Actively Recruiting
A Study of Surgery and Radiotherapy in People With Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-14
178
Participants Needed
7
Research Sites
208 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
G
Gateway for Cancer Research
Collaborating Sponsor
AI-Summary
What this Trial Is About
The researchers are doing this study to see if the combination of surgery, locoregional radiation therapy, SBRT (stereotactic body radiation therapy), and the usual approach is more effective in treating oligometastatic HER2-positive breast cancer than the usual approach alone. The researchers will also study the side effects of the study treatment.
CONDITIONS
Official Title
A Study of Surgery and Radiotherapy in People With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �318 years.
- Pathologically-confirmed metastatic breast cancer.
- Oligometastatic breast cancer (�35 discrete metastatic lesions) without CNS involvement.
- HER2-positive breast cancer as determined by staff pathologist.
- All metastatic sites can be safely treated with SBRT or surgery.
- Enrolled at least 3 months (up to 12 months) after starting first-line systemic therapy without progression.
- ECOG performance status 0-2; Karnofsky performance status 60-100.
You will not qualify if you...
- Disease progression during the initial 3-12 months of first-line systemic therapy.
- Started second-line systemic therapy before enrollment.
- Health conditions preventing surgery, radiotherapy, or standard systemic therapy.
- Brain or intrathecal/intramedullary spinal disease involvement.
- Prior cancer treated with chemotherapy in the last 10 years.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities )
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All protocol activites)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
L
Lior Braunstein, MD
CONTACT
A
Atif Khan, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here