Actively Recruiting
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Led by Gilead Sciences · Updated on 2026-04-29
695
Participants Needed
205
Research Sites
234 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical study is to learn more about the study drug sacituzumab govitecan (SG; Trodelvy®; GS-0132; IMMU 132), versus standard of care (SOC) in participants with previously treated extensive stage small cell lung cancer (ES-SCLC). The primary objectives of this study are to compare the effect of SG to SOC on overall survival (OS).
CONDITIONS
Official Title
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed diagnosis of small cell lung cancer (SCLC)
- ECOG performance status score of 0 or 1
- Measurable disease by CT or MRI assessed by RECIST v1.1 criteria
- Radiological disease progression after 1 prior line of platinum-containing chemotherapy with or without PD-(L)1 therapy for ES-SCLC
- Prior platinum-based therapy for limited stage SCLC counts as 1 prior line if progression occurred within 30 to 180 days from last dose
- Participants treated with tarlatamab prior may participate
- At least 85% of participants must have been pretreated with anti-PD-(L)1 therapy
- Must meet country-specific requirements for participants in China
You will not qualify if you...
- Chemotherapy-free interval from last first-line platinum chemotherapy to progression less than 30 days
- Prior treatment with irinotecan, topotecan, sacituzumab govitecan, SN-38, exatecan derivatives, or similar topoisomerase I agents
- Received lurbinectedin after progression on or after platinum chemotherapy
- Presence of carcinomatous or non-carcinomatous meningitis CNS metastasis except for specific treated or stable brain metastases
- Untreated, clinically stable brain metastases allowed if asymptomatic, no immediate CNS treatment needed, lesions 5 mm or less, and 3 or fewer lesions
- Other protocol-defined criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 205 locations
1
Los Angeles Cancer Network
Anaheim, California, United States, 92801
Actively Recruiting
2
Boca Raton Regional
Miami, Florida, United States, 33143
Actively Recruiting
3
Hope and Healing Cancer Services
Hinsdale, Illinois, United States, 60521
Actively Recruiting
4
Southern Illinois University School of Medicine
Springfield, Illinois, United States, 62702
Actively Recruiting
5
Springfield Clinic
Springfield, Illinois, United States, 62702
Actively Recruiting
6
Parkview Research Center
Fort Wayne, Indiana, United States, 46845
Actively Recruiting
7
IU Health Ball Memorial Hospital and Physicians - Cancer Center - Muncie
Muncie, Indiana, United States, 47303
Actively Recruiting
8
Northwest Cancer Centers
Dyer, Kentucky, United States, 46311
Actively Recruiting
9
St. Claire Regional Medical Ce
Morehead, Kentucky, United States, 40351
Actively Recruiting
10
New Mexico Oncology Hematology Consultants, Ltd
Albuquerque, New Mexico, United States, 87109
Actively Recruiting
11
University Hospitals Seidman Cancer Center
Sandusky, Ohio, United States, 44870
Actively Recruiting
12
Taylor Cancer Research Foundation
Toledo, Ohio, United States, 43617
Actively Recruiting
13
Spoknwrd Clinical Trials Inc.
Easton, Pennsylvania, United States, 18045
Actively Recruiting
14
Hendrick Health System
Abilene, Texas, United States, 79601
Actively Recruiting
15
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
16
Texas Oncology - San Antonio
New Braunfels, Texas, United States, 78130
Actively Recruiting
17
The University of Texas Health Science Center at Tyler
Tyler, Texas, United States, 75708
Actively Recruiting
18
Gundersen Health System
West Salem, Wisconsin, United States, 54601
Actively Recruiting
19
Hospital Britanico de Buenos Aires
Buenos Aires, Argentina, 1280
Actively Recruiting
20
Universidad de Buenos Aires - Facultad de Medicina - Instituto Alexander Fleming (Buenos Aires)
Buenos Aires, Argentina, C1426ANZ
Actively Recruiting
21
Clinica Colon S.A.A (Clinica y Maternidad Colon) Investigaciones Clinicas de Mar del Plata
