Actively Recruiting
Led by Alliance for Clinical Trials in Oncology · Updated on 2026-06-02
364
Participants Needed
185
Research Sites
214 weeks
Total Duration
A
Alliance for Clinical Trials in Oncology
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
Researchers are investigating treatments for patients with colorectal cancer that has spread to up to four body sites, a condition called limited metastatic colorectal cancer. This phase III trial compares the usual systemic therapy, which includes intravenous and/or oral medications to control cancer growth and spread, with the addition of total ablative therapy (TAT). The aim is to see if adding focused treatments like stereotactic ablative radiotherapy (SABR), surgical removal, or microwave ablation can improve outcomes by eliminating cancer at metastatic sites. These ablative treatments have been tested for safety but their benefit in this cancer stage is still being evaluated. Participants are randomly assigned to one of two groups. One group receives total ablative therapy, which may include SABR, surgery, and/or microwave ablation, plus standard chemotherapy. The other group receives only the usual chemotherapy without ablative therapy. Throughout the trial, patients undergo imaging scans such as CT, MRI, or PET/CT to monitor the cancer. The study measures overall survival, event-free survival, adverse events, and time to local recurrence over up to five years. During the study, patients will have regular evaluations including imaging scans to track their cancer status. Researchers will monitor survival time from randomization, any cancer progression or recurrence, and side effects from treatments. The study also assesses how long before the cancer returns at treated sites. Safety and effectiveness data will be collected for up to five years to understand the impact of adding ablative therapy to standard systemic treatment. Total participation duration depends on individual follow-up but may last several years.
CONDITIONS
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 24 weeks or as determined by treatment plan
Participants receive systemic chemotherapy as standard of care. Participants randomized to the experimental arm also undergo total ablative therapy (TAT), which may include stereotactic ablative radiotherapy (SABR), surgical resection, and/or microwave ablation. Imaging scans such as CT, MRI, or PET/CT are performed throughout this period to monitor disease.
Multiple visits for chemotherapy and ablative therapy; imaging scans performed periodically throughout treatment
Duration - Up to 5 years
Participants are monitored for overall survival, event-free survival, adverse events, and time to local recurrence for up to 5 years after treatment completion.
Periodic visits for assessments and imaging scans
Total: 185 locations
1
Kingman Regional Medical Center
Kingman, Arizona, United States, 86401
Actively Recruiting
2
Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
Tower Cancer Research Foundation
Beverly Hills, California, United States, 90211
Actively Recruiting
4
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States, 92612
Actively Recruiting
5
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
6
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, United States, 92868
Actively Recruiting
7
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Active, Not Recruiting
8
Beebe Medical Center
Lewes, Delaware, United States, 19958
Actively Recruiting
9
Beebe South Coastal Health Campus
Millville, Delaware, United States, 19967
Actively Recruiting
10
Helen F Graham Cancer Center
Newark, Delaware, United States, 19713
Actively Recruiting
11
Medical Oncology Hematology Consultants PA
Newark, Delaware, United States, 19713
Actively Recruiting
12
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States, 19718
Actively Recruiting
13
Beebe Health Campus
Rehoboth Beach, Delaware, United States, 19971
Actively Recruiting
14
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States, 19801
Actively Recruiting
15
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Active, Not Recruiting
16
George Washington University Medical Center
Washington D.C., District of Columbia, United States, 20037
Actively Recruiting
17
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States, 33146
Actively Recruiting
18
UM Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida, United States, 33065
Actively Recruiting
19
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States, 33442
Actively Recruiting
20
UM Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, United States, 33166
Actively Recruiting
21
UF Health Cancer Institute - Gainesville
Gainesville, Florida, United States, 32610
Actively Recruiting
22
UM Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida, United States, 33021
Actively Recruiting
23
Jupiter Medical Center
Jupiter, Florida, United States, 33458
Active, Not Recruiting
24
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States, 33136
Actively Recruiting
25
Miami Cancer Institute
Miami, Florida, United States, 33176
