chromosome Negative B-ALL During Hospitalized Induction Therapy

What this Trial Is About

Researchers are evaluating how nutrition and exercise affect muscle and body fat in adults with Philadelphia Chromosome Negative B-Cell Acute Lymphoblastic Leukemia (B-ALL) who are undergoing intensive inpatient induction chemotherapy. The trial aims to study these interventions during hospital treatment to understand their feasibility and impact on body composition and treatment outcomes. Participants will receive two main interventions: a nutrition intervention and a physical exercise intervention. The nutrition plan focuses on a 10% calorie reduction based on each patient’s metabolic rate, using a high-protein, low-fat, and high-fiber diet. A dietician will guide patients on dietary choices and monitor adherence every two days, excluding weekends. The exercise intervention targets 200 minutes of moderate aerobic and resistance activity weekly, customized by a physical therapist who evaluates patients every 48 hours, excluding weekends. All participants will wear a Fitbit® to track activity levels. During the study, patients will be monitored for adherence to the diet and exercise plans, changes in body fat and muscle mass, minimal residual disease, treatment side effects, and metabolic changes. The trial lasts approximately 22 days during the induction treatment phase. Researchers will assess the feasibility of these interventions over about one year of recruitment. Safety and progress will be closely observed throughout the study period.

Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)