Actively Recruiting
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Led by Janssen Research & Development, LLC · Updated on 2026-05-11
800
Participants Needed
117
Research Sites
187 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out whether treatment with pasritamig and docetaxel prolongs radiographic progression free survival (rPFS) (the length of time from start of treatment until disease worsens as determined by scans) when compared to treatment with docetaxel in participants with metastatic castrate-resistant prostate cancer (mCRPC; a cancer of prostate, a male reproductive gland found below the bladder, that grows despite low levels of male hormones).
CONDITIONS
Official Title
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have histologically confirmed adenocarcinoma of the prostate
- Have disease that is metastatic at the time of the screening as determined by the investigator
- Participants must receive ongoing androgen deprivation therapy with a gonadotropin releasing hormone analog throughout the treatment or have had prior bilateral orchiectomy, and have serum testosterone less than or equal to 50 nanogram per milliliter (<= 1.73 nanomoles per Liter) at screening
- Have progressed on at least 1 novel androgen receptor pathway inhibition but received no more than 2 different ARPI for any stage of disease
- Must have discontinued ARPI before randomization into the study
- Have an eastern cooperative oncology group performance status of 0 to 1
You will not qualify if you...
- Known history of either brain or leptomeningeal prostate cancer metastases
- Participants with known breast cancer gene 1/2 mutations who have not received treatment with a poly (ADP-ribose) polymerase inhibitor, unless not available or contraindicated
- Prior or concurrent second malignancy (other than the disease under study) because the natural history or treatment could interfere with study endpoints
- Received cytotoxic chemotherapy for prostate cancer in any setting
- Received prior treatment with human kallikrein 2 directed therapies
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 117 locations
1
Arizona Clinical Trials
Chandler, Arizona, United States, 85225
Actively Recruiting
2
Arkansas Urology
Little Rock, Arkansas, United States, 72211
Actively Recruiting
3
University Of California San Diego
La Jolla, California, United States, 92037
Actively Recruiting
4
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States, 90033
Actively Recruiting
5
Valkyrie Clinical Trials
Los Angeles, California, United States, 90067
Actively Recruiting
6
Kaiser Permanente Southern California
Riverside, California, United States, 92505
Actively Recruiting
7
Sharp Center for Research
San Diego, California, United States, 92123
Actively Recruiting
8
Providence Saint John s Health Center
Santa Monica, California, United States, 90404
Actively Recruiting
9
Rocky Mountain Cancer Centers
Aurora, Colorado, United States, 80012
Actively Recruiting
10
Grand Valley Oncology
Grand Junction, Colorado, United States, 81505
Actively Recruiting
11
Colorado Clinical Research
Lakewood, Colorado, United States, 80228
Actively Recruiting
12
Florida Cancer Specialists
Sarasota, Florida, United States, 34232
Actively Recruiting
13
Winship Cancer Institute Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
14
Duly Health and Care
Lisle, Illinois, United States, 60532
Actively Recruiting
15
Cancer Center of Kansas Heritage Plaza Medical Building
Wichita, Kansas, United States, 67214
Actively Recruiting
16
East Jefferson General Hospital
Metairie, Louisiana, United States, 70006
Actively Recruiting
17
University of Maryland
Baltimore, Maryland, United States, 21201
Actively Recruiting
18
Profound Research LLC at Cancer and Leukemia Center
Sterling Heights, Michigan, United States, 48314
Actively Recruiting
19
HealthPartners Frauenshuh Cancer Center CRC West
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
20
HealthPartners Cancer Center at Regions Hospital CRC East
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
21
