Costs of topical treatment of pressure ulcer patients.
Cynthia Carolina Duarte Andrade, Cláudia Fernanda Dos Santos Calixto de Almeida, Walkíria Euzébio Pereira...
https://pubmed.ncbi.nlm.nih.gov/27384210Actively Recruiting
Phase 4
Age: 18Years +
All Genders
ID07193849
Impact of Using Zinc Oxide Versus Moist Exposed Wound Ointment (MEBO) in Treatment of Second Stage Pressure Ulcer: A Randomized Control Clinical Trial
Led by King Abdullah Medical City · Updated on 2025-09-26
76
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of zinc oxide compared to moist exposed wound ointment (MEBO) in treating second stage pressure ulcers. This randomized controlled trial aims to determine which topical treatment better supports healing of these ulcers, which are common in patients with prolonged pressure on the skin. The study is sponsored by King Abdullah Medical City and uses a validated wound assessment tool to measure healing progress. Participants will be randomly assigned to one of two groups: one receiving topical zinc oxide twice daily every 12 hours, and the other receiving topical MEBO ointment with the same frequency. The treatment period will last up to one month or until the ulcer completely heals. Daily examinations will be conducted to monitor wound status using the Bates-Jensen Wound Assessment Tool (BWAT). During the study, participants will undergo daily wound assessments until healing is complete or for a maximum of 30 days. Researchers will collect data on wound healing and recovery time. The study includes regular monitoring to track treatment effects and safety. Participation involves applying the assigned ointment twice daily and attending daily evaluations throughout the treatment period.
CONDITIONS
Brief Title
Zinc Oxide VS MEBO
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Willing to participate
- Patients in medical ward, neuroscience ward, or intensive care unit at KAMC
- Newly diagnosed with second stage pressure ulcer according to European and National Pressure Ulcer Advisory Panel guidelines
- Age 18 years or older
You will not qualify if you...
- Not consenting to participate
- Suspected hypersensitivity to any ingredient in the topical ointments
- Having category III or IV pressure ulcers
- Presence of deep tissue injury such as exudative drainage or blood-filled blisters
- Signs of wound infection including pus, foul smell, tenderness, heat, redness, or fever
- Receiving therapies that affect healing like corticosteroids, radiation, or chemotherapy
- Heavy smoking (more than 20 cigarettes a day)
- Having chronic diseases such as diabetes mellitus or vascular disease like Buerger's disease
- Unable to continue study due to death, discharge, or change in care setting
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 30 days or until complete healing
Participants receive topical zinc oxide or MEBO ointment applied twice every 12 hours daily to treat second stage pressure ulcers.
Daily visits until wound healing or 30 days
Trial Site Locations
Total: 2 locations
1
King Abdulla Medical City in Holy capital
Mecca, Western Reagan, Saudi Arabia, 24211
Actively Recruiting
2
King Abdulla Medical City in Holy capital
Mecca, Western Reagan, Saudi Arabia, 24211
Completed
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Research Team
W
wedian Almowallad, Master
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Review of the Current Management of Pressure Ulcers.
Tatiana V Boyko, Michael T Longaker, George P Yang
https://pubmed.ncbi.nlm.nih.gov/29392094The cost of prevention and treatment of pressure ulcers: A systematic review.
Liesbet Demarré, Aurélie Van Lancker, Ann Van Hecke...
https://pubmed.ncbi.nlm.nih.gov/26231383Risk assessment and prevention of pressure ulcers: a clinical practice guideline from the American College of Physicians.
Amir Qaseem, Tanveer P Mir, Melissa Starkey...
https://pubmed.ncbi.nlm.nih.gov/25732278Dressings and topical agents for treating pressure ulcers.
Maggie J Westby, Jo C Dumville, Marta O Soares...
https://pubmed.ncbi.nlm.nih.gov/28639707Results of the 2008-2009 International Pressure Ulcer Prevalence Survey and a 3-year, acute care, unit-specific analysis.
Catherine VanGilder, Stephanie Amlung, Patrick Harrison...
https://pubmed.ncbi.nlm.nih.gov/19934462Eliminating facility-acquired pressure ulcers at Ascension Health.
Wanda Gibbons, Helana T Shanks, Pam Kleinhelter...
https://pubmed.ncbi.nlm.nih.gov/17987872Development and implementation of a hospital-acquired pressure ulcer incidence tracking system and algorithm.
Sunniva Zaratkiewicz, Joanne D Whitney, Jeanne R Lowe...
https://pubmed.ncbi.nlm.nih.gov/20946425Moist exposed burn ointment for treating pressure ulcers: A multicenter randomized controlled trial.
Wei Li, Yubo Ma, Qi Yang...
https://pubmed.ncbi.nlm.nih.gov/28723796Bates-Jensen wound assessment tool: pictorial guide validation project.
Connie Harris, Barbara Bates-Jensen, Nancy Parslow...
https://pubmed.ncbi.nlm.nih.gov/20386331