Status:

TERMINATED

Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia

Lead Sponsor:

National Institute of Mental Health (NIMH)

Conditions:

Psychosis

Schizophrenia

Eligibility:

All Genders

6+ years

Brief Summary

A study of children and adolescents (current N=100) with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological, early neurodev...

Detailed Description

A study of children and adolescents with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia is examining the clinical, neurobiological, early neurodevelopmental, genetic, and clinical...

Eligibility Criteria

  • INCLUSION CRITERIA:

    i. For Healthy Controls

  • Age 6 and above

  • Evidence of normal developmental history and normal functioning

ii. For Relatives of Probands

  • Ages 6 and above
  • Evidence of blood relationship to proband with a disorder under study, with usual selection of first-degree relatives, and occasional participation of more distantly-related relatives (e.g., grandparents, aunts/uncles, cousins).

EXCLUSION CRITERIA :

i.For Healthy Controls

  • Evidence of medical or neurological disease
  • Diagnosis of schizophrenia or schizoaffective disorder or in first-degree relatives by history, clinical interview, or by structured, diagnostic psychiatric interview (Diagnostic Interview for Children and Adolescents -IV)

ii.For Relatives of Probands

  • Absence of consent on the part of the proband or parent(s) of proband to contact relatives
  • Absence of signed consent or assent by relative(s) to participate
  • Lack of consent capacity

Key Trial Info

Start Date :

March 19 1984

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

October 10 2017

Estimated Enrollment :

1556 Patients enrolled

Trial Details

Trial ID

NCT00001198

Start Date

March 19 1984

End Date

October 10 2017

Last Update

October 12 2017

Active Locations (1)

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1

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, United States, 20892