Status:
COMPLETED
Penicillin Prophylaxis in Sickle Cell Disease (PROPS)
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Anemia, Sickle Cell
Hematologic Diseases
Eligibility:
All Genders
Up to 5 years
Phase:
PHASE3
Brief Summary
To determine whether the regular daily administration of oral penicillin would reduce the incidence of documented infection due to Streptococcus pneumoniae in children with sickle cell anemia.
Detailed Description
BACKGROUND: For over 20 years children with sickle cell anemia have been known to have an increased susceptibility to severe bacterial infection, particularly due to Streptococcus pneumoniae. Meningi...
Eligibility Criteria
In the Phase I trial, Black children with sickle cell anemia aged 3 months to 3 years. In the Phase II trial, children with sickle cell anemia aged five years 3 months of age and younger who had received prophylactic penicillin for at least two yea
Key Trial Info
Start Date :
August 1 1983
Trial Type :
INTERVENTIONAL
End Date :
October 1 1994
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00000585
Start Date
August 1 1983
End Date
October 1 1994
Last Update
March 25 2016
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