Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition.
Andreas Meyer-Lindenberg, Richard E Straub, Barbara K Lipska...
https://pubmed.ncbi.nlm.nih.gov/17290303Terminated
All Genders
Healthy Volunteers
ID00001260
Brain Procurement for the Human Brain Collection Core
Led by National Institute of Mental Health (NIMH) · Updated on 2019-12-09
2161
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Information gained from donated tissue may lead to better treatments and potential cures for nervous system and mental disorders. This study will ask relatives of deceased individuals to donate the brains of their deceased relatives to allow further study of neurological and psychiatric disorders. We do not accept prospective donations.
CONDITIONS
Official Title
Brain Tissue Collection for Neuropathological Studies
Who Can Participate
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- INCLUSION CRITERIA:
Brain tissue is needed from individuals suffering from a variety of neuropsychiatric disorders, especially schizophrenia, but also anxiety disorders, suicide, bipolar disorder, depression, Tourette's Syndrome, drug addictions (PCP, cocaine, alcohol, heroin or the like) and any form of dementia. In addition, brains from normal individuals without a history of neuropsychiatric disease will be needed for controls.
EXCLUSION CRITERIA:
No living subjects are enrolled in this protocol. Tissue is obtained after death, with the permission of next of kin, or from existing institutions with appropriate samples via an MTA or other applicable agreement.
Brain tissue is excluded from collection if there is a previously known history of strokes, lesions, or other major neuropathological abnormalities prior to the consenting process.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 3 locations
1
Office of the Chief Medical Examiner
Washington D.C., District of Columbia, United States, 20003
Status Unknown
2
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Status Unknown
3
Office of the Chief Medical Examiner
Fairfax, Virginia, United States, 22032
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
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Amanda J Law, Barbara K Lipska, Cynthia Shannon Weickert...
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Michael F Egan, Richard E Straub, Terry E Goldberg...
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Elijah F W Bowen, Jack L Burgess, Richard Granger...
https://pubmed.ncbi.nlm.nih.gov/31073119The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders.
Rodrigo B Mansur, Gabriel R Fries, Alisson P Trevizol...
https://pubmed.ncbi.nlm.nih.gov/30409537Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes.
Rodrigo B Mansur, Gabriel R Fries, Mehala Subramaniapillai...
https://pubmed.ncbi.nlm.nih.gov/30391805The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders.
X Xiao, C Zhang, M Grigoroiu-Serbanescu...
https://pubmed.ncbi.nlm.nih.gov/29158582