Actively Recruiting
Thailand ATTR-CM Registry
Led by Mahidol University · Updated on 2025-05-08
105
Participants Needed
8
Research Sites
308 weeks
Total Duration
On this page
Sponsors
M
Mahidol University
Lead Sponsor
P
Pfizer
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators of this registry aim to study the natural history, clinical presentation, characteristics, and imaging findings of patients diagnosed with ATTR amyloidosis in Thailand longitudinally. This will enable the investigators to study this disease in depth. With a better understanding, the investigators can aim to develop early screening programs for at-risk patients, raising awareness among non-cardiologists. As amyloid-specific therapies have now become available in Thailand, the findings of this registry can be helpful for epidemiological studies in Thailand.
CONDITIONS
Official Title
Thailand ATTR-CM Registry
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Diagnosis of Transthyretin Amyloid Cardiomyopathy (ATTR-CM), symptomatic or asymptomatic
- Evidence of cardiac involvement by echocardiogram showing left ventricle wall thickness of 12 mm or more
- One or more of the following:
- Positive scintigraphy with 99mTC-DPD, 99mTC-PYP, or 99mTC-HMDP showing Perugini grade 2 or higher and/or heart to contralateral lung ratio over 1.5
- Positive scintigraphy with Perugini grade 1 plus positive cardiac biopsy with Congo red stain in 4 or more sites
- Positive scintigraphy with Perugini grade 1 plus positive non-cardiac biopsy with Congo red stain
- Abnormal cardiac MRI with subendocardium late gadolinium enhancement and/or elevated native T1 value and/or increased extracellular volume over 0.4 plus positive cardiac or non-cardiac biopsy with Congo red stain
You will not qualify if you...
- Amyloidosis caused by proteins other than transthyretin, such as light chain amyloidosis
- Secondary amyloidosis diagnosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Faculty of Medicine at Chulalongkorn University
Bangkok, Thailand
Not Yet Recruiting
2
Faculty of Medicine Ramathibodi hospital, Mahidol University
Bangkok, Thailand
Not Yet Recruiting
3
Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand
Not Yet Recruiting
4
Phramongkutklao Hospital
Bangkok, Thailand
Not Yet Recruiting
5
Faculty of Medicine Chiang Mai University
Chiang Mai, Thailand
Not Yet Recruiting
6
Queen Sirikit Heart Center of The Northeast
Khon Kaen, Thailand
Not Yet Recruiting
7
Faculty of Medicine, Thammasat University
Pathum Thani, Thailand
Not Yet Recruiting
8
Prince of Songkla University
Songkhla, Thailand
Actively Recruiting
Research Team
K
Kanchalaporn Jirataiporn, B.N.S.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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