Completed
Open Label Positron Emission Tomography Study With [18F]AZD4694 and [11C]AZD2184, Candidate Radioligands for AB Amyloid, to Determine and Compare in Vivo Brain Uptake and Distribution in Healthy Volunteers and Patients With Alzheimer's Disease
Led by AstraZeneca · Updated on 2009-10-23
26
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is carried out in order to investigate if \[18F\]AZD4694, compared to \[11C\]AZD2184, is a suitable PET ligand for in vivo imaging of Aβ amyloid depositions in the human brain. In the study the two PET ligands will be examined in both healthy volunteers and patients with Alzheimer's Disease. A whole body dosimetry scanning will be performed in 6 healthy volunteers to obtain human data to estimate a safe dose.
CONDITIONS
Official Title
Positron Emission Tomography (PET) Study With [18F]AZD4694 and [11C]AZD2184, Candidate PET Ligands for Aβ Amyloid
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Alzheimer's Disease patients - 50-85 years, mild to moderate AD: MMSE ≥16 and ≤ 26, clinical progression of AD over 12 months.
- Healthy volunteers: - 50-75 years
- BMI 18 and 30 m2/kg
- Clinically normal physical findings including supine blood pressure and pulse rate.
You will not qualify if you...
- Alzheimer's Disease patients - Clinically significant illness the 2 weeks prior to the administration of the PET ligand
- Significant cerebrovascular disease or depression, central nervous system infarct or infection or lesions
- Administration of any investigational product within 3 months prior to study and/or PET measurements for scientific purposes within the last 12 months.
- Healthy volunteers - clinically significant illness within 2 weeks before administration of PET ligand, history of psychiatric or somatic disease/condition that may interfere, first degree relative with dementia. Obvious deterioration of memory functions.
Trial Site Locations
Total: 2 locations
1
Research Site
Huddinge, Sweden
Status Unknown
2
Research Site
Stockholm, Sweden
Status Unknown
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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