Active, Not Recruiting
26
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States, 33176
Actively Recruiting
27
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States, 33324
Actively Recruiting
28
Grady Health System
Atlanta, Georgia, United States, 30303
Actively Recruiting
29
Emory Proton Therapy Center
Atlanta, Georgia, United States, 30308
Actively Recruiting
30
Emory University Hospital Midtown
Atlanta, Georgia, United States, 30308
Actively Recruiting
31
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, United States, 30322
Actively Recruiting
32
Emory Saint Joseph's Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
33
Saint Luke's Cancer Institute - Boise
Boise, Idaho, United States, 83712
Actively Recruiting
34
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, United States, 83619
Actively Recruiting
35
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, United States, 83642
Actively Recruiting
36
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, United States, 83687
Actively Recruiting
37
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, United States, 83301
Actively Recruiting
38
University of Illinois
Chicago, Illinois, United States, 60612
Actively Recruiting
39
Baptist Health Floyd
New Albany, Indiana, United States, 47150
Actively Recruiting
40
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa, United States, 50023
Actively Recruiting
41
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa, United States, 52722
Actively Recruiting
42
Mercy Cancer Center-West Lakes
Clive, Iowa, United States, 50325
Actively Recruiting
43
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa, United States, 50325
Actively Recruiting
44
Greater Regional Medical Center
Creston, Iowa, United States, 50801
Actively Recruiting
45
Iowa Methodist Medical Center
Des Moines, Iowa, United States, 50309
Actively Recruiting
46
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa, United States, 50309
Actively Recruiting
47
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States, 50314
Actively Recruiting
48
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa, United States, 50314
Actively Recruiting
49
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, United States, 52242
Actively Recruiting
50
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa, United States, 50263
Actively Recruiting
51
Mercy Medical Center-West Lakes
West Des Moines, Iowa, United States, 50266
Actively Recruiting
52
University of Kentucky/Markey Cancer Center
Lexington, Kentucky, United States, 40536
Active, Not Recruiting
53
Baptist Health Louisville
Louisville, Kentucky, United States, 40207
Actively Recruiting
54
University Medical Center New Orleans
New Orleans, Louisiana, United States, 70112
Actively Recruiting
55
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, United States, 21287
Active, Not Recruiting
56
Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
57
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States, 48106
Actively Recruiting
58
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
59
Trinity Health Medical Center - Brighton
Brighton, Michigan, United States, 48114
Actively Recruiting
60
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan, United States, 48188
Actively Recruiting
61
Trinity Health Medical Center - Canton
Canton, Michigan, United States, 48188
Actively Recruiting
62
Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
63
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States, 48118
Actively Recruiting
64
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan, United States, 48038
Active, Not Recruiting
65
Corewell Health Dearborn Hospital
Dearborn, Michigan, United States, 48124
Actively Recruiting
66
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
67
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan, United States, 48336
Actively Recruiting
68
Genesys Hurley Cancer Institute
Flint, Michigan, United States, 48503
Actively Recruiting
69
Hurley Medical Center
Flint, Michigan, United States, 48503
Actively Recruiting
70
Allegiance Health
Jackson, Michigan, United States, 49201
Active, Not Recruiting
71
University of Michigan Health - Sparrow Lansing
Lansing, Michigan, United States, 48912
Actively Recruiting
72
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan, United States, 48154
Actively Recruiting
73
Henry Ford Health Providence Novi Hospital
Novi, Michigan, United States, 48374
Active, Not Recruiting
74
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, United States, 48073
Actively Recruiting
75
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan, United States, 48075
Active, Not Recruiting
76
Corewell Health Beaumont Troy Hospital
Troy, Michigan, United States, 48085
Actively Recruiting
77
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan, United States, 48322
Active, Not Recruiting
78
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan, United States, 48197
Actively Recruiting
79
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota, United States, 56601
Actively Recruiting
