Actively Recruiting
VCRC Tissue Biorepository Collection Protocol for Vasculitis Research
Led by University of Pennsylvania · Updated on 2026-01-22
1000
Participants Needed
8
Research Sites
N/A
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
N
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to collect tissue samples from people enrolled in Vasculitis Clinical Research Consortium (VCRC) studies to better understand vasculitis, a group of autoimmune and inflammatory diseases affecting blood vessels. By analyzing these stored tissue specimens alongside clinical data, researchers hope to discover new causes, diagnostic methods, and treatments for vasculitis and related diseases. The study uses biopsy specimens previously collected as part of standard medical care, mainly from kidneys, lungs, skin, nerves, and blood vessels. No new biopsies will be performed for this study. Instead, consent will be sought to use existing samples for further research. Participants are involved by allowing their stored tissue samples to be used in research. Researchers will analyze these samples and linked clinical data to identify genes that may increase the risk of vasculitis within one year. The study is observational and involves no direct treatment, with involvement lasting as long as the tissue repository is maintained through 2028.
CONDITIONS
Brief Title
VCRC Tissue Repository
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Currently enrolled or previously enrolled in a Vasculitis Clinical Research Consortium (VCRC) observational or interventional study (protocols 5502, 5503, 5504, 5505, 5506, 5507, 5563, 5522, 5523, 5526, 5527, or 5562)
You will not qualify if you...
- Unable to give informed consent or have a guardian unable to provide consent for children
- Unwilling to allow the use of existing tissue samples for research purposes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Ongoing during participation
Participants provide consent to allow use of biopsy specimens collected during routine care for research purposes.
Consent collection visit (in-person or remote)
Duration - Up to 1 year
Participants are observed to identify genes that increase the risk of developing vasculitis over time.
Periodic assessments depending on study requirements
Trial Site Locations
Total: 8 locations
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Completed
2
Boston University School of Medicine
Boston, Massachusetts, United States, 02118
Completed
3
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Completed
4
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
5
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15261
Completed
6
University of Utah
Salt Lake City, Utah, United States, 84132
Completed
7
St. Joseph's Healthcare
Hamilton, Ontario, Canada, L8N 3B6
Actively Recruiting
8
University of Toronto Mount Sinai Hospital
Toronto, Ontario, Canada, M5G 1X5
Actively Recruiting
Research Team
K
Katie Doyle
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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