Actively Recruiting
Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies. An Italian Multicenter Study
Led by University of Bari Aldo Moro · Updated on 2024-07-05
115
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the thyroid health and bone metabolism in patients diagnosed with RASopathies, a group of genetic conditions confirmed by specific gene analysis. The main goal is to find out how common thyroid diseases and structural abnormalities of the thyroid gland are in these patients compared to the general population. They are also investigating the link between vitamin D deficiency or other bone metabolism issues and thyroid problems in this group. Participants will have blood tests to assess thyroid function, autoimmune markers, and bone metabolism indicators such as calcium, phosphorus, and vitamin D levels. They will also undergo a detailed color Doppler ultrasound of the thyroid gland to examine its size, structure, blood flow, and any nodules or lymph node changes. During the study, researchers will measure the number of patients with thyroid and bone abnormalities over six months. The study involves patients aged 3 to 25 years with genetically confirmed RASopathies. The overall participation includes clinical assessments, laboratory tests, and imaging to compare findings with those in the general population, providing a comprehensive view of these conditions.
CONDITIONS
Brief Title
Study of the Thyroid Function and Echostructural Morphology in Patients Affected With Rasopathies (ECORAS2023)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Genetically confirmed RASopathy
- Age between 3 and 25 years
You will not qualify if you...
- Previous radiotherapy treatments or known exposure to ionizing radiation
- Iodine deficiency
- Use of iodine-based compounds or drugs that interfere with thyroid function
- Congenital hypothyroidism or hyperthyroidism
- Severe obesity with metabolic complications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single visit during the study period
Participants undergo blood sampling to study thyroid function, autoimmunity, and bone metabolism biomarkers, along with a color Doppler ultrasound examination of the thyroid gland to assess its structure and potential abnormalities.
1 visit (in-person)
Duration - 6 months
Participants are observed for the presence of thyroid function abnormalities, ultrasound findings, and bone disease over a 6-month period.
Follow-up visits not specified
Trial Site Locations
Total: 1 location
1
University of Bari
Bari, Italy, 70124
Actively Recruiting
Research Team
M
Maria Felicia Faienza
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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