80
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
81
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi, United States, 39705
Actively Recruiting
82
Baptist Cancer Center-Grenada
Grenada, Mississippi, United States, 38901
Actively Recruiting
83
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi, United States, 38652
Actively Recruiting
84
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi, United States, 38655
Actively Recruiting
85
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi, United States, 38671
Actively Recruiting
86
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri, United States, 65212
Actively Recruiting
87
Parkland Health Center - Farmington
Farmington, Missouri, United States, 63640
Actively Recruiting
88
Heartland Regional Medical Center
Saint Joseph, Missouri, United States, 64506
Actively Recruiting
89
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri, United States, 63670
Actively Recruiting
90
Mercy Hospital Springfield
Springfield, Missouri, United States, 65804
Actively Recruiting
91
Mercy Hospital South
St Louis, Missouri, United States, 63128
Actively Recruiting
92
Missouri Baptist Medical Center
St Louis, Missouri, United States, 63131
Actively Recruiting
93
Mercy Hospital Saint Louis
St Louis, Missouri, United States, 63141
Actively Recruiting
94
Missouri Baptist Sullivan Hospital
Sullivan, Missouri, United States, 63080
Actively Recruiting
95
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri, United States, 63127
Actively Recruiting
96
Billings Clinic Cancer Center
Billings, Montana, United States, 59101
Actively Recruiting
97
Benefis Sletten Cancer Institute
Great Falls, Montana, United States, 59405
Actively Recruiting
98
Nebraska Medicine-Bellevue
Bellevue, Nebraska, United States, 68123
Actively Recruiting
99
Nebraska Medicine-Village Pointe
Omaha, Nebraska, United States, 68118
Actively Recruiting
100
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
101
Renown Regional Medical Center
Reno, Nevada, United States, 89502
Actively Recruiting
102
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
103
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
104
Englewood Hospital and Medical Center
Englewood, New Jersey, United States, 07631
Actively Recruiting
105
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States, 07748
Actively Recruiting
106
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States, 07645
Actively Recruiting
107
University of New Mexico Cancer Center
Albuquerque, New Mexico, United States, 87106
Actively Recruiting
108
New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn, New York, United States, 11215
Actively Recruiting
109
Memorial Sloan Kettering Commack
Commack, New York, United States, 11725
Actively Recruiting
110
The New York Hospital Medical Center of Queens
Flushing, New York, United States, 11355
Actively Recruiting
111
Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills, New York, United States, 11375
Actively Recruiting
112
Northwell Health Cancer Institute at Huntington
Greenlawn, New York, United States, 11740
Actively Recruiting
113
Memorial Sloan Kettering Westchester
Harrison, New York, United States, 10604
Actively Recruiting
114
Northwell Health/Center for Advanced Medicine
Lake Success, New York, United States, 11042
Actively Recruiting
115
Northern Westchester Hospital
Mount Kisco, New York, United States, 10549
Actively Recruiting
116
Mount Sinai West
New York, New York, United States, 10019
Actively Recruiting
117
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
118
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, United States, 10032
Active, Not Recruiting
119
Manhattan Eye Ear and Throat Hospital
New York, New York, United States, 10065
Actively Recruiting
120
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
121
NYP/Weill Cornell Medical Center
New York, New York, United States, 10065
Actively Recruiting
122
Lenox Hill Hospital
New York, New York, United States, 10075
Actively Recruiting
123
Queens Cancer Center
Rego Park, New York, United States, 11374
Actively Recruiting
124
University of Rochester
Rochester, New York, United States, 14642
Active, Not Recruiting
125
Phelps Memorial Hospital Center
Sleepy Hollow, New York, United States, 10591
Actively Recruiting
126
Memorial Sloan Kettering Nassau
Uniondale, New York, United States, 11553
Actively Recruiting
127
Westchester Medical Center
Valhalla, New York, United States, 10595
Actively Recruiting
128
Wilmot Cancer Institute at Webster
Webster, New York, United States, 14580
Active, Not Recruiting
129
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, United States, 28203
Actively Recruiting
130
Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina, United States, 28025
Actively Recruiting
131
East Carolina University
Greenville, North Carolina, United States, 27834
Actively Recruiting
132
Sanford Bismarck Medical Center
Bismarck, North Dakota, United States, 58501
Actively Recruiting
133
Sanford Broadway Medical Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
134