Buenos Aires, Argentina
Actively Recruiting
22
Centro Oncologico de Excelencia (San Juan)
San Juan, Argentina
Actively Recruiting
23
Centro Médico San Roque
San Miguel de Tucumán, Argentina, T4000IAN
Actively Recruiting
24
Sanatorio Parque SA
Santa Fe, Argentina, 2000
Actively Recruiting
25
Cancer Care Wollongong
New South Wales, New South Wales, Australia, 2500
Actively Recruiting
26
Metro North HHS (The Prince Charles Hospital)
Queensland, Queensland, Australia, 4006
Actively Recruiting
27
Gold Coast University Hospital
Southport, Queensland, Australia, 4215
Actively Recruiting
28
Cancer Research SA
Adelaide, South Australia, Australia, 5000
Actively Recruiting
29
St Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia, 3065
Actively Recruiting
30
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
31
Grand Hopital de Charleroi
Charleroi, Belgium, 6000
Actively Recruiting
32
Jessa Ziekenhuis
Hasselt, Belgium, 3500
Actively Recruiting
33
Centre Hospitalier Universitaire de Liege Avenue de Lhopital 1
Liège, Belgium, 4000
Actively Recruiting
34
AZ Delta
Roeselare, Belgium, 8800
Actively Recruiting
35
Vitaz
Sint-Niklaas, Belgium, 9100
Actively Recruiting
36
Instituto do Cancer do Ceara
Fortaleza Ceara, Brazil, 60430-230
Actively Recruiting
37
Hospital de Caridade de Ijui
Ijuí, Brazil, 98700-000
Actively Recruiting
38
Liga Norte-Rio-Grandense Contra o Cancer - Pesquisa Clinica
Natal, Brazil, 59062-000
Actively Recruiting
39
Hospital Mae de Deus
Porto Alegre, Brazil, 90110-270
Actively Recruiting
40
Hospital Sao Lucas da PUC Rio Grande do Sul
Porto Alegre, Brazil, 90610-000
Actively Recruiting
41
IMIP - Instituto de Medicina Integral Professor Fernando Figueira
Recife Pernambuco, Brazil, 50070-550
Actively Recruiting
42
Grupo Oncoclínicas
Santa Lúcia, Brazil, 30360-680
Actively Recruiting
43
Centro de Estudos e Pesquisa de Hematologia e Oncologia
Santo André, Brazil, 09060-650
Actively Recruiting
44
Instituto Hemomed Oncologia e Hematologia
São Paulo, Brazil, 01227-200
Actively Recruiting
45
Fundação Pio XII - Hospital de Amor
São Paulo, Brazil, 14784400
Actively Recruiting
46
HB Onco
São Paulo, Brazil, 15090-000
Actively Recruiting
47
Hospital Amaral Carvalho
São Paulo, Brazil, 17210-080
Actively Recruiting
48
Royal Victoria Regional Health Centre
Barrie, Canada, L4M 6M2
Actively Recruiting
49
Hamilton Health Sciences - Juravinski Cancer Centre
Hamilton, Canada, L8V 1C3
Actively Recruiting
50
McGill University
Montreal, Canada, H4A 3J1
Actively Recruiting
51
CISSS BSL / Hopital regional de Rimouski
Rimouski, Canada, G5L 5T1
Actively Recruiting
52
Sunnybrook Health Sciences Centre
Toronto, Canada, M4N 3M5
Actively Recruiting
53
Beijing Cancer Hospital
Beijing, China, 100142
Actively Recruiting
54
Jilin Cancer Hospital
Changchun, China, 130012
Actively Recruiting
55
Sichuan Cancer Hospital
Chengdu, China, 610041
Actively Recruiting
56
Chongqing University Cancer Hospital
Chongqing, China, 404100
Actively Recruiting
57
Fujian Medical University Union Hospital
Fuzhou, China, 350001
Actively Recruiting
58
Sun Yat-sen University Cancer Center
Guangzhou, China, 130012
Actively Recruiting
59
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, China, 510080
Actively Recruiting
60
Zhejiang Cancer Hospital
Hangzhou, China, 310000
Actively Recruiting
61
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China, 310009
Actively Recruiting
62
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, China, 310016
Actively Recruiting
63
The First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China, 552440
Actively Recruiting
64
Harbin Medical University Cancer Hospital
Harbin, China, 150081
Actively Recruiting
65
The Second Affiliated Hospital of Nanchang University
Jiangxi, China, 330008
Actively Recruiting
66
Affiliated Cancer Hospital of Shandong First Medical University
Jinan, China, 250021
Actively Recruiting
67
The Second Affiliated Hospital of Kunming Medical University
Kunming, China, 650000
