Plasma metanephrines in the diagnosis of pheochromocytoma.
F Elijovich
https://pubmed.ncbi.nlm.nih.gov/8607605Completed
All Genders
Healthy Volunteers
ID00001229
Diagnosis and Treatment of Pheochromocytoma
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2008-03-04
240
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Pheochromocytoma is a tumor of the adrenal gland. This tumor is typically benign (not cancerous) and can be cured by surgical removal. However, pheochromocytomas produce neurohormones called cateholamines (epinephrine and norepinephrine). High levels of catecholamines can result in high blood pressure, headaches, sweating, heart palpitations, nausea, vomiting, and other symptoms. These tumors are considered dangerous because of their unpredictable behavior. Patients with pheochromocytoma may experience blood pressures high enough to cause a stroke or heart attack in patients. This study is designed to take patients suspected of having pheochromocytoma and confirm the diagnosis. This will be done using a variety of laboratory tests including a clonidine suppression test and glucagon stimulation test. These tests use drugs that can stimulate or reduce the activity of the tumor if it is present in the body. Once a diagnosis is confirmed, patients participating in this study will undergo standard procedures to find the exact location of the tumor and receive standard therapy for the condition.
CONDITIONS
Official Title
Diagnosis and Treatment of Pheochromocytoma
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
Patients of any age and either sex who are suspected of having a pheochromocytoma on the basis of one or more of the following: 1. hypertensive episodes in a normotensive subject, 2. abnormal levels of blood and/or urinary catecholamines or their metabolites, or 3. an otherwise unexplained abdominal mass.
Patients without any evidence of pheochromocytoma are excluded.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Heart, Lung and Blood Institute (NHLBI)
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Glucagon and clonidine testing in the diagnosis of pheochromocytoma.
E Grossman, D S Goldstein, A Hoffman...
https://pubmed.ncbi.nlm.nih.gov/2045133A critical review of diagnostic tests for pheochromocytoma.
A Amery, J Conway
https://pubmed.ncbi.nlm.nih.gov/5333928