Sanford Roger Maris Cancer Center
Fargo, North Dakota, United States, 58122
Actively Recruiting
135
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio, United States, 45459
Active, Not Recruiting
136
Miami Valley Hospital South
Centerville, Ohio, United States, 45459
Actively Recruiting
137
MetroHealth Medical Center
Cleveland, Ohio, United States, 44109
Active, Not Recruiting
138
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States, 43210
Actively Recruiting
139
Miami Valley Hospital
Dayton, Ohio, United States, 45409
Actively Recruiting
140
Premier Blood and Cancer Center
Dayton, Ohio, United States, 45409
Actively Recruiting
141
Dayton Physician LLC - Englewood
Dayton, Ohio, United States, 45415
Active, Not Recruiting
142
Miami Valley Hospital North
Dayton, Ohio, United States, 45415
Actively Recruiting
143
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, United States, 45005-1066
Actively Recruiting
144
Dayton Physicians LLC-Atrium
Franklin, Ohio, United States, 45005
Active, Not Recruiting
145
Miami Valley Cancer Care and Infusion
Greenville, Ohio, United States, 45331
Actively Recruiting
146
Upper Valley Medical Center
Troy, Ohio, United States, 45373
Actively Recruiting
147
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States, 73104
Active, Not Recruiting
148
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
149
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, United States, 19317
Actively Recruiting
150
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
151
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, United States, 17033-0850
Actively Recruiting
152
Lancaster General Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, United States, 17601
Active, Not Recruiting
153
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States, 17837
Actively Recruiting
154
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
155
West Penn Hospital
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
156
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
157
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, United States, 57104
Actively Recruiting
158
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, United States, 57117-5134
Actively Recruiting
159
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee, United States, 38120
Actively Recruiting
160
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
161
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Withdrawn
162
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
163
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia, United States, 23116
Actively Recruiting
164
Bon Secours Saint Francis Medical Center
Midlothian, Virginia, United States, 23114
Actively Recruiting
165
Bon Secours Saint Mary's Hospital
Richmond, Virginia, United States, 23226
Actively Recruiting
166
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, Virginia, United States, 23230
Actively Recruiting
167
Valley Medical Center
Renton, Washington, United States, 98055
Actively Recruiting
168
Edwards Comprehensive Cancer Center
Huntington, West Virginia, United States, 25701
Actively Recruiting
169
Langlade Hospital and Cancer Center
Antigo, Wisconsin, United States, 54409
Actively Recruiting
170
Ascension Saint Elizabeth Hospital
Appleton, Wisconsin, United States, 54915
Actively Recruiting
171
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin, United States, 53045
Actively Recruiting
172
Ascension Calumet Hospital
Chilton, Wisconsin, United States, 53014
Actively Recruiting
173
Ascension Southeast Wisconsin Hospital - Franklin
Franklin, Wisconsin, United States, 53132
Actively Recruiting
174
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon, Wisconsin, United States, 53097
Actively Recruiting
175
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Milwaukee, Wisconsin, United States, 53210
Actively Recruiting
176
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee, Wisconsin, United States, 53211
Actively Recruiting
177
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
178
Ascension Mercy Hospital
Oshkosh, Wisconsin, United States, 54904
Actively Recruiting
179
Ascension All Saints Hospital
Racine, Wisconsin, United States, 53405
Actively Recruiting
180
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin, United States, 54501
Actively Recruiting
181
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin, United States, 54481
Actively Recruiting
182
Aspirus Regional Cancer Center
Wausau, Wisconsin, United States, 54401
Actively Recruiting
183
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa, Wisconsin, United States, 53226
Actively Recruiting
184
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin, United States, 54494
Actively Recruiting
185
Arthur J E Child Comprehensive Cancer Centre
Calgary, Alberta, Canada, T2N 5G2
Suspended
E
Eric D. Miller, MD, PhD
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Kathryn E Hitchcock, Eric D Miller, Qian Shi...
https://pubmed.ncbi.nlm.nih.gov/38350888Eric D Miller, Kathryn E Hitchcock, Paul B Romesser
https://pubmed.ncbi.nlm.nih.gov/36652155