Actively Recruiting
68
Linyi Cancer Hospital
Linyi, China, 276000
Actively Recruiting
69
The First Affiliated Hospital of Nanchang University
Nanchang, China, 330019
Actively Recruiting
70
Jiangsu Cancer Hospital
Nanjing, China, 210009
Actively Recruiting
71
Shanghai Chest Hospital
Shanghai, China, 200030
Actively Recruiting
72
Shanghai East Hospital
Shanghai, China, 200123
Actively Recruiting
73
Fudan University Shanghai Cancer Center
Shanghai, China
Actively Recruiting
74
Shanxi Provincial Cancer Hospital
Shanxi, China, 030013
Actively Recruiting
75
Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center
Shenzhen, China
Actively Recruiting
76
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China, 300181
Actively Recruiting
77
Weifang No.2 People's Hospital
Weifang, China, 261041
Actively Recruiting
78
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China, 430030
Actively Recruiting
79
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China, 430030
Actively Recruiting
80
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China, 710061
Actively Recruiting
81
The First Affiliated Hospital of Xiamen University
Xiamen, China, 361003
Actively Recruiting
82
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, China, 453100
Actively Recruiting
83
Northern Jiangsu People's Hospital
Yangzhou, China, 225001
Actively Recruiting
84
Henan Provincial Cancer Hospital
Zhengzhou, China, 450008
Actively Recruiting
85
CHU Angers - Hôpital Larrey
Angers, France, 49933
Actively Recruiting
86
Centre Hospitalier Intercommunal de Créteil
Créteil, France, 94000
Actively Recruiting
87
CHU Grenoble Alpes - Hopital Albert Michallon
La Tronche, France, 38700
Actively Recruiting
88
Hôpital Lyon Sud - Hospices Civils de Lyon
Lyon, France, 69003
Actively Recruiting
89
Assistance Publique - Hopitaux de Marseille, Hopital Nord
Marseille, France, 13005
Actively Recruiting
90
Hopital Tenon - Assistance Publique Hopitaux de Paris
Paris, France, 75020
Actively Recruiting
91
Institut Curie
Paris, France, 75248
Actively Recruiting
92
Hopital Haut-Leveque
Pessac, France, 33604
Actively Recruiting
93
CHU Rennes - Hopital Pontchaillou
Rennes, France, 35033
Actively Recruiting
94
Centre Hospitalier Universitaire de Nantes
Saint-Herblain, France, 44805
Actively Recruiting
95
Hopital Saint Joseph - Paris
Saint-Mandé, France, 94160
Actively Recruiting
96
CHU Strasbourg - Nouvel Hopital Civil
Strasbourg, France, 67091
Actively Recruiting
97
Augusta-Kranken-Anstalt gGmbH, Klinik f. Haematologie u. internistische Onkologie
Bochum, Germany, 44791
Actively Recruiting
98
Klinikum Chemnitz gGmbH
Chemnitz, Germany, 9113
Actively Recruiting
99
Klinikum Esslingen GmbH, Klinik fur Kardiologie, Angiologie and Pneumologie
Esslingen am Neckar, Germany, 73730
Actively Recruiting
100
UKE Hamburg-Eppendorf fur Onkologie
Hamburg, Germany, 20251
Actively Recruiting
101
Katholisches Marienkrankenhaus gGmbH
Hamburg, Germany, 22087
Actively Recruiting
102
Johannes Wesling Klinikum Minden
Minden, Germany, 32429
Actively Recruiting
103
Anticancer-Oncology Hospital of Athens 'Agios Sawas' 1st Pathology-Oncology Department
Athens, Greece, 11522
Actively Recruiting
104
Henry Dunant Hospital Center, 4th Oncology Clinic
Athens, Greece, 11526
Actively Recruiting
105
Metropolitan Hospital
Athens, Greece, 185 47
Actively Recruiting
106
University General Hospital of Larissa Department of Medical Oncology
Larissa, Greece, 41110
Actively Recruiting
107
University General Hospital of Patras, Division of Oncology
Rio, Greece, 26500
Actively Recruiting
108
St Luke's Hospital Oncology Department, Panorama
Thessaloniki, Greece, 552 36
Actively Recruiting
109
Interbalkan Hospital of Thessaloniki
Thessaloniki, Greece, 57001
Actively Recruiting
110
Bacs-Kiskun Varmegyei Oktatokorhaz, Onkoradiologiai Kozpont
Kecskemét, Hungary, 6000
Actively Recruiting
111
Soroka Medical Center
Beersheba, Israel, 84001
Actively Recruiting
112
Rambam Health Care Campus
Haifa, Israel, 3109601