NHO Revive Research Institute, LLC
Lincoln, Nebraska, United States, 68506
Actively Recruiting
22
Astera Cancer Care
East Brunswick, New Jersey, United States, 08816
Actively Recruiting
23
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08901
Actively Recruiting
24
Oregon Urology Institute
Springfield, Oregon, United States, 97477
Actively Recruiting
25
Lehigh Valley Hospital
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
26
MidLantic Urology
Bala-Cynwyd, Pennsylvania, United States, 19004
Actively Recruiting
27
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
28
University Of Pittsburgh Medical Center UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
29
Carolina Urologic Research Center
Myrtle Beach, South Carolina, United States, 29572
Actively Recruiting
30
Avera Medical Group
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
31
Tennessee Cancer Specialists
Knoxville, Tennessee, United States, 37909
Actively Recruiting
32
Texas Oncology
Austin, Texas, United States, 78731
Actively Recruiting
33
Houston Metro Urology
Houston, Texas, United States, 77027
Actively Recruiting
34
Texas Oncology 1
Sugar Land, Texas, United States, 77479
Actively Recruiting
35
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22031
Actively Recruiting
36
Fred Hutch Cancer Center Sloan Clinic 2
Seattle, Washington, United States, 98109
Actively Recruiting
37
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States, 98109
Actively Recruiting
38
Icon Cancer Centre Kurralta Park
Kurralta Park, Australia, 5037
Actively Recruiting
39
Peter MacCallum Cancer Centre
Melbourne, Australia, 3000
Actively Recruiting
40
Sydney Adventist Hospital
Wahroonga, Australia, 2076
Actively Recruiting
41
Princess Alexandra Hospital
Woolloongabba, Australia, 4102
Actively Recruiting
42
AZORG campus Aalst Moorselbaan
Aalst, Belgium, 9300
Actively Recruiting
43
ZAS Augustinus
Antwerp, Belgium, 2610
Actively Recruiting
44
AZ Maria Middelares
Ghent, Belgium, 9000
Actively Recruiting
45
Chu Helora Hospital La Louviere Site Jolimont
La Louvière, Belgium, 7100
Actively Recruiting
46
CHC MontLegia
Liège, Belgium, 4000
Actively Recruiting
47
NAIC Nair Antunes Instituto do Cancer
Bauru, Brazil, 17033-495
Actively Recruiting
48
Liga Norte Riograndense Contra O Cancer
Natal, Brazil, 59062 000
Actively Recruiting
49
Hospital Ana Nery Santa Cruz do Sul
Santa Cruz do Sul, Brazil, 96835-100
Actively Recruiting
50
CEPHO Centro de Estudos e Pesquisa de Hematologia e Oncologia
Santo André, Brazil, 09060 870
Actively Recruiting
51
ESHO Empresa De Servicos Hospitalares S A
São Paulo, Brazil, 01232 010
Actively Recruiting
52
The Ottawa Hospital Cancer Centre
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
53
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
54
Centre de Recherche du CHUM
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
55
CHU de Quebec Universite Laval
Québec, Quebec, Canada, G1R 2J6
Actively Recruiting
56
Beijing Luhe Hospital, Capital Medical University
Beijing, China, 101100
Actively Recruiting
57
The Third People's Hospital of Chengdu
Chengdu, China, 610014
Actively Recruiting
58
West China Hospital Sichuan University
Chengdu, China, 610041
Actively Recruiting
59
Chongqing University Cancer Hospital
Chongqing, China, 400030
Actively Recruiting
60
Sun Yat Sen University Cancer Center
Guangzhou, China, 510060
Actively Recruiting
61
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510120
Actively Recruiting
62
Sir Run Run Shaw Hospital Zhejiang University School of Medicine
Hangzhou, China, 310009
Actively Recruiting
63
Nanjing Drum Tower Hospital
Nanjing, China, 210009
Actively Recruiting
64
Shanghai General Hospital
Shanghai, China, 200080
Actively Recruiting
65
The Second Hospital Of Tianjin Medical University
Tianjin, China, 300211
Actively Recruiting
66
The Central Hospital of Wuhan
Wuhan, China, 430014
Actively Recruiting
67
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, China, 710061
Actively Recruiting
68
Centre Jean Perrin
Clermont-Ferrand, France, 63011
Actively Recruiting
69
Centre Oscar Lambret
