Status:
TERMINATED
Evaluating Genetic Risk Factors for Childhood-Onset Schizophrenia
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Psychosis
Schizophrenia
Eligibility:
All Genders
6+ years
Brief Summary
A study of children and adolescents (current N=100) with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia with (97-M-0126) is examining the clinical, neurobiological, early neurodev...
Detailed Description
A study of children and adolescents with very early onset by age 12 (COS) of DSM-III-R defined schizophrenia is examining the clinical, neurobiological, early neurodevelopmental, genetic, and clinical...
Eligibility Criteria
-
INCLUSION CRITERIA:
i. For Healthy Controls
-
Age 6 and above
-
Evidence of normal developmental history and normal functioning
ii. For Relatives of Probands
- Ages 6 and above
- Evidence of blood relationship to proband with a disorder under study, with usual selection of first-degree relatives, and occasional participation of more distantly-related relatives (e.g., grandparents, aunts/uncles, cousins).
EXCLUSION CRITERIA :
i.For Healthy Controls
- Evidence of medical or neurological disease
- Diagnosis of schizophrenia or schizoaffective disorder or in first-degree relatives by history, clinical interview, or by structured, diagnostic psychiatric interview (Diagnostic Interview for Children and Adolescents -IV)
ii.For Relatives of Probands
- Absence of consent on the part of the proband or parent(s) of proband to contact relatives
- Absence of signed consent or assent by relative(s) to participate
- Lack of consent capacity
Key Trial Info
Start Date :
March 19 1984
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 10 2017
Estimated Enrollment :
1556 Patients enrolled
Trial Details
Trial ID
NCT00001198
Start Date
March 19 1984
End Date
October 10 2017
Last Update
October 12 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892