Vitamin D Levels and Their Effects on Bone Health and Physical Function in Adults with Neurological Disorders

What this Trial Is About

The NeuroVitD study focuses on adults with neurological disorders causing motor disabilities, such as stroke, spinal cord injury, and traumatic brain injury. Researchers aim to assess vitamin D insufficiency in these populations and evaluate the effects of vitamin D supplementation on structural and functional health parameters. The study will provide important epidemiological data to help develop vitamin D guidelines for neurological conditions, addressing a current lack of data in this area. Participants will receive one of two vitamin D supplementation plans either 50,000 I.U. weekly for 8 weeks or 25,000 I.U. weekly for 4 weeks followed by 10,000 I.U. drops weekly for an additional 4 weeks. A control group with sufficient vitamin D levels will not receive supplementation. Alongside vitamin D levels, the study will measure bone density, body composition, strength, walking speed, physical performance, pain, and biochemical markers such as calcium, parathyroid hormone, and phosphorus. Participants will be inpatients undergoing usual rehabilitation care and will be evaluated at the start and end of the study period of up to two years. Researchers will collect comprehensive data including demographic, lifestyle, and biochemical assessments, using tools like DXA scans, hand dynamometers, walking tests, and pain scales. The primary outcome is the number of participants with low vitamin D levels. Secondary outcomes include improvements in structural and functional parameters with supplementation. Safety and tolerance of vitamin D will also be monitored throughout the study.

25(OH)-Vitamin D and Its Association With Structural and Functional Parameters in Hospitalized Patients With Neurological Diseases