Actively Recruiting

Phase Not Applicable
Age: 24Months - 4Years
All Genders
Healthy Volunteers
NCT05957549

Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age

Led by Children's Hospital Medical Center, Cincinnati · Updated on 2025-07-10

90

Participants Needed

1

Research Sites

229 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Individuals with Fragile X Syndrome show differences in how they understand and learn language from infancy. They frequently have lifelong delays in speech and language as well. In addition, they experience other auditory symptoms, including being very sensitive to certain sounds as well as being more sensitive than others to loud sounds. The underlying brain activity for sound perception and speech learning in Fragile X is not well understood, especially in the infant, toddler, and preschool years. This study uses behavioral assessment of speech and language abilities, neuroimaging, and hearing tests to understand how speech and hearing are different in children with Fragile X Syndrome.

CONDITIONS

Official Title

Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age

Who Can Participate

Age: 24Months - 4Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Diagnoses of Fragile X Syndrome, Typical Development, or History of Premature Birth
  • Able to sit independently
  • English is spoken at home
Not Eligible

You will not qualify if you...

  • No seizures in the past 6 months
  • For typical development and Fragile X groups: not born prior to 32 weeks gestation

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Cincinnati Children'S Hospital

Cincinnati, Ohio, United States, 45229

Actively Recruiting

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Research Team

E

Elizabeth Smith, PhD

CONTACT

C

Craig Erickson, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

BASIC_SCIENCE

Number of Arms

1

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Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age | DecenTrialz