Study of Environmental Toxin Exposure, Immune Changes, and Genetic Factors in Military Patients with B-cell Non-Hodgkin Lymphoma

What this Trial Is About

Researchers are investigating how exposure to toxins at work and in the environment, inherited genetic differences, and immune system changes relate to B-cell non-Hodgkin lymphoma NHL in active-duty service members and other Military Health System beneficiaries. The study focuses on whether specific exposures and genetic variants are linked to different NHL subtypes, immune problems, and patient outcomes. This observational study follows participants for up to 3 years to understand these connections better. Participants will be enrolled into one of three groups based on their disease status and age those in remission, newly diagnosed adults not currently receiving treatment, and treatment-naive pediatric patients. The study collects detailed clinical, epidemiological, immunological, and genetic information over time. Participants complete surveys about demographics, military and medical history, and toxin exposures. Additional military exposure data may be gathered from official records. Throughout the study, clinical data such as lymphoma subtype, staging, treatments, and lab results will be reviewed. Biospecimens like blood, skin samples, bone marrow, and tumor tissue are collected for genetic and immune system testing. Researchers will analyze immune cell types, activation markers, and genetic variations using advanced sequencing. The main outcomes include characterizing toxin exposures, identifying genetic variants linked to lymphoma, and building a comprehensive database and biorepository for future research.

Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma