Vitamin D Homeostasis in Sarcoidosis Evaluating Vitamin D Supplementation Effects on Sarcoidosis Severity

What this Trial Is About

Researchers are studying sarcoidosis, a disease causing inflammation in multiple organs, to understand how vitamin D levels affect the severity of this condition. The research aims to explore if restoring vitamin D in patients with low levels can reduce inflammation and improve symptoms. This Phase 4 trial also examines the unique way sarcoidosis affects vitamin D metabolism and immune response. Participants with low vitamin D will be randomly assigned to receive either vitamin D2 (ergocalciferol) supplements or placebo capsules, both given orally once a week for 12 weeks, then once a month for another 12 weeks. All participants will take daily calcium citrate with vitamin D2 tablets for 24 weeks. Those with normal vitamin D levels will be monitored as controls. The study uses a triple-blind design to reduce bias. During the 24-week study, participants will undergo lung function tests and complete questionnaires at baseline, 12 weeks, and 24 weeks. Researchers will also monitor walking ability, blood tests, metabolic profiles, vitamin D and inflammation markers, and imaging scans including PET/CT. Bone density will be checked at the start and end. These assessments will help measure changes and safety throughout the trial, which concludes with a final evaluation of lung function.

Vitamin D Homeostasis in Sarcoidosis