High-Resolution Study of Vestibulodynia Using Omics to Find Better Diagnostic Markers

What this Trial Is About

Vestibulodynia VBD is a common form of vulvodynia characterized by vulvar pain without a clear cause, lasting at least three months. It mainly affects sexually active women of reproductive age and is often underdiagnosed due to the absence of clear markers and sociocultural factors. Researchers are studying the diseases molecular markers and underlying mechanisms to improve diagnosis and treatment, aiming to identify specific markers through advanced genetic analysis. This observational study collects specimens such as vulvar biopsies and blood samples from women diagnosed with VBD and healthy controls. The study uses transcriptomic and single-cell omics analyses to discover molecular markers related to VBD. It aims to stratify patient groups based on these markers, helping future personalized medicine approaches. Participants will provide samples and undergo assessments over 12 months, during which molecular markers at the mRNA and protein levels will be measured. The study involves women aged 18 to 50, with certain exclusions to ensure accurate results. The research will help clinicians diagnose VBD earlier, guide therapies, and identify patients at risk of developing chronic symptoms.

Vestibulodynia At High Resolution: Omics Approach to Improve Diagnosis