Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
ID07346560

Primary Versus Secondary Internal Limiting Membrane Peeling in Uncomplicated Retinal Detachment

Led by Sohag University · Updated on 2026-01-16

100

Participants Needed

1

Research Sites

12 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This trial studies patients with uncomplicated rhegmatogenous retinal detachment to compare two different timings of internal limiting membrane (ILM) peeling during eye surgery. The research aims to understand whether peeling the ILM during the first surgery or delaying it until the time of silicon oil removal affects outcomes. The study is randomized and triple-masked, led by Sohag University. Participants will receive 23-gauge pars plana vitrectomy (PPV) with silicon oil tamponade. They will be randomly assigned to one of two groups: Group A will have ILM peeling performed during the initial surgery, while Group B will have ILM peeling delayed until the silicon oil is removed. Both groups receive the same PPV and silicon oil treatment. During the study, patients will be followed from enrollment until three months after surgery to monitor for complications. The main outcome measured is the incidence of complications within this period. Participants will undergo regular postoperative evaluations to assess safety and treatment effects throughout the follow-up time. Total participation duration covers from surgery through three months post-operation.

CONDITIONS

Brief Title

1ry Versus 2ry ILM Peeling in RD

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients with uncomplicated rhegmatogenous retinal detcahment
  • Age 18 years or older
Not Eligible

You will not qualify if you...

  • Proliferative vitreoretinopathy (PVR)
  • Recurrent retinal detachment
  • Tractional retinal detachment
  • Macular hole retinal detachment
  • Scleral buckling is indicated
  • Macular scarring
  • Previous pars plana vitrectomy (PPV)

AI-Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Surgery and Immediate Post-operative Care

Duration - Up to 3 months post-surgery

Participants undergo pars plana vitrectomy (PPV) with either primary internal limiting membrane (ILM) peeling or delayed ILM peeling at the time of silicon oil extraction.

Approximately 3 postoperative visits

Trial Site Locations

Total: 1 location

1

Sohag Faculty of Medicine

Sohag, Sohag Governorate, Egypt, 82511

Actively Recruiting

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Research Team

A

Alaa Sinjab, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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