Systems-Level Analyses of Immune Dysregulation in Patients and Healthy Controls with Sample Collection and Clinical Data

What this Trial Is About

Researchers are investigating immune dysregulation, a broad group of complex conditions where the immune system either overreacts, underreacts, or responds inappropriately. These conditions include immunodeficiencies, autoimmune disorders, autoinflammatory syndromes, severe allergies, and lymphoproliferation. The study aims to create a national resource in Sweden by collecting detailed immunological data and biological samples to better understand these diseases and their relationship with the microbiome. The study involves collecting primarily blood and fecal samples from both patients with confirmed or suspected immune dysregulation and healthy age- and sex-matched controls. Participants include those receiving various immunomodulatory therapies, and samples are taken before and during treatment. The project also establishes a national database housing deep immunological data alongside clinical outcomes, accessible to researchers and clinicians. Participants will provide samples over the course of their care, allowing researchers to analyze immune cell composition, functional responses, and microbiome differences. The primary outcome measure is the control of immune dysregulation within 1 to 3 months from the start of therapy. Exploratory immunological parameters will also be assessed during this period. This observational study enables comprehensive immune system analyses without altering participants' standard treatments.

SYSTEMS-LEVEL ANALYSES OF IMMUNE DYSREGULATION