Actively Recruiting
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
Led by The Florey Institute of Neuroscience and Mental Health · Updated on 2026-04-21
100
Participants Needed
2
Research Sites
47 weeks
Total Duration
On this page
Sponsors
T
The Florey Institute of Neuroscience and Mental Health
Lead Sponsor
U
University of Melbourne
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are conducting a small early-phase study in Melbourne, Australia, involving up to 100 young adults aged 18 to 55 who have experienced a stroke. The study aims to test how practical it is to use a detailed health assessment process called "deep phenotyping" with this group. This process collects a wide range of information and samples to better understand each participant's condition and explore factors that may influence stroke recovery, such as biological markers, age, sex, stroke type, lifestyle, and environment. Participants will be observed through this deep phenotyping process, which includes advanced MRI imaging and collecting samples like blood, saliva, urine, and hair for future analysis. A subgroup of about 20 participants may also undergo a special PET scan study to explore brain recovery using an experimental tracer. The study will also monitor physical activity and sleep using devices, assess environmental exposures, quality of life, resilience, and healthcare use, as well as track changes in medication and medical conditions. During the study, participants will have multiple assessments including fatigue scales, cognitive tests, walking tests, and measures of communication impact at various times up to six months after stroke. Researchers will evaluate how feasible and acceptable the deep phenotyping method is over the course of enrollment to the six-month follow-up. The study will last through these assessments, with detailed monitoring to understand recovery patterns and prepare for larger future studies.
CONDITIONS
Brief Title
Young Stroke Service Deep Phenotyping: Exploring Recovery in Young Adult Survivors of Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 18 and 55 years old
- Experienced an acute stroke confirmed by brain imaging or clinical diagnosis
- Stroke occurred within one month, or up to three months if earlier recruitment was not possible
You will not qualify if you...
- Severe or progressive illness with expected survival under 24 months
- Illness that may interfere with individual data importance (e.g., severe multiple sclerosis or dementia)
- Major psychiatric condition requiring medical treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 6 months
Participants undergo detailed assessments including MRI imaging, collection of blood, saliva, urine, and hair samples, and may participate in a PET scan sub study. Physical activity and sleep quality are tracked via wearable devices and self-report, along with assessments of personal and environmental factors.
Assessment visits at less than 1 month, 3 months, and 6 months post stroke
Trial Site Locations
Total: 2 locations
1
Austin Health
Heidelberg, Victoria, Australia, 3039
Actively Recruiting
2
Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre
Heidelberg, Victoria, Australia, 3084
Not Yet Recruiting
Research Team
E
Emily Ramage, BPhysio, PhD
M
Marie Ferraro, BSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here