Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells.
Ramesh Chittajallu, Kurt Auville, Vivek Mahadevan...
https://pubmed.ncbi.nlm.nih.gov/32496194Actively Recruiting
Age: 8Years - 99Years
All Genders
ID01273129
Surgery as a Treatment for Medically Intractable Epilepsy
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-06-05
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying drug resistant epilepsy, which is epilepsy that does not respond to medication. This research aims to evaluate surgery as a treatment for children and adults with this condition, including those with tumor related epilepsy. The study collects data from standard epilepsy care to better understand epilepsy, its treatment, and the neurophysiological aspects of cognitive function. Participants 8 years and older who have seizures that are not controlled by medication may receive standard diagnostic and surgical treatments. These include brain imaging, invasive monitoring with intracranial electrodes, and surgical procedures such as temporal lobectomy, cortical resection, removal of brain lesions, and neurostimulator placement. Surgery aims to remove or modify the seizure focus while preserving important brain functions. Some patients may undergo invasive monitoring to guide treatment. During the study, participants will have medical and neurological evaluations, brain imaging, and video electroencephalography monitoring. They will be followed for up to two years after surgery with outpatient visits and brain scans at 2 months, 1 year, and 2 years. The research team will analyze clinical and neurophysiological data, including brain activity during cognitive tasks, to better understand epilepsy and cognitive function. Safety and follow-up care are part of the study process.
CONDITIONS
Brief Title
Surgery as a Treatment for Medically Intractable Epilepsy
Who Can Participate
Age: 8Years - 99Years
All Genders
Eligibility Criteria
You may qualify if you...
- Be 8 years of age or older with drug resistant epilepsy or tumor related epilepsy
You will not qualify if you...
- Unable or unwilling to give informed consent, or have a parent able to provide informed consent if a minor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Varies based on clinical indication
Participants undergo standard invasive and non-invasive diagnostic procedures including neurophysiologic monitoring to localize seizure focus as part of epilepsy surgery preparation.
Surgery and Immediate Post-operative Care
Duration - Varies depending on surgical procedure and immediate recovery
Participants receive standard epilepsy surgery procedures such as lobectomy, cortical resection, or neurostimulator placement based on clinical needs.
Post-operative Follow-up
Duration - 3 months
Participants are monitored with neurological examinations and brain MRI evaluations following surgery to assess recovery and outcomes.
Approximately 1 to 2 visits during the 3-month follow-up period
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
G
Gretchen C Scott, R.N.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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