Lille, France, 59000
Actively Recruiting
70
Centre Leon Berard
Lyon, France, 69008
Actively Recruiting
71
Groupe Hospitalo-Universitaire Carémeau
Nîmes, France, 30900
Actively Recruiting
72
Hopital Europeen Georges-Pompidou
Paris, France, 75908
Actively Recruiting
73
Gustave Roussy
Villejuif, France, 94800
Actively Recruiting
74
Urologicum Duisburg
Duisburg, Germany, 47169
Actively Recruiting
75
Studienpraxis Urologie Drs. Feyerabend
Nürtingen, Germany, 72622
Actively Recruiting
76
Istituto Europeo di Oncologia
Milan, Italy, 20141
Actively Recruiting
77
Istituto Nazionale Tumori Regina Elena
Roma, Italy, 00144
Actively Recruiting
78
Juntendo University Hospital
Bunkyō City, Japan, 113 8431
Actively Recruiting
79
Kansai Medical University Hospital
Hirakata, Japan, 573-1191
Actively Recruiting
80
Kanazawa University Hospital
Kanazawa, Japan, 920 8641
Actively Recruiting
81
Kitasato University Hospital
Sagamihara, Japan, 252-0375
Actively Recruiting
82
Shizuoka Cancer Center
Sunto Gun, Japan, 411 8777
Actively Recruiting
83
Yokohama City University Medical Center
Yokohama, Japan, 232 0024
Actively Recruiting
84
Hospital Wanita dan Kanak-Kanak Sabah
Kota Kinabalu, Malaysia, 88996
Actively Recruiting
85
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia, 50586
Actively Recruiting
86
University Malaya Medical Centre
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
87
Hospital Umum Sarawak
Kuching, Malaysia, 93586
Actively Recruiting
88
Pan American Center for Oncology Trials LLC
San Juan, Puerto Rico, 935
Actively Recruiting
89
National Cancer Center
Goyang-si, South Korea, 10408
Actively Recruiting
90
Severance Hospital Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
91
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
92
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
93
The Catholic University of Korea Seoul St Marys Hospital
Seoul, South Korea, 06591
Actively Recruiting
94
Hosp. Univ. Ramon Y Cajal
Madrid, Spain, 28034
Actively Recruiting
95
Hosp. Univ. 12 de Octubre
Madrid, Spain, 28041
Actively Recruiting
96
Hosp. Gral. Univ. J.M. Morales Meseguer
Murcia, Spain, 30008
Actively Recruiting
97
Hosp. Virgen Macarena
Seville, Spain, 41009
Actively Recruiting
98
Hosp. Gral. Univ. Valencia
Valencia, Spain, 46014
Actively Recruiting
99
Hosp. Clinico Univ. Lozano Blesa
Zaragoza, Spain, 50009
Actively Recruiting
100
China Medical University Hospital
Taichung, Taiwan, 404
Actively Recruiting
101
Taichung Veterans General Hospital
Taichung, Taiwan, 407219
Actively Recruiting
102
Tungs' Taichung MetroHarbor Hospital
Taichung, Taiwan, 435
Actively Recruiting
103
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
104
Linkou Chang Gung Memorial Hospital
Taoyuan, Taiwan, 333
Actively Recruiting
105
Adana City Hospital
Adana, Turkey (Türkiye), 01170
Actively Recruiting
106
Gulhane Training and Research Hospital
Ankara, Turkey (Türkiye), 06010
Actively Recruiting
107
Ankara University Medical Faculty
Ankara, Turkey (Türkiye), 06100
Actively Recruiting
108
Istanbul University Cerrahpasa tip Fakultesi
Istanbul, Turkey (Türkiye), 34096
Actively Recruiting
109
Koc Universitesi Hastanesi
Istanbul, Turkey (Türkiye), 34147
Actively Recruiting
110
Medicana International Izmir
Izmir, Turkey (Türkiye), 35170
Actively Recruiting
111
Velindre Cancer Centre
Cardiff, United Kingdom, CF14 2TL
Actively Recruiting
112
Beatson West Of Scotland Cancer Centre
Glasgow, United Kingdom, G12 0YN
Actively Recruiting
113
St Bartholomews Hospital
London, United Kingdom, EC1A 7BE
Actively Recruiting
114
The Royal Marsden NHS Trust
London, United Kingdom, SW3 6JJ
Actively Recruiting
115
The Newcastle upon Tyne Hospitals NHS Trust - Freeman Hospit
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
116
Lancashire Teaching Hospitals NHS Foundation Trust Royal Preston Hospital
Preston, United Kingdom, PR2 9HT
Actively Recruiting
117
Royal Marsden Hospital
Sutton, United Kingdom, SM2 5PT
Actively Recruiting
Research Team
S
Study Contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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