Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologous Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)

What this Trial Is About

This research aims to compare two surgical techniques for repairing idiopathic full-thickness macular holes, which cause central vision loss due to a defect in the retina. The study evaluates functional vision outcomes, anatomical closure rates, and changes in macular blood flow measured by advanced imaging methods called OCT and OCTA. It focuses on large macular holes, which are more common with age and often affect females, and addresses the need to find better repair methods for challenging cases. Participants will undergo one of two treatments: surgical repair using either a Tenon capsule graft or an internal limiting membrane (ILM) flap. Both procedures involve vitrectomy performed with a specialized small-gauge system and use of a gas tamponade to support healing. The Tenon capsule graft uses biological tissue rich in cells that may aid repair, while the ILM flap technique involves repositioning retinal tissue to promote closure. Multiple surgeons will perform these operations, and patients will be divided randomly into these two groups. Participants will have thorough eye exams before surgery and then follow-up visits one day and three months after the procedure. These visits include vision tests, eye pressure measurements, and detailed imaging of the retina and its blood vessels using OCT and OCTA. Researchers will analyze visual acuity improvement and detailed retinal healing patterns as their main outcomes. The total follow-up period spans three months, during which safety and healing progress are closely monitored.

Comparison Between Outcomes of Closure of Idiopathic Macular Hole Using Autologus Tenon Capsule Graft and Internal Limiting Membrane Flap Techniques (Pilot Study)