Actively Recruiting
113
Hadassah Medical Center
Jerusalem, Israel, 9112001
Actively Recruiting
114
Meir Medical Center
Kfar Saba, Israel, 44281
Actively Recruiting
115
Galilee Medical Center
Naharyia, Israel, 11111
Actively Recruiting
116
Fondazione IRCCS - Istituto Nazionale dei Tumori di Milano
Aviano, Italy, 33081
Actively Recruiting
117
IRCCS Candiolo - Istituto di Ricerca
Candiolo, Italy, 10060
Actively Recruiting
118
Ospedale San Luca - Lucca
Lucca, Italy, 55100
Actively Recruiting
119
ASST - Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
120
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale Naples
Naples, Italy, 80131
Actively Recruiting
121
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
Naples, Italy, 80131
Actively Recruiting
122
Azienda Sanitaria Territoriale Pesaro e Urbino (AST)
Pesaro, Italy, 61122
Actively Recruiting
123
Casa di cura Pederzoli
Peschiera del Garda, Italy, 37019
Actively Recruiting
124
Istituti di Ricovero e Cura A Carattere Scientifico - Istituti Fisioterapici Ospitalieri
Roma, Italy, 144
Actively Recruiting
125
Universita Cattolica del Sacro Cuore
Roma, Italy, 168
Actively Recruiting
126
Nagoya University Hospital
Aichi, Japan, 466-8560
Actively Recruiting
127
Shikoku Cancer Center
Ehime, Japan, 791-0245
Actively Recruiting
128
Kyushu University Hospital
Fukuoka, Japan, 812-8582
Actively Recruiting
129
Kurume University Hospital
Fukuoka, Japan, 830-0011
Actively Recruiting
130
Hiroshima City Hiroshima Citizens Hospital
Hiroshima, Japan, 730-8518
Actively Recruiting
131
Hyogo Cancer Center
Hyōgo, Japan, 673-8558
Actively Recruiting
132
Kanagawa Cancer Center
Kanagawa, Japan, 241-0815
Actively Recruiting
133
Kobe City Medical Center General Hospital
Kobe, Japan, 650-0047
Actively Recruiting
134
Sendai Kousei Hospital
Miyagi, Japan, 981-0914
Actively Recruiting
135
Niigata University Medical & Dental Hospital
Nigata-shi, Japan, 9518520
Actively Recruiting
136
Okayama University Hospital
Okayama, Japan, 700-8558
Actively Recruiting
137
Osaka City General Hospital
Osaka, Japan, 534-0021
Actively Recruiting
138
Kansai Medical University Hospital
Osaka, Japan, 573-1191
Actively Recruiting
139
Kindai University Hospital
Osaka, Japan, 589-8511
Actively Recruiting
140
National Hospital Organization Kinki Chuo Chest Medical Center
Osaka, Japan, 591-8555
Actively Recruiting
141
Saitama Prefectural Cancer Center
Saitama, Japan, 362-0806
Actively Recruiting
142
Juntendo University School of Medicine Juntendo Clinic
Tokyo, Japan, 113-8431
Actively Recruiting
143
Nippon Medical School (all Hospitals)
Tokyo, Japan, 113-8603
Actively Recruiting
144
The Cancer Institute Hospital of JFCR
Tokyo, Japan, 135-8550
Actively Recruiting
145
Pantai Hospital Kuala Lumpur
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
146
Beacon Hospital
Kuala Selangor, Malaysia, 46050
Actively Recruiting
147
Sunway Medical Centre
Kuala Selangor, Malaysia, 47500
Actively Recruiting
148
Sarawak General Hospital
Kuching, Malaysia, 93586
Actively Recruiting
149
University Malaya Medical Centre
Lembah Pantai, Malaysia, 59100
Actively Recruiting
150
Amsterdam UMC, Locatie VUMC
Amsterdam, Netherlands, 1081 HV
Actively Recruiting
151
Zuyderland Medisch Centrum
Heerlen, Netherlands, 6419 PC
Actively Recruiting
152
Frisius MC location Leeuwarden
Leeuwarden, Netherlands, 8934 AD
Actively Recruiting
153
Maastricht University Medical Center
Maastricht, Netherlands, 6229 HX
Actively Recruiting
154
Sint Antonius Ziekenhuis
Utrecht, Netherlands, 3543 AZ
Actively Recruiting
155
Haukeland University hospital
Bergen, Norway, 5009
Actively Recruiting
156
Seksjon for kreftbehandling, Drammen Hospital
Drammen, Norway, 3004
Actively Recruiting
157
Oslo University Hospital
Oslo, Norway, 379
Actively Recruiting
158
Uniwersytet Medyczny w Lodzi
Lodz, Poland, 90-302
Actively Recruiting
159
Poznan University of Medical Sciences
Poznan, Poland, 60-693
Actively Recruiting
160
Podkarpackie Centrum Onkologii Rzeszow
Rzeszów, Poland, 35-055
Actively Recruiting
