Actively Recruiting

Age: 18Years +
All Genders
ID04615065

Acutelines: a Large Biobank Aiming to Improve Early Recognition of Acute Diseases, Contribute to the Development of Personalized Medicine and Optimize Short- and Long-term Outcome

Led by University Medical Center Groningen · Updated on 2024-06-13

35000

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are conducting a study called Acutelines, a large data and biobank project at the University Medical Center Groningen in the Netherlands. It focuses on patients with a wide range of acute medical conditions who present to the Emergency Department. The goal is to improve how acute diseases are recognized and treated, understand their outcomes, and support personalized medicine by collecting detailed clinical data, imaging, and biomaterials over time. Participants have their medical information, including demographics, health status, medical history, vital signs, diagnostic tests, and treatments, systematically collected. Biomaterials such as blood, urine, feces, and hair are gathered from patients who meet certain severity criteria. Data collection occurs during hospital admission, including continuous monitoring, and continues with follow-ups at 3 months, 1 year, 2 years, and 5 years after the initial emergency visit. Throughout the study, various assessments are performed, such as quality of life, physical functioning, mental health, symptoms, and hospital length of stay. Researchers collect data on mortality and other health outcomes for up to 50 years. The study uses digital tools to automate data capture and integrates information from multiple healthcare sources. Participants will be monitored closely during hospitalization and at scheduled intervals afterward to help improve understanding and treatment of acute diseases.

CONDITIONS

Brief Title

Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults aged 18 years or older
  • Triaged as one of the highest two categories (red or orange) by the Manchester triage system
  • Or triaged as the third highest category (yellow) and arrived by Helicopter Emergency Medical Service (HEMS)
  • Experiencing shock
  • Suspected sepsis based on clinical criteria
  • Acute kidney injury
  • Anaphylactic reaction
  • Syncope
  • Intoxication
  • Thrombosis
  • Pulmonary embolism
  • Bleeding while using anti-coagulant drugs
  • Gastro-intestinal bleeding
  • Electrolyte disturbance
Not Eligible

You will not qualify if you...

  • Referred for organ transplantation as recipient
  • Transferred from another hospital
  • Accidental contact patient material such as internal work-related accidents

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - During hospital admission

Participants presenting to the Emergency Department have clinical data, imaging data, and biomaterials collected to evaluate their acute condition.

Initial ED visit and assessments during hospitalization

Monitoring

Duration - Up to 72 hours

Participants are monitored through collection of clinical data, vital parameters, and biomaterials during the first 72 hours of hospitalization.

Continuous monitoring during hospital stay

Long-term Monitoring

Duration - Up to 5 years

Participants are followed up to collect outcome data related to health, functioning, and quality of life after their ED visit.

Follow-up visits or assessments at 3 months, 1 year, 2 years, and 5 years after ED visit

Trial Site Locations

Total: 1 location

1

University Medical Center Groningen

Groningen, Netherlands, 9700 RB

Actively Recruiting

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Research Team

H

Hjalmar Bouma, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

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Published Research Related To This Trial

Validation of plasma microRNAs as biomarkers in sepsis associated acute kidney injury upon first clinical presentation reveals limited diagnostic and prognostic performance.

Tamar J van der Aart, Matthijs Luxen, Jacqueline Koeze...

https://pubmed.ncbi.nlm.nih.gov/40906653