161
Mazowiecki Szpital Wojewódzki im. św. Jana Pawła II w Siedlcach
Siedlce, Poland, 08-110
Actively Recruiting
162
Wojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Słupsku
Stupsk, Poland, 076-200
Actively Recruiting
163
Spitalul Clinic Coltea
Bucharest, Romania, 30171
Actively Recruiting
164
S.C Radiotherapy Center Cluj S.R.L
Cluj-Napoca, Romania, 407 280
Actively Recruiting
165
S.C Centrul de Oncologie S.F Nectarie SRL
Craiova, Romania, 200347
Actively Recruiting
166
Institul Regional de Oncologie lasi;
Iași, Romania, 700483
Actively Recruiting
167
S.C Ovidius Clinical Hospital S.R.L
Ovidiu, Romania
Actively Recruiting
168
Spitalul Municipal Ploiesti
Ploieşti, Romania, 100337
Actively Recruiting
169
S.C Oncomed S.R.L
Timișoara, Romania, 300239
Actively Recruiting
170
Samsung Changwon Hospital
Changwon-Si, South Korea
Actively Recruiting
171
Chonnam National University Hwasun Hospital
Gwangju, South Korea, 61469
Actively Recruiting
172
Korea University Anam Hospital
Seongbuk-Gu, South Korea
Actively Recruiting
173
Seoul National University Bundang Hospital
Seongnam, South Korea, 13620
Actively Recruiting
174
Kangbuk Samsung Hospital
Seoul, South Korea, 03181
Actively Recruiting
175
Asan Medical Center
Seoul, South Korea, 05505
Actively Recruiting
176
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
177
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, South Korea, 06591
Actively Recruiting
178
Yonsei University Severance Hospital
Seoul, South Korea, 120-752
Actively Recruiting
179
Gyeongsang National University Hospital
Seoul, South Korea, 52727
Actively Recruiting
180
The Catholic University of Korea, St. Vincent's Hospital
Suwon, South Korea, 16247
Actively Recruiting
181
Ulsan University Hospital
Ulsan, South Korea, 44033
Actively Recruiting
182
Complejo Hospitalario Universitario A Coruña
A Coruña, Spain, 15006
Actively Recruiting
183
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
184
CEIC - Hospital Clinic i Provincial de Barcelona
Barcelona, Spain, 08036
Actively Recruiting
185
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08041
Actively Recruiting
186
ICO(Instituto Catalan de Oncologia) Badalona - Germans Trias i Pujol
Barcelona, Spain, 08916
Actively Recruiting
187
Institut Catala d'Oncologia Girona
Girona, Spain, 17007
Actively Recruiting
188
Complejo Hospitalario de Jaén
Jaén, Spain, 23007
Actively Recruiting
189
Complejo Hospitalario Universitario Insular Materno-Infantil
Las Palmas de Gran Canaria, Spain, 35016
Actively Recruiting
190
Hospital General Universitario Gregorio Maranon
Madrid, Spain, 28007
Actively Recruiting
191
Facultad de Medicina. Universidad Complutense de Madrid
Madrid, Spain, 28041
Actively Recruiting
192
Hospital Quironsalud Malaga
Málaga, Spain, 29010
Actively Recruiting
193
Hospital Universitario Virgen de Valme Sevilla
Seville, Spain, 41013
Actively Recruiting
194
Hospital Universitario Virgen de Valme
Seville, Spain, 41014
Actively Recruiting
195
Hospital Clínico Universitario de Valencia
Valencia, Spain, 46010
Actively Recruiting
196
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
197
Changhua Christian Hospital
Changhua, Taiwan, 500-06
Actively Recruiting
198
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 80756
Actively Recruiting
199
Taichung Veterans General Hospital
Taichung, Taiwan, 40705
Actively Recruiting
200
National Cheng Kung University Hospital
Tainan, Taiwan, 704
Actively Recruiting
201
Taipei Veterans General Hospital
Taipei, Taiwan, 10002
Actively Recruiting
202
National Taiwan University Cancer Center
Taipei, Taiwan, 100
Actively Recruiting
203
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, Taiwan, 112
Actively Recruiting
204
Chang Gung Memorial Hospital, Linkou
Taoyuan City, Taiwan, 33305
Actively Recruiting
205
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
G
Gilead Clinical Study Information Cente
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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